Protein interactions for ERGIC3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ERGIC3
Gene descriptionⁱ Full gene name according to HGNC.	ERGIC and golgi 3
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Glycosylation (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.20
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Not available
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

Highlight:

Off

Subcell location

Predicted location

Tissue specificity

Protein class

Filter menu »

e.g. Brain enriched, Localized to mitochondria, Non-specific - Glycosylation

Field

Cluster

Pathway

Number of interactions:

186

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
MARCHF2	Physical association	High	0.71	23
ERGIC1	Physical association	High	0.62	4
ABHD16A	Physical association	Medium	0.56	46
AGPAT4	Physical association	Medium	0.56	22
ALG10	Physical association	Medium	0.56	5
AOC2	Physical association	Medium	0.56	2
APOC3	Physical association	Medium	0.56	3
APOD	Physical association	Medium	0.56	38
APOL2	Physical association	Medium	0.56	26
AQP10	Physical association	Medium	0.56	17
AQP2	Physical association	Medium	0.56	33
AQP3	Physical association	Medium	0.56	23
ASGR1	Physical association	Medium	0.56	27
ATP6V0C	Physical association	Medium	0.56	47
BCL2L1	Physical association	Medium	0.56	22
BCL2L2	Physical association	Medium	0.56	45
BCL2L2-PABPN1	Physical association	Medium	0.56	45
BET1	Physical association	Medium	0.56	41
BIK	Physical association	Medium	0.56	79
BNIP3	Physical association	Medium	0.56	49
BTN2A2	Physical association	Medium	0.56	33
C14orf180	Physical association	Medium	0.56	38
C2	Physical association	Medium	0.56	6
C2CD2L	Physical association	Medium	0.56	31
C3orf52	Physical association	Medium	0.56	57
CCDC167	Physical association	Medium	0.56	32
CD207	Physical association	Medium	0.56	5
CD302	Physical association	Medium	0.56	9
CD81	Physical association	Medium	0.56	22
CDIPT	Physical association	Medium	0.56	47
CDS2	Physical association	Medium	0.56	29
CFHR5	Physical association	Medium	0.56	15
CIAO2A	Physical association	Medium	0.56	21
CLDN8	Physical association	Medium	0.56	8
CLDND2	Physical association	Medium	0.56	24
CNIH1	Physical association	Medium	0.56	21
CNIH3	Physical association	Medium	0.56	23
COX20	Physical association	Medium	0.56	19
CTXN3	Physical association	Medium	0.56	51
CXorf66	Physical association	Medium	0.56	8
CYB561	Physical association	Medium	0.56	49
CYB561D2	Physical association	Medium	0.56	16
CYBC1	Physical association	Medium	0.56	51
CYP4F2	Physical association	Medium	0.56	33
DEFB103A	Physical association	Medium	0.56	9
DEFB103B	Physical association	Medium	0.56	9
EBP	Physical association	Medium	0.56	159
EHHADH	Physical association	Medium	0.56	94
EMC6	Physical association	Medium	0.56	16
EMP1	Physical association	Medium	0.56	55
EMP3	Physical association	Medium	0.56	45
EXTL1	Physical association	Medium	0.56	4
FA2H	Physical association	Medium	0.56	25
FAM3C	Physical association	Medium	0.56	45
FAXDC2	Physical association	Medium	0.56	28
FETUB	Physical association	Medium	0.56	6
FIS1	Physical association	Medium	0.56	22
FKBP8	Physical association	Medium	0.56	32
FXYD6	Physical association	Medium	0.56	44
GAST	Physical association	Medium	0.56	18
GIMAP1	Physical association	Medium	0.56	40
GIMAP5	Physical association	Medium	0.56	53
GJB2	Physical association	Medium	0.56	33
GPR151	Physical association	Medium	0.56	35
GYPA	Physical association	Medium	0.56	24
HHATL	Physical association	Medium	0.56	13
HMOX1	Physical association	Medium	0.56	25
HMOX2	Physical association	Medium	0.56	44
IFITM3	Physical association	Medium	0.56	22
IGFBP5	Physical association	Medium	0.56	63
ITGAM	Physical association	Medium	0.56	34
JAGN1	Physical association	Medium	0.56	102
KCNK1	Physical association	Medium	0.56	8
LHFPL5	Physical association	Medium	0.56	108
LPAR3	Physical association	Medium	0.56	46
LPCAT2	Physical association	Medium	0.56	7
MARCHF5	Physical association	Medium	0.56	25
MFSD6	Physical association	Medium	0.56	31
MIP	Physical association	Medium	0.56	35
MS4A13	Physical association	Medium	0.56	52
MYADM	Physical association	Medium	0.56	9
MYG1	Physical association	Medium	0.56	35
NDUFB6	Physical association	Medium	0.56	1
NEU1	Physical association	Medium	0.56	16
NINJ2	Physical association	Medium	0.56	63
NKG7	Physical association	Medium	0.56	39
NRG4	Physical association	Medium	0.56	4
NRM	Physical association	Medium	0.56	50
NSG1	Physical association	Medium	0.56	25
ORMDL1	Physical association	Medium	0.56	31
ORMDL3	Physical association	Medium	0.56	23
PAQR5	Physical association	Medium	0.56	5
PAQR7	Physical association	Medium	0.56	4
PEX11G	Physical association	Medium	0.56	5
PEX16	Physical association	Medium	0.56	23
PLLP	Physical association	Medium	0.56	33
PLPP4	Physical association	Medium	0.56	29
PMP22	Physical association	Medium	0.56	52
POMGNT1	Physical association	Medium	0.56	6
RFT1	Physical association	Medium	0.56	9
RHAG	Physical association	Medium	0.56	4
RTP2	Physical association	Medium	0.56	63
RUSF1	Physical association	Medium	0.56	49
SCARB2	Physical association	Medium	0.56	5
SCD	Physical association	Medium	0.56	36
SEC22B	Physical association	Medium	0.56	45
SEC23A	Physical association	Medium	0.56	23
SELENOK	Physical association	Medium	0.56	24
SERP2	Physical association	Medium	0.56	42
SFXN5	Physical association	Medium	0.56	8
SLC13A3	Physical association	Medium	0.56	9
SLC1A1	Physical association	Medium	0.56	8
SLC30A8	Physical association	Medium	0.56	66
SLC35A1	Physical association	Medium	0.56	27
SLC35A4	Physical association	Medium	0.56	23
SLC35B2	Physical association	Medium	0.56	9
SLC35B4	Physical association	Medium	0.56	25
SLC38A7	Physical association	Medium	0.56	43
SLC41A1	Physical association	Medium	0.56	26
SLC41A2	Physical association	Medium	0.56	28
SMAGP	Physical association	Medium	0.56	35
SMCO4	Physical association	Medium	0.56	51
SMIM1	Physical association	Medium	0.56	48
SMIM3	Physical association	Medium	0.56	44
SNORC	Physical association	Medium	0.56	20
SPN	Physical association	Medium	0.56	6
STATH	Physical association	Medium	0.56	21
STX12	Physical association	Medium	0.56	33
STX1B	Physical association	Medium	0.56	21
STX3	Physical association	Medium	0.56	33
STX8	Physical association	Medium	0.56	58
SYNJ2BP	Physical association	Medium	0.56	22
SYS1	Physical association	Medium	0.56	14
TAP1	Physical association	Medium	0.56	17
TECR	Physical association	Medium	0.56	22
TF	Physical association	Medium	0.56	20
THBD	Physical association	Medium	0.56	19
TM4SF4	Physical association	Medium	0.56	19
TMEM100	Physical association	Medium	0.56	32
TMEM107	Physical association	Medium	0.56	38
TMEM109	Physical association	Medium	0.56	13
TMEM120B	Physical association	Medium	0.56	46
TMEM141	Physical association	Medium	0.56	3
TMEM14A	Physical association	Medium	0.56	21
TMEM14B	Physical association	Medium	0.56	193
TMEM179B	Physical association	Medium	0.56	45
TMEM203	Physical association	Medium	0.56	34
TMEM218	Physical association	Medium	0.56	61
TMEM222	Physical association	Medium	0.56	30
TMEM229B	Physical association	Medium	0.56	34
TMEM243	Physical association	Medium	0.56	37
TMEM42	Physical association	Medium	0.56	41
TMEM60	Physical association	Medium	0.56	86
TMEM65	Physical association	Medium	0.56	29
TMEM86A	Physical association	Medium	0.56	38
TMEM86B	Physical association	Medium	0.56	92
TMEM97	Physical association	Medium	0.56	49
TMUB2	Physical association	Medium	0.56	15
TNFRSF10C	Physical association	Medium	0.56	23
TOMM6	Physical association	Medium	0.56	9
TRAM1L1	Physical association	Medium	0.56	20
TRIM32	Physical association	Medium	0.56	30
TSPAN33	Physical association	Medium	0.56	23
TSPO2	Physical association	Medium	0.56	49
UBE2J1	Physical association	Medium	0.56	34
UBIAD1	Physical association	Medium	0.56	33
UNC50	Physical association	Medium	0.56	29
UNC93B1	Physical association	Medium	0.56	24
VAMP2	Physical association	Medium	0.56	25
VAMP3	Physical association	Medium	0.56	46
VAMP4	Physical association	Medium	0.56	35
VAMP5	Physical association	Medium	0.56	58
VKORC1	Physical association	Medium	0.56	12
VKORC1L1	Physical association	Medium	0.56	15
VMP1	Physical association	Medium	0.56	6
VTI1B	Physical association	Medium	0.56	26
YIF1A	Physical association	Medium	0.56	66
YIPF1	Physical association	Medium	0.56	30
YIPF2	Physical association	Medium	0.56	19
YIPF4	Physical association	Medium	0.56	28
YIPF6	Physical association	Medium	0.56	72
ZDHHC15	Physical association	Medium	0.56	47
ZDHHC21	Physical association	Medium	0.56	10
ZFPL1	Physical association	Medium	0.56	54
HP	Physical association	Medium	0.52	3
SERPINA1	Physical association	Medium	0.52	4
Show allShow less

METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
ERGIC3 is not a metabolic protein