Protein interactions for DAZAP2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DAZAP2
Gene descriptionⁱ Full gene name according to HGNC.	DAZ associated protein 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Bone marrow - Cell proliferation (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.23
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nuclear speckles
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Bone marrow - Cell proliferation

Field

Cluster

Pathway

Number of interactions:

124

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
ZFAND2B	Physical association	High	0.88	2
RHOXF2	Physical association	High	0.85	52
TOLLIP	Physical association	High	0.84	41
BAG3	Physical association	High	0.78	58
C1orf94	Physical association	High	0.78	69
DCUN1D1	Physical association	High	0.78	15
HGS	Physical association	High	0.78	177
RNF208	Physical association	High	0.78	20
RPS27A	Physical association	High	0.78	15
STAM2	Physical association	High	0.78	31
TEX37	Physical association	High	0.78	32
UBAC1	Physical association	High	0.78	24
PEF1	Physical association	High	0.76	26
RNF115	Physical association	High	0.74	10
UBB	Physical association	High	0.74	31
KRTAP19-5	Physical association	High	0.72	82
KRTAP8-1	Physical association	High	0.72	76
OPTN	Physical association	High	0.72	127
OTULIN	Physical association	High	0.72	6
PLEKHB2	Physical association	High	0.72	37
POGZ	Physical association	High	0.72	58
SMAP2	Physical association	High	0.72	10
TAX1BP1	Physical association	High	0.72	58
TNIP3	Physical association	High	0.72	26
UBASH3B	Physical association	High	0.72	25
VHLL	Physical association	High	0.72	4
VPS37C	Physical association	High	0.72	72
ARID5A	Physical association	High	0.7	94
TENT5B	Physical association	High	0.7	57
ZC3H10	Physical association	High	0.7	28
TLE1	Physical association	High	0.67	13
CALCOCO2	Physical association	High	0.67	117
HIP1	Physical association	High	0.67	48
MAGED1	Physical association	High	0.67	79
PLSCR1	Physical association	High	0.67	43
RBFOX2	Physical association	High	0.67	18
RBPMS	Physical association	High	0.67	105
SQSTM1	Physical association	High	0.67	36
UBA52	Physical association	High	0.67	14
UBASH3A	Physical association	High	0.67	7
BATF2	Physical association	High	0.62	10
EXD3	Physical association	High	0.62	1
POLI	Physical association	High	0.62	13
PRR20C	Physical association	High	0.61	20
CELF5	Physical association	High	0.6	19
KRTAP19-3	Physical association	High	0.6	11
SMURF2	Physical association	Medium	0.57	10
AOC1	Physical association	Medium	0.56	8
BHLHE40	Physical association	Medium	0.56	52
CAMK2A	Physical association	Medium	0.56	52
CAPN15	Physical association	Medium	0.56	6
CFAP36	Physical association	Medium	0.56	1
DAB1	Physical association	Medium	0.56	36
DESI1	Physical association	Medium	0.56	21
DTX2	Physical association	Medium	0.56	95
EPN1	Physical association	Medium	0.56	5
ESRP1	Physical association	Medium	0.56	28
FAM168A	Physical association	Medium	0.56	19
FAM83A	Physical association	Medium	0.56	22
FOXD4L1	Physical association	Medium	0.56	17
FOXH1	Physical association	Medium	0.56	48
GPS2	Physical association	Medium	0.56	31
HEMK1	Physical association	Medium	0.56	18
HEY1	Physical association	Medium	0.56	6
HSFY1	Physical association	Medium	0.56	16
HSFY2	Physical association	Medium	0.56	16
HTT	Physical association	Medium	0.56	665
ISX	Physical association	Medium	0.56	5
KLHL42	Physical association	Medium	0.56	24
KRTAP15-1	Physical association	Medium	0.56	53
KRTAP19-1	Physical association	Medium	0.56	36
KRTAP19-7	Physical association	Medium	0.56	71
KRTAP26-1	Physical association	Medium	0.56	73
KRTAP6-1	Physical association	Medium	0.56	70
KRTAP6-2	Physical association	Medium	0.56	136
LITAF	Physical association	Medium	0.56	47
MAPK1IP1L	Physical association	Medium	0.56	19
MINDY3	Physical association	Medium	0.56	6
MTURN	Physical association	Medium	0.56	16
MYEOV	Physical association	Medium	0.56	3
MYOZ3	Physical association	Medium	0.56	44
NAF1	Physical association	Medium	0.56	17
NEDD4L	Physical association	Medium	0.56	5
OTUB2	Physical association	Medium	0.56	17
OTUD7B	Physical association	Medium	0.56	13
PDIK1L	Physical association	Medium	0.56	5
PLEKHF2	Physical association	Medium	0.56	117
PLSCR4	Physical association	Medium	0.56	45
PROP1	Physical association	Medium	0.56	40
PRR13	Physical association	Medium	0.56	37
PRR20D	Physical association	Medium	0.56	55
RABGEF1	Physical association	Medium	0.56	13
RAD18	Physical association	Medium	0.56	12
RAD23A	Physical association	Medium	0.56	41
RAMAC	Physical association	Medium	0.56	37
RBM43	Physical association	Medium	0.56	1
RNF44	Physical association	Medium	0.56	9
ROR2	Physical association	Medium	0.56	24
SNRPC	Physical association	Medium	0.56	43
SOX10	Physical association	Medium	0.56	12
TBX6	Physical association	Medium	0.56	24
TFG	Physical association	Medium	0.56	45
TNIP1	Physical association	Medium	0.56	67
UBAP2	Physical association	Medium	0.56	25
UBC	Physical association	Medium	0.56	56
UBE2D4	Physical association	Medium	0.56	39
UBE2E2	Physical association	Medium	0.56	17
UBE2E3	Physical association	Medium	0.56	24
UBE2V1	Physical association	Medium	0.56	23
UBQLN1	Physical association	Medium	0.56	213
UBQLN2	Physical association	Medium	0.56	212
UBXN6	Physical association	Medium	0.56	11
UBXN7	Physical association	Medium	0.56	22
USP13	Physical association	Medium	0.56	7
USP5	Physical association	Medium	0.56	3
VENTX	Physical association	Medium	0.56	60
VEZF1	Physical association	Medium	0.56	40
YOD1	Physical association	Medium	0.56	17
ZFAND2A	Physical association	Medium	0.56	5
ATXN1	Physical association	Medium	0.51	271
DAZ1	Physical association	Medium	0.51	5
IL17RB	Physical association	Medium	0.51	1
INCA1	Physical association	Medium	0.51	204
LASP1	Physical association	Medium	0.49	21
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
DAZAP2 is not a metabolic protein