Protein interactions for YWHAG - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	YWHAG
Gene descriptionⁱ Full gene name according to HGNC.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Basic cellular processes (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enhanced (brain, skeletal muscle)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.32
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Cytosol
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Basic cellular processes

Field

Cluster

Pathway

Number of interactions:

241

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
HDAC4	Physical association	High	0.93	22
RAF1	Physical association	High	0.89	40
YWHAE	Direct interaction	High	0.88	42
ARAF	Physical association	High	0.86	14
BRAF	Physical association	High	0.86	14
PTPN3	Physical association	High	0.82	22
MARK3	Physical association	High	0.82	9
LRRK2	Direct interaction	High	0.82	108
KIF23	Physical association	High	0.81	8
PAK4	Physical association	High	0.81	7
YAP1	Physical association	High	0.81	31
EPB41L3	Physical association	High	0.76	5
RMDN3	Physical association	High	0.76	23
SH3BP4	Physical association	High	0.76	8
CLK3	Physical association	High	0.76	34
FRMD6	Physical association	High	0.76	12
HDAC7	Physical association	High	0.76	6
RACGAP1	Physical association	High	0.76	13
ABL1	Physical association	High	0.74	30
MAP3K2	Physical association	High	0.74	6
FAM53C	Physical association	High	0.74	5
TSC2	Direct interaction	High	0.72	9
MDM4	Direct interaction	High	0.7	22
YWHAB	Direct interaction	High	0.69	78
AFDN	Physical association	High	0.69	7
AKAP13	Physical association	High	0.69	5
ANKS1A	Physical association	High	0.69	3
ARHGEF2	Physical association	High	0.69	7
ARHGEF7	Physical association	High	0.69	14
BAIAP2	Physical association	High	0.69	12
BCLAF1	Physical association	High	0.69	3
CDK17	Physical association	High	0.69	6
CGN	Physical association	High	0.69	3
CLASP1	Physical association	High	0.69	3
CLK2	Physical association	High	0.69	45
DENND4A	Physical association	High	0.69	4
DYRK1A	Physical association	High	0.69	12
EDC3	Physical association	High	0.69	12
EML3	Physical association	High	0.69	5
ERC1	Physical association	High	0.69	2
GSK3A	Physical association	High	0.69	12
IRS2	Physical association	High	0.69	7
KIAA0930	Physical association	High	0.69	4
KIF1B	Physical association	High	0.69	3
KIF5B	Physical association	High	0.69	17
KLC2	Physical association	High	0.69	4
LSR	Physical association	High	0.69	2
LUC7L2	Physical association	High	0.69	16
MICALL1	Physical association	High	0.69	7
MPRIP	Physical association	High	0.69	7
MYCBP2	Physical association	High	0.69	3
NADK	Physical association	High	0.69	6
NOLC1	Physical association	High	0.69	4
OSBPL3	Physical association	High	0.69	22
PI4KB	Physical association	High	0.69	4
PIK3C3	Physical association	High	0.69	6
PPFIBP1	Physical association	High	0.69	5
PRPF4B	Physical association	High	0.69	6
RAB11FIP2	Physical association	High	0.69	10
RABEP1	Physical association	High	0.69	39
RABGEF1	Physical association	High	0.69	13
RAI14	Physical association	High	0.69	5
RALGPS2	Physical association	High	0.69	4
RASAL2	Physical association	High	0.69	4
RASSF8	Physical association	High	0.69	1
SAMD4A	Physical association	High	0.69	3
SF3B3	Physical association	High	0.69	9
SH3BP5L	Physical association	High	0.69	10
SHCBP1	Physical association	High	0.69	2
SRGAP2	Physical association	High	0.69	7
SRRM1	Physical association	High	0.69	4
SRRM2	Physical association	High	0.69	4
SRSF10	Physical association	High	0.69	4
TIAM1	Physical association	High	0.69	3
TJP2	Physical association	High	0.69	5
TSC1	Physical association	High	0.69	12
USP8	Physical association	High	0.69	10
ZBTB21	Physical association	High	0.69	1
EPB41L2	Physical association	High	0.68	2
MAP3K3	Physical association	High	0.67	16
MARK2	Physical association	High	0.67	9
MACIR	Physical association	High	0.67	6
RIMS3	Physical association	High	0.67	5
BAD	Physical association	High	0.66	16
CENPJ	Physical association	High	0.64	7
CHEK1	Direct interaction	High	0.6	7
YWHAQ	Direct interaction	Medium	0.59	54
ACIN1	Physical association	Medium	0.59	6
CCNY	Physical association	Medium	0.59	3
CDC5L	Physical association	Medium	0.59	48
CFAP20	Physical association	Medium	0.59	21
DFFA	Physical association	Medium	0.59	4
GBF1	Physical association	Medium	0.59	2
IGF1R	Physical association	Medium	0.59	21
LARP1	Physical association	Medium	0.59	5
LBR	Physical association	Medium	0.59	4
LUC7L3	Physical association	Medium	0.59	1
MFAP1	Physical association	Medium	0.59	79
PABPC1	Physical association	Medium	0.59	23
PIK3R1	Physical association	Medium	0.59	41
PNN	Physical association	Medium	0.59	6
PPIG	Physical association	Medium	0.59	13
PRPF19	Physical association	Medium	0.59	9
PRPF38B	Physical association	Medium	0.59	1
PUF60	Physical association	Medium	0.59	20
RNPS1	Physical association	Medium	0.59	46
SNRNP200	Physical association	Medium	0.59	12
SON	Physical association	Medium	0.59	1
SRPK1	Physical association	Medium	0.59	25
THRAP3	Physical association	Medium	0.59	7
TMEM102	Physical association	Medium	0.59	4
TRA2B	Physical association	Medium	0.59	16
ARHGEF16	Physical association	Medium	0.56	8
CAMSAP2	Physical association	Medium	0.56	2
CDK16	Physical association	Medium	0.56	6
CLK1	Physical association	Medium	0.56	3
CRTC2	Physical association	Medium	0.56	7
EPB41	Physical association	Medium	0.56	1
FRYL	Physical association	Medium	0.56	2
KIF5C	Physical association	Medium	0.56	6
KLC1	Physical association	Medium	0.56	6
KLC4	Physical association	Medium	0.56	18
MAP3K20	Physical association	Medium	0.56	4
MAPKAP1	Physical association	Medium	0.56	3
MARK1	Physical association	Medium	0.56	5
NCKAP1	Physical association	Medium	0.56	7
PANK2	Physical association	Medium	0.56	2
PARD3	Physical association	Medium	0.56	15
PFKFB2	Physical association	Medium	0.56	2
PPP1R3D	Physical association	Medium	0.56	3
SAMD4B	Physical association	Medium	0.56	9
SFN	Physical association	Medium	0.56	39
SRSF1	Physical association	Medium	0.56	13
TBC1D1	Physical association	Medium	0.56	24
TRA2A	Physical association	Medium	0.56	5
WEE1	Physical association	Medium	0.56	6
ZNF638	Physical association	Medium	0.56	1
HIVEP3	Direct interaction	Medium	0.56	2
ACAP1	Physical association	Medium	0.56	7
ACOT13	Physical association	Medium	0.56	5
ARHGEF9	Physical association	Medium	0.56	10
ASB1	Physical association	Medium	0.56	3
BAAT	Physical association	Medium	0.56	9
C16orf87	Physical association	Medium	0.56	5
CCDC47	Physical association	Medium	0.56	6
CCDC90B	Physical association	Medium	0.56	6
CENPV	Physical association	Medium	0.56	14
CEP76	Physical association	Medium	0.56	79
CHCHD3	Physical association	Medium	0.56	37
CIB1	Physical association	Medium	0.56	20
CPN1	Physical association	Medium	0.56	4
CTSO	Physical association	Medium	0.56	3
DEXI	Physical association	Medium	0.56	8
DNPH1	Physical association	Medium	0.56	5
DRD1	Physical association	Medium	0.56	4
EIF3E	Physical association	Medium	0.56	26
FSCN2	Physical association	Medium	0.56	3
GNA14	Physical association	Medium	0.56	3
GPR160	Physical association	Medium	0.56	2
GPRASP2	Physical association	Medium	0.56	23
H4C1	Physical association	Medium	0.56	54
H4C11	Physical association	Medium	0.56	54
H4C12	Physical association	Medium	0.56	54
H4C13	Physical association	Medium	0.56	54
H4C14	Physical association	Medium	0.56	54
H4C15	Physical association	Medium	0.56	54
H4C16	Physical association	Medium	0.56	54
H4C2	Physical association	Medium	0.56	54
H4C3	Physical association	Medium	0.56	54
H4C4	Physical association	Medium	0.56	54
H4C5	Physical association	Medium	0.56	54
H4C6	Physical association	Medium	0.56	54
H4C8	Physical association	Medium	0.56	54
H4C9	Physical association	Medium	0.56	54
HAX1	Physical association	Medium	0.56	11
HNRNPF	Physical association	Medium	0.56	45
HOXB13	Physical association	Medium	0.56	3
HOXC4	Physical association	Medium	0.56	22
ID2	Physical association	Medium	0.56	20
IGBP1	Physical association	Medium	0.56	8
IGFBP3	Physical association	Medium	0.56	5
IL3RA	Physical association	Medium	0.56	17
KCTD17	Physical association	Medium	0.56	29
KLF12	Physical association	Medium	0.56	9
KRTAP3-1	Physical association	Medium	0.56	61
LHX5	Physical association	Medium	0.56	17
LIPT1	Physical association	Medium	0.56	4
LUM	Physical association	Medium	0.56	4
MAGEH1	Physical association	Medium	0.56	7
MAP3K9	Physical association	Medium	0.56	4
MAPK11	Physical association	Medium	0.56	14
METTL7A	Physical association	Medium	0.56	7
MNDA	Physical association	Medium	0.56	11
NDUFA5	Physical association	Medium	0.56	9
NDUFV1	Physical association	Medium	0.56	17
NHSL2	Physical association	Medium	0.56	19
PDCD2	Physical association	Medium	0.56	5
PELO	Physical association	Medium	0.56	20
PIAS3	Physical association	Medium	0.56	6
PIP4P1	Physical association	Medium	0.56	5
POLI	Physical association	Medium	0.56	13
PROS1	Physical association	Medium	0.56	4
RCC1L	Physical association	Medium	0.56	3
RHOBTB1	Physical association	Medium	0.56	3
RNF114	Physical association	Medium	0.56	6
RPL35A	Physical association	Medium	0.56	5
SDHC	Physical association	Medium	0.56	3
SEPTIN6	Physical association	Medium	0.56	17
SNW1	Physical association	Medium	0.56	89
SNX10	Physical association	Medium	0.56	6
SNX33	Physical association	Medium	0.56	12
SOX10	Physical association	Medium	0.56	12
STIM1	Physical association	Medium	0.56	20
SYNGR3	Physical association	Medium	0.56	15
TCF4	Physical association	Medium	0.56	124
TFAP2B	Physical association	Medium	0.56	2
TMEM176B	Physical association	Medium	0.56	4
TMEM54	Physical association	Medium	0.56	19
TPMT	Physical association	Medium	0.56	1
TRMT6	Physical association	Medium	0.56	3
TSNAX	Physical association	Medium	0.56	36
USP38	Physical association	Medium	0.56	3
VAMP3	Physical association	Medium	0.56	46
VNN2	Physical association	Medium	0.56	3
ZFYVE21	Physical association	Medium	0.56	22
ZKSCAN8	Physical association	Medium	0.56	14
ZMYM3	Physical association	Medium	0.56	2
ZNF346	Physical association	Medium	0.56	9
ZSCAN9	Physical association	Medium	0.56	21
TERF1	Physical association	Medium	0.55	71
CEP95	Physical association	Medium	0.55	13
CGNL1	Physical association	Medium	0.55	1
CRTC3	Physical association	Medium	0.55	4
HIVEP2	Physical association	Medium	0.55	1
ITPRID2	Physical association	Medium	0.55	3
NEDD4L	Physical association	Medium	0.55	5
RAB11A	Physical association	Medium	0.55	11
WNK1	Physical association	Medium	0.55	5
WWTR1	Physical association	Medium	0.55	17
TINF2	Physical association	Medium	0.51	48
CFL1	Physical association	Medium	0.5	12
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
YWHAG is not a metabolic protein