Protein interactions for EHHADH - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EHHADH
Gene descriptionⁱ Full gene name according to HGNC.	Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Liver & Kidney - Metabolism (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Group enriched (kidney, liver)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.69
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Not available
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

Highlight:

Off

Subcell location

Predicted location

Tissue specificity

Protein class

Filter menu »

e.g. Brain enriched, Localized to mitochondria, Liver & Kidney - Metabolism

Field

Cluster

Pathway

Number of interactions:

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
MID1	Physical association	High	0.78	27
TRIM41	Physical association	High	0.78	108
DES	Physical association	High	0.72	36
TRIM27	Physical association	High	0.72	232
ZBTB9	Physical association	High	0.72	28
ACTB	Physical association	High	0.67	25
ACTG1	Physical association	High	0.67	14
CBS	Physical association	High	0.67	17
CCDC102B	Physical association	High	0.67	87
FUNDC1	Physical association	High	0.67	13
KCTD6	Physical association	High	0.67	20
KCTD9	Physical association	High	0.67	77
SSNA1	Physical association	High	0.67	12
TNIP1	Physical association	High	0.67	67
TPP2	Physical association	High	0.67	3
AARS2	Physical association	Medium	0.56	1
ARMCX3	Physical association	Medium	0.56	3
BHLHE40	Physical association	Medium	0.56	52
C1orf50	Physical association	Medium	0.56	11
CCDC13	Physical association	Medium	0.56	37
CDR2L	Physical association	Medium	0.56	49
CFL2	Physical association	Medium	0.56	10
CISD2	Physical association	Medium	0.56	58
CLDN18	Physical association	Medium	0.56	2
CLDN5	Physical association	Medium	0.56	33
CLK2	Physical association	Medium	0.56	45
CMTM6	Physical association	Medium	0.56	17
COQ9	Physical association	Medium	0.56	32
CYB561	Physical association	Medium	0.56	49
CYB561A3	Physical association	Medium	0.56	21
DERL3	Physical association	Medium	0.56	14
DIABLO	Physical association	Medium	0.56	25
EBP	Physical association	Medium	0.56	159
EMP1	Physical association	Medium	0.56	55
ERGIC1	Physical association	Medium	0.56	4
ERGIC3	Physical association	Medium	0.56	186
ERVFRD-1	Physical association	Medium	0.56	21
GAS8	Physical association	Medium	0.56	97
GMCL1	Physical association	Medium	0.56	50
GRIPAP1	Physical association	Medium	0.56	46
HID1	Physical association	Medium	0.56	9
HIP1	Physical association	Medium	0.56	48
HMG20A	Physical association	Medium	0.56	52
HSD17B11	Physical association	Medium	0.56	54
IKZF3	Physical association	Medium	0.56	130
JAGN1	Physical association	Medium	0.56	102
KRTAP10-7	Physical association	Medium	0.56	239
KRTAP4-11	Physical association	Medium	0.56	61
LCN2	Physical association	Medium	0.56	47
LEPROTL1	Physical association	Medium	0.56	68
LTBR	Physical association	Medium	0.56	5
LYPD5	Physical association	Medium	0.56	8
LZTFL1	Physical association	Medium	0.56	15
LZTS2	Physical association	Medium	0.56	178
MAB21L3	Physical association	Medium	0.56	24
NACC1	Physical association	Medium	0.56	10
ORMDL1	Physical association	Medium	0.56	31
PAQR8	Physical association	Medium	0.56	3
PICK1	Physical association	Medium	0.56	275
PNMA1	Physical association	Medium	0.56	114
PNMA5	Physical association	Medium	0.56	53
PPP1R12C	Physical association	Medium	0.56	14
PRKRA	Physical association	Medium	0.56	13
PRMT5	Physical association	Medium	0.56	51
PSTPIP1	Physical association	Medium	0.56	42
PTGES	Physical association	Medium	0.56	15
RNF4	Physical association	Medium	0.56	80
RPRM	Physical association	Medium	0.56	66
RUSF1	Physical association	Medium	0.56	49
SDR16C5	Physical association	Medium	0.56	9
SFT2D1	Physical association	Medium	0.56	27
SGCB	Physical association	Medium	0.56	10
SLC14A2	Physical association	Medium	0.56	9
SLC39A2	Physical association	Medium	0.56	45
SMIM5	Physical association	Medium	0.56	7
SMN1	Physical association	Medium	0.56	65
SMN2	Physical association	Medium	0.56	65
SSMEM1	Physical association	Medium	0.56	88
SSX2IP	Physical association	Medium	0.56	78
SYNGR3	Physical association	Medium	0.56	15
TMEM121	Physical association	Medium	0.56	12
TMEM17	Physical association	Medium	0.56	4
TMEM35A	Physical association	Medium	0.56	22
TRAF1	Physical association	Medium	0.56	166
TRAF2	Physical association	Medium	0.56	237
TRIM21	Physical association	Medium	0.56	24
TRIM23	Physical association	Medium	0.56	142
TRIM54	Physical association	Medium	0.56	151
TRIM63	Physical association	Medium	0.56	10
VAC14	Physical association	Medium	0.56	83
ZBTB26	Physical association	Medium	0.56	27
ZBTB8A	Physical association	Medium	0.56	58
ZCCHC17	Physical association	Medium	0.56	13
ZRANB1	Physical association	Medium	0.56	112
Show allShow less

METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene EHHADH is associated with 227 reactions in 24 different subsystems, and present in the compartments: Cytosol, Mitochondria, Nucleus, Peroxisome. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Fatty acid oxidation	Cytosol, Endoplasmic reticulum, Peroxisome, Mitochondria, Extracellular	69	373	78
Beta oxidation of phytanic acid (peroxisomal)	Peroxisome, Cytosol	23	37	6
Beta oxidation of odd-chain fatty acids (mitochondrial)	Mitochondria	12	47	9
Beta oxidation of even-chain fatty acids (mitochondrial)	Mitochondria	13	68	9
Omega-6 fatty acid metabolism	Cytosol, Mitochondria, Peroxisome	39	56	11
Beta oxidation of branched-chain fatty acids (mitochondrial)	Mitochondria	10	23	3
Beta oxidation of unsaturated fatty acids (n-9) (peroxisomal)	Peroxisome	9	47	20
Drug metabolism	Cytosol, Mitochondria, Peroxisome, Extracellular, Endoplasmic reticulum	55	210	3
Beta oxidation of di-unsaturated fatty acids (n-6) (mitochondrial)	Mitochondria	16	28	5
Beta oxidation of di-unsaturated fatty acids (n-6) (peroxisomal)	Peroxisome	11	28	10
Omega-3 fatty acid metabolism	Cytosol, Peroxisome, Nucleus, Endoplasmic reticulum	53	73	2
Beta oxidation of even-chain fatty acids (peroxisomal)	Peroxisome	9	59	24
Beta oxidation of unsaturated fatty acids (n-7) (mitochondrial)	Mitochondria	14	26	4
Beta oxidation of poly-unsaturated fatty acids (mitochondrial)	Mitochondria	11	34	4
Transport reactions	Cytosol, Extracellular, Lysosome, Peroxisome, Mitochondria, Golgi apparatus, Endoplasmic reticulum, Nucleus, Inner mitochondria	587	1603	1
Leukotriene metabolism	Peroxisome, Mitochondria, Cytosol, Endoplasmic reticulum, Nucleus, Extracellular	205	105	17
Bile acid biosynthesis	Peroxisome, Endoplasmic reticulum, Cytosol, Mitochondria, Extracellular	93	173	4
Beta-alanine metabolism	Cytosol, Mitochondria, Peroxisome	21	32	2
Valine, leucine, and isoleucine metabolism	Mitochondria, Cytosol, Peroxisome	73	71	2
Steroid metabolism	Mitochondria, Cytosol, Endoplasmic reticulum, Golgi apparatus, Lysosome	95	97	1
Beta oxidation of unsaturated fatty acids (n-7) (peroxisomal)	Peroxisome	9	17	4
Beta oxidation of unsaturated fatty acids (n-9) (mitochondrial)	Mitochondria	14	30	5
Isolated	Cytosol, Mitochondria, Peroxisome, Endoplasmic reticulum, Nucleus, Extracellular	535	309	2
Tryptophan metabolism	Mitochondria, Cytosol	24	40	1