Protein interactions for FAM90A1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FAM90A1
Gene descriptionⁱ Full gene name according to HGNC.	Family with sequence similarity 90 member A1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Neuronal - Synaptic function (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enhanced (brain)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.64
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nucleoplasm In addition localized to the Nucleoli
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Neuronal - Synaptic function

Field

Cluster

Pathway

Number of interactions:

128

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
GOLGA2	Physical association	High	0.79	349
CALCOCO2	Physical association	High	0.78	117
FHL3	Physical association	High	0.78	103
ZNF212	Physical association	High	0.78	13
CEP55	Physical association	High	0.72	56
CEP76	Physical association	High	0.72	79
EXOSC8	Physical association	High	0.72	46
FSD2	Physical association	High	0.72	73
KRT31	Physical association	High	0.72	284
KRT40	Physical association	High	0.72	288
LDOC1	Physical association	High	0.72	82
PSTPIP1	Physical association	High	0.72	42
STAC3	Physical association	High	0.72	30
TRAF2	Physical association	High	0.72	237
TRIM23	Physical association	High	0.72	142
COG6	Physical association	High	0.7	49
KPNA3	Physical association	High	0.67	32
BRD4	Physical association	High	0.65	5
ACTN3	Physical association	Medium	0.56	38
AMOTL2	Physical association	Medium	0.56	38
ANKRD23	Physical association	Medium	0.56	17
ANKRD29	Physical association	Medium	0.56	7
AP2M1	Physical association	Medium	0.56	38
ARHGEF9	Physical association	Medium	0.56	10
ARRDC3	Physical association	Medium	0.56	36
BANP	Physical association	Medium	0.56	58
BCAR1	Physical association	Medium	0.56	19
BEGAIN	Physical association	Medium	0.56	29
BLZF1	Physical association	Medium	0.56	84
CCDC13	Physical association	Medium	0.56	37
CCDC57	Physical association	Medium	0.56	32
CCN3	Physical association	Medium	0.56	12
CCNC	Physical association	Medium	0.56	69
CDR2	Physical association	Medium	0.56	68
CEP70	Physical association	Medium	0.56	196
CEP72	Physical association	Medium	0.56	19
CYSRT1	Physical association	Medium	0.56	396
DTX3	Physical association	Medium	0.56	20
DVL3	Physical association	Medium	0.56	120
EFEMP2	Physical association	Medium	0.56	83
ENKD1	Physical association	Medium	0.56	159
FAM228A	Physical association	Medium	0.56	15
FLOT1	Physical association	Medium	0.56	9
FOSB	Physical association	Medium	0.56	20
FXR2	Physical association	Medium	0.56	58
GABPB1	Physical association	Medium	0.56	16
GCSAML	Physical association	Medium	0.56	7
GNPTAB	Physical association	Medium	0.56	6
GOPC	Physical association	Medium	0.56	28
GPRASP3	Physical association	Medium	0.56	49
GRIPAP1	Physical association	Medium	0.56	46
HMBOX1	Physical association	Medium	0.56	76
HOMER3	Physical association	Medium	0.56	65
HSF2BP	Physical association	Medium	0.56	223
ISY1	Physical association	Medium	0.56	13
KANK2	Physical association	Medium	0.56	151
KASH5	Physical association	Medium	0.56	96
KLHL12	Physical association	Medium	0.56	40
KPNA6	Physical association	Medium	0.56	17
KRT34	Physical association	Medium	0.56	201
KRT38	Physical association	Medium	0.56	57
KRTAP1-1	Physical association	Medium	0.56	150
KRTAP10-8	Physical association	Medium	0.56	325
LHX6	Physical association	Medium	0.56	18
LNX1	Physical association	Medium	0.56	333
LRP2BP	Physical association	Medium	0.56	17
LZTS1	Physical association	Medium	0.56	73
LZTS2	Physical association	Medium	0.56	178
MAD1L1	Physical association	Medium	0.56	38
MDFI	Physical association	Medium	0.56	277
MIPOL1	Physical association	Medium	0.56	58
MLH1	Physical association	Medium	0.56	54
MORN3	Physical association	Medium	0.56	57
MSS51	Physical association	Medium	0.56	19
MTUS2	Physical association	Medium	0.56	130
MYOG	Physical association	Medium	0.56	27
NDUFB7	Physical association	Medium	0.56	27
NOTCH2NLC	Physical association	Medium	0.56	178
NUDT21	Physical association	Medium	0.56	20
OVOL1	Physical association	Medium	0.56	2
PBX1	Physical association	Medium	0.56	11
PBX2	Physical association	Medium	0.56	19
PDLIM7	Physical association	Medium	0.56	31
PFDN5	Physical association	Medium	0.56	81
PICK1	Physical association	Medium	0.56	275
PIH1D1	Physical association	Medium	0.56	19
PLAGL2	Physical association	Medium	0.56	36
PPP1R13B	Physical association	Medium	0.56	54
PRDM6	Physical association	Medium	0.56	48
PRKAR1B	Physical association	Medium	0.56	55
PRR23B	Physical association	Medium	0.56	3
RAB11FIP2	Physical association	Medium	0.56	10
RABEP1	Physical association	Medium	0.56	39
RBM48	Physical association	Medium	0.56	21
RHOH	Physical association	Medium	0.56	11
RINT1	Physical association	Medium	0.56	68
ROPN1	Physical association	Medium	0.56	37
SIAH1	Physical association	Medium	0.56	88
SMAD3	Physical association	Medium	0.56	52
SNW1	Physical association	Medium	0.56	89
SPRED1	Physical association	Medium	0.56	308
STMN2	Physical association	Medium	0.56	7
STX11	Physical association	Medium	0.56	80
TAX1BP1	Physical association	Medium	0.56	58
TEPSIN	Physical association	Medium	0.56	101
TFIP11	Physical association	Medium	0.56	179
TRIB3	Physical association	Medium	0.56	54
TRIM27	Physical association	Medium	0.56	232
TRIM42	Physical association	Medium	0.56	112
TRIM54	Physical association	Medium	0.56	151
TRIM9	Physical association	Medium	0.56	18
TRIML2	Physical association	Medium	0.56	39
VRTN	Physical association	Medium	0.56	9
VWC2	Physical association	Medium	0.56	51
ZBTB14	Physical association	Medium	0.56	54
ZBTB16	Physical association	Medium	0.56	43
ZBTB8A	Physical association	Medium	0.56	58
ZMYND12	Physical association	Medium	0.56	66
ZNF143	Physical association	Medium	0.56	16
ZNF343	Physical association	Medium	0.56	18
ZNF526	Physical association	Medium	0.56	45
ZNF581	Physical association	Medium	0.56	82
ZNF655	Physical association	Medium	0.56	117
ZNF688	Physical association	Medium	0.56	28
ZNF76	Physical association	Medium	0.56	62
ZWINT	Physical association	Medium	0.56	21
DVL2	Physical association	Medium	0.49	43
PSME3	Physical association	Medium	0.49	35
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
FAM90A1 is not a metabolic protein