Protein interactions for MFAP1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MFAP1
Gene descriptionⁱ Full gene name according to HGNC.	Microfibril associated protein 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Mitochondria (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.14
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nucleoplasm In addition localized to the Centrosome
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Mitochondria

Field

Cluster

Pathway

Number of interactions:

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
KATNBL1	Physical association	High	0.78	31
ZNF398	Physical association	High	0.78	16
CEP55	Physical association	High	0.72	56
CEP70	Physical association	High	0.72	196
FXR2	Physical association	High	0.72	58
GOLGA2	Physical association	High	0.72	349
HMBOX1	Physical association	High	0.72	76
LDOC1	Physical association	High	0.72	82
MAD1L1	Physical association	High	0.72	38
TRIM54	Physical association	High	0.72	151
VPS52	Physical association	High	0.72	83
SNIP1	Physical association	High	0.67	21
YWHAG	Physical association	Medium	0.59	241
AMOTL2	Physical association	Medium	0.56	38
AP2M1	Physical association	Medium	0.56	38
BLZF1	Physical association	Medium	0.56	84
CARD9	Physical association	Medium	0.56	52
CCDC102B	Physical association	Medium	0.56	87
CCDC57	Physical association	Medium	0.56	32
CDC14B	Physical association	Medium	0.56	7
CDCA7L	Physical association	Medium	0.56	52
CEP57L1	Physical association	Medium	0.56	27
CEP76	Physical association	Medium	0.56	79
COG6	Physical association	Medium	0.56	49
COIL	Physical association	Medium	0.56	35
DNTTIP1	Physical association	Medium	0.56	11
FAM9B	Physical association	Medium	0.56	118
GAS8	Physical association	Medium	0.56	97
GKAP1	Physical association	Medium	0.56	11
GMCL1	Physical association	Medium	0.56	50
GOLGA6L9	Physical association	Medium	0.56	177
GPRASP3	Physical association	Medium	0.56	49
GRIPAP1	Physical association	Medium	0.56	46
HOMER3	Physical association	Medium	0.56	65
HSF2BP	Physical association	Medium	0.56	223
KIFC3	Physical association	Medium	0.56	70
KLHL2	Physical association	Medium	0.56	23
KRT40	Physical association	Medium	0.56	288
LMNB2	Physical association	Medium	0.56	22
LZTS1	Physical association	Medium	0.56	73
MCRS1	Physical association	Medium	0.56	97
MIPOL1	Physical association	Medium	0.56	58
MTUS2	Physical association	Medium	0.56	130
NDC80	Physical association	Medium	0.56	42
NGDN	Physical association	Medium	0.56	4
OLIG3	Physical association	Medium	0.56	24
PAX6	Physical association	Medium	0.56	79
PHC2	Physical association	Medium	0.56	47
PIH1D1	Physical association	Medium	0.56	19
PINX1	Physical association	Medium	0.56	15
PLEKHF2	Physical association	Medium	0.56	117
SSX2IP	Physical association	Medium	0.56	78
STAC3	Physical association	Medium	0.56	30
STX11	Physical association	Medium	0.56	80
TCP10L	Physical association	Medium	0.56	28
TEPSIN	Physical association	Medium	0.56	101
TFIP11	Physical association	Medium	0.56	179
THAP1	Physical association	Medium	0.56	81
TLE5	Physical association	Medium	0.56	105
TNNI1	Physical association	Medium	0.56	29
TRAF2	Physical association	Medium	0.56	237
TRIM41	Physical association	Medium	0.56	108
TRIM42	Physical association	Medium	0.56	112
ZBTB1	Physical association	Medium	0.56	13
ZBTB14	Physical association	Medium	0.56	54
ZBTB8A	Physical association	Medium	0.56	58
ZFP1	Physical association	Medium	0.56	17
ZFP41	Physical association	Medium	0.56	6
ZFP64	Physical association	Medium	0.56	14
ZNF134	Physical association	Medium	0.56	3
ZNF212	Physical association	Medium	0.56	13
ZNF558	Physical association	Medium	0.56	10
ZNF620	Physical association	Medium	0.56	51
ZNF71	Physical association	Medium	0.56	18
ZNF76	Physical association	Medium	0.56	62
ZRANB1	Physical association	Medium	0.56	112
PRPF38A	Physical association	Medium	0.53	19
IK	Physical association	Medium	0.51	21
PRPF3	Physical association	Medium	0.51	35
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
MFAP1 is not a metabolic protein