Protein interactions for LRRK2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	LRRK2
Gene descriptionⁱ Full gene name according to HGNC.	Leucine rich repeat kinase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes Disease related genes Enzymes Human disease related genes Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Lung - Lung function (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enriched (lung)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.60
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Vesicles
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Lung - Lung function

Field

Cluster

Pathway

Number of interactions:

108

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
MSN	Direct interaction	High	0.96	4
YWHAZ	Direct interaction	High	0.91	128
DNM1L	Physical association	High	0.88	7
YWHAQ	Direct interaction	High	0.86	54
CDC37	Physical association	High	0.85	124
YWHAE	Physical association	High	0.82	42
YWHAG	Direct interaction	High	0.82	241
HSPA8	Physical association	High	0.81	35
PRDX3	Physical association	High	0.8	4
GAK	Direct interaction	High	0.79	3
RPS15	Direct interaction	High	0.78	4
RAB5B	Direct interaction	High	0.76	4
RAB29	Direct interaction	High	0.76	4
RAB32	Direct interaction	High	0.75	3
YWHAB	Direct interaction	High	0.75	78
TUBB	Physical association	High	0.74	17
CHGB	Direct interaction	High	0.73	1
YWHAH	Physical association	High	0.72	31
BAG5	Direct interaction	High	0.72	13
ARHGEF7	Direct interaction	High	0.72	14
ECHS1	Direct interaction	High	0.71	3
SFN	Direct interaction	High	0.71	39
STUB1	Direct interaction	High	0.71	54
RAB8A	Direct interaction	High	0.7	18
NUP133	Direct interaction	High	0.69	6
RPS20	Direct interaction	High	0.69	5
RAB10	Direct interaction	High	0.69	6
CBLB	Direct interaction	High	0.68	25
TUBB4A	Physical association	High	0.67	2
SQSTM1	Direct interaction	High	0.67	36
SNAPIN	Direct interaction	High	0.66	36
LRP6	Physical association	High	0.66	12
SEC16A	Physical association	High	0.65	5
GSK3B	Direct interaction	High	0.65	28
RPL10A	Direct interaction	High	0.64	4
RPL13	Direct interaction	High	0.64	7
RPS11	Direct interaction	High	0.64	3
RPS16	Direct interaction	High	0.64	2
RPS2	Direct interaction	High	0.64	5
RPS27	Direct interaction	High	0.64	6
RPS3	Direct interaction	High	0.64	14
PPP2R2A	Physical association	High	0.64	9
PPP1CA	Direct interaction	High	0.64	87
DVL2	Physical association	High	0.63	43
ANKS4B	Direct interaction	High	0.62	1
BAG2	Direct interaction	High	0.62	12
CDC42EP3	Direct interaction	High	0.62	2
CUEDC1	Direct interaction	High	0.62	6
MATK	Direct interaction	High	0.62	6
NDUFAF7	Direct interaction	High	0.62	1
NEK1	Direct interaction	High	0.62	7
PAK6	Direct interaction	High	0.62	6
SH3GL2	Direct interaction	High	0.62	16
LMNB1	Physical association	High	0.62	15
CDC42	Physical association	High	0.62	31
OPA1	Physical association	High	0.6	5
AHCYL1	Direct interaction	Medium	0.59	27
CFAP20	Direct interaction	Medium	0.59	21
LARP4	Direct interaction	Medium	0.59	2
LARP7	Direct interaction	Medium	0.59	4
MRPL19	Direct interaction	Medium	0.59	1
PPP1R8	Direct interaction	Medium	0.59	5
PRKACA	Direct interaction	Medium	0.59	41
RAB1B	Direct interaction	Medium	0.59	4
RPL30	Direct interaction	Medium	0.59	2
RPL34	Direct interaction	Medium	0.59	2
RPS13	Direct interaction	Medium	0.59	5
RPS18	Direct interaction	Medium	0.59	4
SH3GL1	Direct interaction	Medium	0.59	21
TCF25	Direct interaction	Medium	0.59	9
TTC27	Direct interaction	Medium	0.59	1
USP39	Direct interaction	Medium	0.59	5
ZRANB2	Direct interaction	Medium	0.59	5
LRRK1	Physical association	Medium	0.59	4
MAP2K3	Physical association	Medium	0.59	5
RGS2	Direct interaction	Medium	0.57	15
AGO2	Physical association	Medium	0.56	28
AP3B1	Physical association	Medium	0.56	5
EEF1A2	Physical association	Medium	0.56	6
LMNB2	Physical association	Medium	0.56	22
SLC25A4	Physical association	Medium	0.56	2
SLC25A5	Physical association	Medium	0.56	1
SLC25A6	Physical association	Medium	0.56	12
VDAC1	Physical association	Medium	0.56	13
AKT1	Direct interaction	Medium	0.56	58
RAB38	Direct interaction	Medium	0.56	9
NFATC2	Physical association	Medium	0.56	2
RPP25	Physical association	Medium	0.56	25
SEM1	Physical association	Medium	0.56	11
SPATA22	Physical association	Medium	0.56	16
RAC1	Physical association	Medium	0.56	59
SNCA	Physical association	Medium	0.56	124
ARFGAP1	Direct interaction	Medium	0.55	7
TUBB2A	Physical association	Medium	0.55	9
TUBB4B	Physical association	Medium	0.55	1
TUBB6	Physical association	Medium	0.55	4
DNM1	Physical association	Medium	0.54	10
DVL3	Physical association	Medium	0.54	120
WSB1	Physical association	Medium	0.54	1
LDHB	Direct interaction	Medium	0.52	7
RPL14	Direct interaction	Medium	0.52	5
RPL23A	Direct interaction	Medium	0.52	3
RPS23	Direct interaction	Medium	0.52	3
FADD	Physical association	Medium	0.5	17
TUBB3	Physical association	Medium	0.48	4
LAMP2	Physical association	Medium	0.46	1
MAP2K6	Physical association	Medium	0.46	7
MFN2	Physical association	Medium	0.46	4
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
LRRK2 is not a metabolic protein