Protein interactions for DVL3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DVL3
Gene descriptionⁱ Full gene name according to HGNC.	Dishevelled segment polarity protein 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Smooth muscle tissue - ECM organization (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.13
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Cytosol
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Smooth muscle tissue - ECM organization

Field

Cluster

Pathway

Number of interactions:

120

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
CSNK1E	Physical association	High	0.81	16
YTHDC1	Physical association	High	0.72	16
WT1	Physical association	High	0.67	4
CSNK2A1	Physical association	High	0.67	54
BAHD1	Physical association	High	0.67	54
CSNK1D	Physical association	High	0.67	15
KLHL12	Physical association	High	0.67	40
PITX1	Physical association	High	0.67	50
TNFAIP8L1	Physical association	High	0.67	11
ZBTB48	Physical association	High	0.67	23
ZNF408	Physical association	High	0.67	51
DVL1	Direct interaction	High	0.63	7
ABT1	Physical association	Medium	0.56	13
ADAP1	Physical association	Medium	0.56	5
AKAP17A	Physical association	Medium	0.56	8
AP3M1	Physical association	Medium	0.56	10
APP	Physical association	Medium	0.56	312
BHLHE40	Physical association	Medium	0.56	52
C1orf35	Physical association	Medium	0.56	32
CBX8	Physical association	Medium	0.56	78
CCNL1	Physical association	Medium	0.56	16
CDYL2	Physical association	Medium	0.56	6
CEP57L1	Physical association	Medium	0.56	27
CEP70	Physical association	Medium	0.56	196
CEP76	Physical association	Medium	0.56	79
CT45A10	Physical association	Medium	0.56	4
CT45A3	Physical association	Medium	0.56	3
CYSRT1	Physical association	Medium	0.56	396
EIF1B	Physical association	Medium	0.56	4
EIF3D	Physical association	Medium	0.56	27
FAM13C	Physical association	Medium	0.56	12
FAM90A1	Physical association	Medium	0.56	128
FARS2	Physical association	Medium	0.56	56
FGF16	Physical association	Medium	0.56	6
GADD45GIP1	Physical association	Medium	0.56	55
HOMER3	Physical association	Medium	0.56	65
HOXA5	Physical association	Medium	0.56	4
HOXC5	Physical association	Medium	0.56	9
HOXC8	Physical association	Medium	0.56	74
INO80B	Physical association	Medium	0.56	49
JPH3	Physical association	Medium	0.56	146
KCTD10	Physical association	Medium	0.56	6
KLF1	Physical association	Medium	0.56	14
KLF15	Physical association	Medium	0.56	30
KLF3	Physical association	Medium	0.56	28
KLF4	Physical association	Medium	0.56	9
LENG8	Physical association	Medium	0.56	35
LONRF1	Physical association	Medium	0.56	77
LUZP4	Physical association	Medium	0.56	19
MAB21L3	Physical association	Medium	0.56	24
MAGEB4	Physical association	Medium	0.56	29
MAGOHB	Physical association	Medium	0.56	56
NKD1	Physical association	Medium	0.56	11
NOL12	Physical association	Medium	0.56	10
NXF1	Physical association	Medium	0.56	62
PHF19	Physical association	Medium	0.56	24
PLAGL2	Physical association	Medium	0.56	36
PNKP	Physical association	Medium	0.56	34
PPP1R16B	Physical association	Medium	0.56	31
PRKAA2	Physical association	Medium	0.56	78
PRPF18	Physical association	Medium	0.56	63
PRPF31	Physical association	Medium	0.56	118
PRPF38A	Physical association	Medium	0.56	19
PRPS1	Physical association	Medium	0.56	79
PRR13	Physical association	Medium	0.56	37
PRR20D	Physical association	Medium	0.56	55
PSME3	Physical association	Medium	0.56	35
RBM39	Physical association	Medium	0.56	23
RNF151	Physical association	Medium	0.56	11
RRP8	Physical association	Medium	0.56	4
RWDD2B	Physical association	Medium	0.56	9
SAP30L	Physical association	Medium	0.56	2
SNIP1	Physical association	Medium	0.56	21
SORBS3	Physical association	Medium	0.56	87
STOM	Physical association	Medium	0.56	120
SUV39H1	Physical association	Medium	0.56	52
SYTL4	Physical association	Medium	0.56	19
TBPL1	Physical association	Medium	0.56	7
TCEA2	Physical association	Medium	0.56	88
TFG	Physical association	Medium	0.56	45
THAP7	Physical association	Medium	0.56	47
TNP1	Physical association	Medium	0.56	2
TRAF2	Physical association	Medium	0.56	237
TRIM41	Physical association	Medium	0.56	108
TSN	Physical association	Medium	0.56	10
TSPYL6	Physical association	Medium	0.56	9
UTP3	Physical association	Medium	0.56	4
WFS1	Physical association	Medium	0.56	315
XPA	Physical association	Medium	0.56	17
ZBTB24	Physical association	Medium	0.56	52
ZBTB26	Physical association	Medium	0.56	27
ZBTB47	Physical association	Medium	0.56	7
ZBTB8A	Physical association	Medium	0.56	58
ZNF165	Physical association	Medium	0.56	31
ZNF2	Physical association	Medium	0.56	4
ZNF264	Physical association	Medium	0.56	14
ZNF319	Physical association	Medium	0.56	17
ZNF417	Physical association	Medium	0.56	140
ZNF441	Physical association	Medium	0.56	7
ZNF497	Physical association	Medium	0.56	41
ZNF552	Physical association	Medium	0.56	27
ZNF581	Physical association	Medium	0.56	82
ZNF648	Physical association	Medium	0.56	50
ZNF696	Physical association	Medium	0.56	30
ZNF699	Physical association	Medium	0.56	6
ZNF71	Physical association	Medium	0.56	18
ZNF764	Physical association	Medium	0.56	26
ZNF774	Physical association	Medium	0.56	68
ZNF775	Physical association	Medium	0.56	9
ZNF792	Physical association	Medium	0.56	46
ZNF837	Physical association	Medium	0.56	68
ZRSR2	Physical association	Medium	0.56	13
ZSCAN21	Physical association	Medium	0.56	22
ZSCAN22	Physical association	Medium	0.56	27
CEP164	Physical association	Medium	0.56	4
LNX1	Physical association	Medium	0.55	333
LRRK2	Physical association	Medium	0.54	108
SIRT1	Physical association	Medium	0.52	44
PRPF3	Physical association	Medium	0.51	35
FUZ	Physical association	Medium	0.46	3
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
DVL3 is not a metabolic protein