Protein interactions for HGS - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HGS
Gene descriptionⁱ Full gene name according to HGNC.	Hepatocyte growth factor-regulated tyrosine kinase substrate
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	40

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Transcription (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.13
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Endosomes, Lysosomes In addition localized to the Cytosol
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Transcription

Field

Cluster

Pathway

Number of interactions:

177

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
LDOC1	Physical association	High	0.85	82
UBC	Direct interaction	High	0.84	56
ODAD1	Physical association	High	0.81	7
DAZAP2	Physical association	High	0.78	124
KRT18	Physical association	High	0.78	26
LITAF	Physical association	High	0.78	47
NMI	Physical association	High	0.78	27
NUP54	Physical association	High	0.78	40
STAM	Physical association	High	0.76	3
MIF4GD	Physical association	High	0.74	9
TSG101	Physical association	High	0.72	50
CDR2	Physical association	High	0.72	68
CRX	Physical association	High	0.72	74
CSTF2	Physical association	High	0.72	23
ING5	Physical association	High	0.72	21
KRT13	Physical association	High	0.72	20
KRT15	Physical association	High	0.72	100
KRT31	Physical association	High	0.72	284
KRT33B	Physical association	High	0.72	65
KRT38	Physical association	High	0.72	57
KRT40	Physical association	High	0.72	288
KRT6A	Physical association	High	0.72	30
MAGED1	Physical association	High	0.72	79
MAPK1IP1L	Physical association	High	0.72	19
MRFAP1L1	Physical association	High	0.72	46
NDC80	Physical association	High	0.72	42
P4HA3	Physical association	High	0.72	39
POGZ	Physical association	High	0.72	58
TEKT1	Physical association	High	0.72	21
TRAF4	Physical association	High	0.72	73
TRIM17	Physical association	High	0.72	3
VPS37B	Physical association	High	0.72	22
ABI2	Physical association	High	0.67	49
BCAS2	Physical association	High	0.67	49
CCDC103	Physical association	High	0.67	17
CEP55	Physical association	High	0.67	56
EXOC7	Physical association	High	0.67	15
INTS4	Physical association	High	0.67	5
KRT19	Physical association	High	0.67	65
LURAP1	Physical association	High	0.67	17
MED7	Physical association	High	0.67	8
USHBP1	Physical association	High	0.67	162
ACTN3	Physical association	Medium	0.56	38
ADRA2C	Physical association	Medium	0.56	10
AKAP8L	Physical association	Medium	0.56	49
ANKRD55	Physical association	Medium	0.56	17
ANTKMT	Physical association	Medium	0.56	10
ARFIP2	Physical association	Medium	0.56	42
ARMC7	Physical association	Medium	0.56	58
BBC3	Physical association	Medium	0.56	12
BFSP2	Physical association	Medium	0.56	44
BICRAL	Physical association	Medium	0.56	13
BLOC1S1	Physical association	Medium	0.56	11
BORCS6	Physical association	Medium	0.56	30
C11orf1	Physical association	Medium	0.56	28
C1orf94	Physical association	Medium	0.56	69
C20orf173	Physical association	Medium	0.56	1
C9orf24	Physical association	Medium	0.56	22
CCND3	Physical association	Medium	0.56	17
CEACAM6	Physical association	Medium	0.56	25
COG8	Physical association	Medium	0.56	6
CSTF2T	Physical association	Medium	0.56	14
CTTNBP2NL	Physical association	Medium	0.56	10
DSN1	Physical association	Medium	0.56	8
DTX2	Physical association	Medium	0.56	95
DYDC1	Physical association	Medium	0.56	24
EFHC2	Physical association	Medium	0.56	79
EGFL7	Physical association	Medium	0.56	4
EIF3F	Physical association	Medium	0.56	42
EXOC3L1	Physical association	Medium	0.56	7
EXOC5	Physical association	Medium	0.56	46
FAM166A	Physical association	Medium	0.56	4
FAM185A	Physical association	Medium	0.56	1
FBN1	Physical association	Medium	0.56	7
FIGN	Physical association	Medium	0.56	2
FNDC11	Physical association	Medium	0.56	37
FOXD4L1	Physical association	Medium	0.56	17
FSD2	Physical association	Medium	0.56	73
FTCD	Physical association	Medium	0.56	5
GATC	Physical association	Medium	0.56	7
GOLGA2	Physical association	Medium	0.56	349
GOLGA6L9	Physical association	Medium	0.56	177
GOLGA7B	Physical association	Medium	0.56	4
GUCA1C	Physical association	Medium	0.56	2
HAP1	Physical association	Medium	0.56	27
HAUS1	Physical association	Medium	0.56	83
HNRNPM	Physical association	Medium	0.56	15
HSFY1	Physical association	Medium	0.56	16
HSFY2	Physical association	Medium	0.56	16
IFNA16	Physical association	Medium	0.56	1
IPO4	Physical association	Medium	0.56	6
JAKMIP2	Physical association	Medium	0.56	13
JMJD7	Physical association	Medium	0.56	14
KIAA0753	Physical association	Medium	0.56	17
KIAA0825	Physical association	Medium	0.56	3
KLF4	Physical association	Medium	0.56	9
KRT14	Physical association	Medium	0.56	21
KRT16	Physical association	Medium	0.56	46
KRT24	Physical association	Medium	0.56	26
KRT25	Physical association	Medium	0.56	22
KRT26	Physical association	Medium	0.56	18
KRT27	Physical association	Medium	0.56	113
KRT3	Physical association	Medium	0.56	33
KRT34	Physical association	Medium	0.56	201
KRT35	Physical association	Medium	0.56	69
KRT37	Physical association	Medium	0.56	36
KRT39	Physical association	Medium	0.56	28
KRT75	Physical association	Medium	0.56	103
KRT76	Physical association	Medium	0.56	33
KRT82	Physical association	Medium	0.56	11
KRT86	Physical association	Medium	0.56	38
KRTAP19-5	Physical association	Medium	0.56	82
KRTAP26-1	Physical association	Medium	0.56	73
KRTAP7-1	Physical association	Medium	0.56	28
LMO1	Physical association	Medium	0.56	88
LMO4	Physical association	Medium	0.56	85
LRRC61	Physical association	Medium	0.56	12
MAGEB4	Physical association	Medium	0.56	29
MED21	Physical association	Medium	0.56	17
MED25	Physical association	Medium	0.56	21
MED30	Physical association	Medium	0.56	8
MED4	Physical association	Medium	0.56	34
METTL27	Physical association	Medium	0.56	41
MKRN3	Physical association	Medium	0.56	118
NADSYN1	Physical association	Medium	0.56	8
NDUFB10	Physical association	Medium	0.56	6
NUP62	Physical association	Medium	0.56	61
ODAM	Physical association	Medium	0.56	9
OIP5	Physical association	Medium	0.56	113
PAX5	Physical association	Medium	0.56	33
PAX6	Physical association	Medium	0.56	79
PEF1	Physical association	Medium	0.56	26
PKNOX2	Physical association	Medium	0.56	29
PLA2G10	Physical association	Medium	0.56	40
PLAAT1	Physical association	Medium	0.56	7
PLCD1	Physical association	Medium	0.56	3
PLEKHB2	Physical association	Medium	0.56	37
POU2AF1	Physical association	Medium	0.56	30
POU6F2	Physical association	Medium	0.56	102
PPP2R3B	Physical association	Medium	0.56	3
PSMB11	Physical association	Medium	0.56	5
PSMB4	Physical association	Medium	0.56	31
RASSF4	Physical association	Medium	0.56	5
RFX6	Physical association	Medium	0.56	24
RNF4	Physical association	Medium	0.56	80
RSPO4	Physical association	Medium	0.56	11
SCT	Physical association	Medium	0.56	2
SDS	Physical association	Medium	0.56	3
SERGEF	Physical association	Medium	0.56	6
SERTAD3	Physical association	Medium	0.56	37
SNX7	Physical association	Medium	0.56	2
SORBS3	Physical association	Medium	0.56	87
SPATA12	Physical association	Medium	0.56	22
SPC25	Physical association	Medium	0.56	6
STK32C	Physical association	Medium	0.56	2
STMN3	Physical association	Medium	0.56	18
STX11	Physical association	Medium	0.56	80
SUMO1	Physical association	Medium	0.56	59
TBX19	Physical association	Medium	0.56	13
TCP11L2	Physical association	Medium	0.56	4
TEKT5	Physical association	Medium	0.56	28
TFG	Physical association	Medium	0.56	45
TIMM10B	Physical association	Medium	0.56	5
TP53BP1	Physical association	Medium	0.56	71
TRAF1	Physical association	Medium	0.56	166
TRIM23	Physical association	Medium	0.56	142
TRIM27	Physical association	Medium	0.56	232
TRIM54	Physical association	Medium	0.56	151
TRIML2	Physical association	Medium	0.56	39
UBAP2	Physical association	Medium	0.56	25
UBQLN2	Physical association	Medium	0.56	212
UBQLNL	Physical association	Medium	0.56	8
VPS37C	Physical association	Medium	0.56	72
VPS52	Physical association	Medium	0.56	83
EGFR	Physical association	Medium	0.54	270
NF2	Physical association	Medium	0.54	28
ARRDC3	Physical association	Medium	0.46	36
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
HGS is not a metabolic protein