Protein interactions for KRT34 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	KRT34
Gene descriptionⁱ Full gene name according to HGNC.	Keratin 34
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Skin - Cornification (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enriched (skin)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.96
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nucleoplasm, Vesicles
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Skin - Cornification

Field

Cluster

Pathway

Number of interactions:

201

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
KRT75	Physical association	High	0.6	103
KRT85	Physical association	High	0.6	22
VENTX	Physical association	High	0.6	60
A1CF	Physical association	Medium	0.56	16
ABHD15	Physical association	Medium	0.56	4
ADRA2C	Physical association	Medium	0.56	10
AGXT	Physical association	Medium	0.56	28
AIMP2	Physical association	Medium	0.56	33
ALDH3B1	Physical association	Medium	0.56	15
ARMC7	Physical association	Medium	0.56	58
ASMTL	Physical association	Medium	0.56	8
ATOSB	Physical association	Medium	0.56	50
ATPAF2	Physical association	Medium	0.56	57
BATF2	Physical association	Medium	0.56	10
BCAS2	Physical association	Medium	0.56	49
BEX1	Physical association	Medium	0.56	12
BEX2	Physical association	Medium	0.56	67
BEX3	Physical association	Medium	0.56	25
BHLHE23	Physical association	Medium	0.56	1
BOLA3	Physical association	Medium	0.56	7
C11orf87	Physical association	Medium	0.56	18
C17orf50	Physical association	Medium	0.56	6
C1orf216	Physical association	Medium	0.56	69
C5orf49	Physical association	Medium	0.56	4
CBX8	Physical association	Medium	0.56	78
CCDC120	Physical association	Medium	0.56	90
CCDC13	Physical association	Medium	0.56	37
CCDC146	Physical association	Medium	0.56	42
CCDC24	Physical association	Medium	0.56	28
CCNC	Physical association	Medium	0.56	69
CDK18	Physical association	Medium	0.56	45
CERK	Physical association	Medium	0.56	19
CFAP206	Physical association	Medium	0.56	46
CFAP53	Physical association	Medium	0.56	23
CHRD	Physical association	Medium	0.56	40
CLEC18A	Physical association	Medium	0.56	5
CTRC	Physical association	Medium	0.56	12
CWC25	Physical association	Medium	0.56	2
CYSRT1	Physical association	Medium	0.56	396
CYTH4	Physical association	Medium	0.56	14
DDIT4L	Physical association	Medium	0.56	168
DDX6	Physical association	Medium	0.56	66
DHRS1	Physical association	Medium	0.56	25
DMRT3	Physical association	Medium	0.56	65
DOCK2	Physical association	Medium	0.56	36
EPDR1	Physical association	Medium	0.56	10
EXOC8	Physical association	Medium	0.56	67
EXOSC5	Physical association	Medium	0.56	42
FAM110A	Physical association	Medium	0.56	41
FAM50B	Physical association	Medium	0.56	39
FAM83A	Physical association	Medium	0.56	22
FAM90A1	Physical association	Medium	0.56	128
FARS2	Physical association	Medium	0.56	56
FBXW5	Physical association	Medium	0.56	21
FNDC11	Physical association	Medium	0.56	37
FOXD4L1	Physical association	Medium	0.56	17
FRS3	Physical association	Medium	0.56	77
GADD45GIP1	Physical association	Medium	0.56	55
GARIN6	Physical association	Medium	0.56	19
GAST	Physical association	Medium	0.56	18
GATAD2A	Physical association	Medium	0.56	5
GEM	Physical association	Medium	0.56	88
GLYCTK	Physical association	Medium	0.56	48
GNG10	Physical association	Medium	0.56	5
GNG13	Physical association	Medium	0.56	21
GPS2	Physical association	Medium	0.56	31
GRN	Physical association	Medium	0.56	216
GSC2	Physical association	Medium	0.56	46
GSTP1	Physical association	Medium	0.56	21
HAPLN2	Physical association	Medium	0.56	36
HBA1	Physical association	Medium	0.56	13
HBA2	Physical association	Medium	0.56	13
HGS	Physical association	Medium	0.56	177
HOXB5	Physical association	Medium	0.56	47
HOXB9	Physical association	Medium	0.56	42
HOXC8	Physical association	Medium	0.56	74
HSPA12B	Physical association	Medium	0.56	10
HSPD1	Physical association	Medium	0.56	35
HYAL2	Physical association	Medium	0.56	12
INIP	Physical association	Medium	0.56	7
INO80B	Physical association	Medium	0.56	49
ISCU	Physical association	Medium	0.56	16
ITGB5	Physical association	Medium	0.56	20
ITPKB	Physical association	Medium	0.56	8
JOSD1	Physical association	Medium	0.56	24
KANK2	Physical association	Medium	0.56	151
KCTD9	Physical association	Medium	0.56	77
KDELR1	Physical association	Medium	0.56	3
KLC4	Physical association	Medium	0.56	18
KLHL38	Physical association	Medium	0.56	72
KLK8	Physical association	Medium	0.56	13
KRT1	Physical association	Medium	0.56	32
KRT20	Physical association	Medium	0.56	32
KRT3	Physical association	Medium	0.56	33
KRT6A	Physical association	Medium	0.56	30
KRT6C	Physical association	Medium	0.56	21
KRT71	Physical association	Medium	0.56	18
KRT74	Physical association	Medium	0.56	14
KRT78	Physical association	Medium	0.56	13
KRT79	Physical association	Medium	0.56	18
KRT8	Physical association	Medium	0.56	20
KRT81	Physical association	Medium	0.56	22
KRT82	Physical association	Medium	0.56	11
KRT83	Physical association	Medium	0.56	31
KRT86	Physical association	Medium	0.56	38
KRTAP12-2	Physical association	Medium	0.56	97
KRTAP19-5	Physical association	Medium	0.56	82
KRTAP19-7	Physical association	Medium	0.56	71
KRTAP26-1	Physical association	Medium	0.56	73
LMO4	Physical association	Medium	0.56	85
LRRC41	Physical association	Medium	0.56	6
LYSMD1	Physical association	Medium	0.56	10
LYVE1	Physical association	Medium	0.56	21
MAB21L2	Physical association	Medium	0.56	11
MAD2L2	Physical association	Medium	0.56	32
MAPKBP1	Physical association	Medium	0.56	48
MATR3	Physical association	Medium	0.56	14
MBD3L2	Physical association	Medium	0.56	7
MIDN	Physical association	Medium	0.56	3
MIIP	Physical association	Medium	0.56	24
MKRN3	Physical association	Medium	0.56	118
MNS1	Physical association	Medium	0.56	23
MOS	Physical association	Medium	0.56	46
MYOZ1	Physical association	Medium	0.56	28
MYOZ3	Physical association	Medium	0.56	44
NAB2	Physical association	Medium	0.56	62
NAXD	Physical association	Medium	0.56	13
NFKBID	Physical association	Medium	0.56	83
NMU	Physical association	Medium	0.56	14
NOTO	Physical association	Medium	0.56	24
NPBWR2	Physical association	Medium	0.56	15
P2RX7	Physical association	Medium	0.56	10
PDGFRB	Physical association	Medium	0.56	21
PGLYRP3	Physical association	Medium	0.56	11
PIN1	Physical association	Medium	0.56	112
PITX1	Physical association	Medium	0.56	50
PKN1	Physical association	Medium	0.56	59
PLLP	Physical association	Medium	0.56	33
POP5	Physical association	Medium	0.56	14
PPP1R18	Physical association	Medium	0.56	68
PPP1R27	Physical association	Medium	0.56	10
PRPF18	Physical association	Medium	0.56	63
PRPF31	Physical association	Medium	0.56	118
PRR35	Physical association	Medium	0.56	57
PSMA1	Physical association	Medium	0.56	135
PSMB1	Physical association	Medium	0.56	83
PTPMT1	Physical association	Medium	0.56	25
R3HDM2	Physical association	Medium	0.56	15
RAB33A	Physical association	Medium	0.56	10
RAB3IL1	Physical association	Medium	0.56	24
RASD1	Physical association	Medium	0.56	23
RFC5	Physical association	Medium	0.56	21
RIN1	Physical association	Medium	0.56	38
RIPPLY1	Physical association	Medium	0.56	28
RTP5	Physical association	Medium	0.56	49
SAMD11	Physical association	Medium	0.56	16
SCNM1	Physical association	Medium	0.56	148
SEC14L4	Physical association	Medium	0.56	19
SEMA4C	Physical association	Medium	0.56	14
SHC3	Physical association	Medium	0.56	31
SLC15A2	Physical association	Medium	0.56	20
SLC22A5	Physical association	Medium	0.56	3
SLC25A42	Physical association	Medium	0.56	3
SMARCD1	Physical association	Medium	0.56	104
SMARCE1	Physical association	Medium	0.56	56
SMCP	Physical association	Medium	0.56	67
SMG9	Physical association	Medium	0.56	32
SPATA46	Physical association	Medium	0.56	10
SPRY3	Physical association	Medium	0.56	22
STMN3	Physical association	Medium	0.56	18
SUOX	Physical association	Medium	0.56	67
TACO1	Physical association	Medium	0.56	15
TAPBPL	Physical association	Medium	0.56	8
TBC1D22B	Physical association	Medium	0.56	46
TCHP	Physical association	Medium	0.56	40
TEKT3	Physical association	Medium	0.56	28
TEKT4	Physical association	Medium	0.56	80
TENT5B	Physical association	Medium	0.56	57
TEPSIN	Physical association	Medium	0.56	101
TFAP2D	Physical association	Medium	0.56	48
THAP7	Physical association	Medium	0.56	47
TLX3	Physical association	Medium	0.56	68
TMEM174	Physical association	Medium	0.56	12
TMSB4X	Physical association	Medium	0.56	10
TRIM42	Physical association	Medium	0.56	112
TRIML2	Physical association	Medium	0.56	39
TSG101	Physical association	Medium	0.56	50
TTC9C	Physical association	Medium	0.56	14
TXLNA	Physical association	Medium	0.56	76
TXLNB	Physical association	Medium	0.56	61
USP2	Physical association	Medium	0.56	78
UTP14C	Physical association	Medium	0.56	17
UTP23	Physical association	Medium	0.56	22
ZDHHC1	Physical association	Medium	0.56	14
ZIC1	Physical association	Medium	0.56	55
ZNF124	Physical association	Medium	0.56	45
ZNF319	Physical association	Medium	0.56	17
ZNF414	Physical association	Medium	0.56	42
ZNF580	Physical association	Medium	0.56	15
ZNF581	Physical association	Medium	0.56	82
ZNF79	Physical association	Medium	0.56	6
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
KRT34 is not a metabolic protein