Protein interactions for VAC14 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	VAC14
Gene descriptionⁱ Full gene name according to HGNC.	VAC14 component of PIKFYVE complex
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Mitochondrial translation (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.15
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Vesicles In addition localized to the Cytosol
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Mitochondrial translation

Field

Cluster

Pathway

Number of interactions:

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
C4orf33	Physical association	High	0.83	4
CCDC103	Physical association	High	0.83	17
CDRT4	Physical association	High	0.78	1
COL8A1	Physical association	High	0.78	51
FIG4	Physical association	High	0.74	2
NTAQ1	Physical association	High	0.74	302
PIKFYVE	Physical association	High	0.74	1
ACSS1	Physical association	High	0.72	1
BHLHE40	Physical association	High	0.72	52
GINS3	Physical association	High	0.72	8
KRTAP19-5	Physical association	High	0.72	82
KRTAP19-7	Physical association	High	0.72	71
MPPED2	Physical association	High	0.72	10
NGB	Physical association	High	0.72	13
PRR13	Physical association	High	0.72	37
RHOXF2	Physical association	High	0.72	52
SIGLEC5	Physical association	High	0.72	5
TP53BP1	Physical association	High	0.72	71
ASB13	Physical association	High	0.67	10
C11orf54	Physical association	High	0.67	3
CASP1	Physical association	High	0.67	9
CD209	Physical association	High	0.67	1
KYAT1	Physical association	High	0.67	2
PHYKPL	Physical association	High	0.67	4
RBFOX2	Physical association	High	0.67	18
SMUG1	Physical association	High	0.67	5
SNF8	Physical association	High	0.67	19
SPRYD7	Physical association	High	0.67	4
ZNF34	Physical association	High	0.67	2
NBEAL2	Physical association	High	0.65	3
NOS1	Direct interaction	High	0.62	1
ARID5A	Physical association	Medium	0.56	94
ATP1A3	Physical association	Medium	0.56	15
C2CD6	Physical association	Medium	0.56	44
CRYBA1	Physical association	Medium	0.56	18
CRYBA2	Physical association	Medium	0.56	21
EEF1AKMT3	Physical association	Medium	0.56	4
EHHADH	Physical association	Medium	0.56	94
EIF2S1	Physical association	Medium	0.56	9
EIF6	Physical association	Medium	0.56	5
FAM50B	Physical association	Medium	0.56	39
GABPB2	Physical association	Medium	0.56	7
GLIS2	Physical association	Medium	0.56	27
GNB1	Physical association	Medium	0.56	7
HDHD3	Physical association	Medium	0.56	11
HNF1B	Physical association	Medium	0.56	8
HTT	Physical association	Medium	0.56	665
INTS11	Physical association	Medium	0.56	27
JMJD7	Physical association	Medium	0.56	14
KRBOX5	Physical association	Medium	0.56	1
KRT82	Physical association	Medium	0.56	11
KRTAP15-1	Physical association	Medium	0.56	53
KRTAP19-3	Physical association	Medium	0.56	11
KRTAP6-1	Physical association	Medium	0.56	70
KRTAP6-2	Physical association	Medium	0.56	136
MTMR9	Physical association	Medium	0.56	16
MYOZ1	Physical association	Medium	0.56	28
NDUFAB1	Physical association	Medium	0.56	25
OIT3	Physical association	Medium	0.56	9
OTOS	Physical association	Medium	0.56	3
PBLD	Physical association	Medium	0.56	8
PECAM1	Physical association	Medium	0.56	58
PELI1	Physical association	Medium	0.56	15
PHF1	Physical association	Medium	0.56	45
PPP2CA	Physical association	Medium	0.56	29
PPP6C	Physical association	Medium	0.56	8
PRADC1	Physical association	Medium	0.56	1
PRR20C	Physical association	Medium	0.56	20
PRR20D	Physical association	Medium	0.56	55
RHBDL1	Physical association	Medium	0.56	8
RIPPLY1	Physical association	Medium	0.56	28
RNASEH2C	Physical association	Medium	0.56	2
TCEANC	Physical association	Medium	0.56	24
TDP1	Physical association	Medium	0.56	7
TEX37	Physical association	Medium	0.56	32
UFSP1	Physical association	Medium	0.56	30
VENTX	Physical association	Medium	0.56	60
VHLL	Physical association	Medium	0.56	4
VIM	Physical association	Medium	0.56	86
WDR83	Physical association	Medium	0.56	30
WRAP53	Physical association	Medium	0.56	6
ZBTB49	Physical association	Medium	0.56	11
CRK	Physical association	Medium	0.49	54
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
VAC14 is not a metabolic protein