Protein interactions for KRTAP6-2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	KRTAP6-2
Gene descriptionⁱ Full gene name according to HGNC.	Keratin associated protein 6-2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Not detected - no cluster assigned
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Not detected
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	Not detected
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Not detected
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Not available
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria

Field

Cluster

Pathway

Number of interactions:

136

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
TEX37	Physical association	High	0.6	32
ANXA11	Physical association	Medium	0.56	8
APOBEC1	Physical association	Medium	0.56	7
AQP1	Physical association	Medium	0.56	106
ARID5A	Physical association	Medium	0.56	94
ATOSB	Physical association	Medium	0.56	50
ATPAF2	Physical association	Medium	0.56	57
BEX2	Physical association	Medium	0.56	67
BHLHE40	Physical association	Medium	0.56	52
C1orf94	Physical association	Medium	0.56	69
C20orf85	Physical association	Medium	0.56	19
C6orf15	Physical association	Medium	0.56	5
CAMK2A	Physical association	Medium	0.56	52
CASC3	Physical association	Medium	0.56	6
CATSPER1	Physical association	Medium	0.56	95
CCDC120	Physical association	Medium	0.56	90
CCER1	Physical association	Medium	0.56	10
CELF5	Physical association	Medium	0.56	19
CERCAM	Physical association	Medium	0.56	28
CERK	Physical association	Medium	0.56	19
CFP	Physical association	Medium	0.56	22
CHIC2	Physical association	Medium	0.56	53
COL8A1	Physical association	Medium	0.56	51
CTRC	Physical association	Medium	0.56	12
CYSRT1	Physical association	Medium	0.56	396
DAZAP2	Physical association	Medium	0.56	124
DHRS1	Physical association	Medium	0.56	25
DMRT3	Physical association	Medium	0.56	65
ENKD1	Physical association	Medium	0.56	159
FAM83A	Physical association	Medium	0.56	22
FOXD2	Physical association	Medium	0.56	14
FOXD4L1	Physical association	Medium	0.56	17
FOXD4L3	Physical association	Medium	0.56	14
FOXP3	Physical association	Medium	0.56	11
FRS3	Physical association	Medium	0.56	77
GALT	Physical association	Medium	0.56	6
GCM2	Physical association	Medium	0.56	22
GLIS2	Physical association	Medium	0.56	27
GLYCTK	Physical association	Medium	0.56	48
GPS2	Physical association	Medium	0.56	31
GRINA	Physical association	Medium	0.56	6
GRN	Physical association	Medium	0.56	216
GSTP1	Physical association	Medium	0.56	21
HAPLN2	Physical association	Medium	0.56	36
HEY1	Physical association	Medium	0.56	6
HEY2	Physical association	Medium	0.56	17
HEYL	Physical association	Medium	0.56	5
HHEX	Physical association	Medium	0.56	23
HOXB9	Physical association	Medium	0.56	42
HOXC8	Physical association	Medium	0.56	74
HOXC9	Physical association	Medium	0.56	14
HYAL2	Physical association	Medium	0.56	12
INCA1	Physical association	Medium	0.56	204
INO80B	Physical association	Medium	0.56	49
KLHL38	Physical association	Medium	0.56	72
KPRP	Physical association	Medium	0.56	80
KRT83	Physical association	Medium	0.56	31
KRTAP11-1	Physical association	Medium	0.56	83
KRTAP12-1	Physical association	Medium	0.56	50
KRTAP12-2	Physical association	Medium	0.56	97
KRTAP12-3	Physical association	Medium	0.56	117
KRTAP12-4	Physical association	Medium	0.56	41
KRTAP15-1	Physical association	Medium	0.56	53
KRTAP19-5	Physical association	Medium	0.56	82
KRTAP26-1	Physical association	Medium	0.56	73
KRTAP3-3	Physical association	Medium	0.56	60
KRTAP4-11	Physical association	Medium	0.56	61
KRTAP4-12	Physical association	Medium	0.56	74
KRTAP6-1	Physical association	Medium	0.56	70
LCE2B	Physical association	Medium	0.56	55
LCE2D	Physical association	Medium	0.56	51
LCE5A	Physical association	Medium	0.56	53
LETM1	Physical association	Medium	0.56	3
LGALS9C	Physical association	Medium	0.56	23
LRFN4	Physical association	Medium	0.56	8
LRRC41	Physical association	Medium	0.56	6
LYVE1	Physical association	Medium	0.56	21
MKRN3	Physical association	Medium	0.56	118
NAF1	Physical association	Medium	0.56	17
NDUFA9	Physical association	Medium	0.56	9
NFKBID	Physical association	Medium	0.56	83
NPBWR2	Physical association	Medium	0.56	15
OLIG3	Physical association	Medium	0.56	24
OTX1	Physical association	Medium	0.56	118
PATL1	Physical association	Medium	0.56	15
PDP1	Physical association	Medium	0.56	3
PITX1	Physical association	Medium	0.56	50
PKD2	Physical association	Medium	0.56	12
PLSCR4	Physical association	Medium	0.56	45
POGZ	Physical association	Medium	0.56	58
POU5F2	Physical association	Medium	0.56	1
PRR13	Physical association	Medium	0.56	37
PRR3	Physical association	Medium	0.56	21
PRR30	Physical association	Medium	0.56	3
PRR35	Physical association	Medium	0.56	57
RASD1	Physical association	Medium	0.56	23
RBPMS2	Physical association	Medium	0.56	40
RERE	Physical association	Medium	0.56	5
RHOXF2	Physical association	Medium	0.56	52
RNF38	Physical association	Medium	0.56	11
ROR2	Physical association	Medium	0.56	24
RTP5	Physical association	Medium	0.56	49
RUSC1	Physical association	Medium	0.56	71
SAMD7	Physical association	Medium	0.56	5
SIAH3	Physical association	Medium	0.56	1
SMAP2	Physical association	Medium	0.56	10
SMARCC1	Physical association	Medium	0.56	31
SMN1	Physical association	Medium	0.56	65
SMN2	Physical association	Medium	0.56	65
SNRPC	Physical association	Medium	0.56	43
TBX6	Physical association	Medium	0.56	24
TEKT3	Physical association	Medium	0.56	28
TEKT4	Physical association	Medium	0.56	80
TEKT5	Physical association	Medium	0.56	28
TENT5B	Physical association	Medium	0.56	57
TENT5D	Physical association	Medium	0.56	12
TEPSIN	Physical association	Medium	0.56	101
TFAP2D	Physical association	Medium	0.56	48
TLX2	Physical association	Medium	0.56	5
TLX3	Physical association	Medium	0.56	68
TNIP1	Physical association	Medium	0.56	67
TOLLIP	Physical association	Medium	0.56	41
TRIP13	Physical association	Medium	0.56	71
TSGA10IP	Physical association	Medium	0.56	83
TSPAN4	Physical association	Medium	0.56	30
TSPYL6	Physical association	Medium	0.56	9
VAC14	Physical association	Medium	0.56	83
VENTX	Physical association	Medium	0.56	60
VPS37C	Physical association	Medium	0.56	72
ZC3H10	Physical association	Medium	0.56	28
ZIC1	Physical association	Medium	0.56	55
ZNF414	Physical association	Medium	0.56	42
ZNF503	Physical association	Medium	0.56	8
ZNF581	Physical association	Medium	0.56	82
ZNF683	Physical association	Medium	0.56	5
ZNF843	Physical association	Medium	0.56	3
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
KRTAP6-2 is not a metabolic protein