Protein interactions for FXR2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FXR2
Gene descriptionⁱ Full gene name according to HGNC.	FMR1 autosomal homolog 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Skeletal muscle - Muscle contraction (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enhanced (skeletal muscle)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.34
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Cytosol
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Skeletal muscle - Muscle contraction

Field

Cluster

Pathway

Number of interactions:

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
PCBD1	Physical association	High	0.8	12
AP1M1	Physical association	High	0.78	67
CDKL3	Physical association	High	0.78	22
LCP2	Physical association	High	0.78	16
PRAM1	Physical association	High	0.78	17
TBC1D22B	Physical association	High	0.74	46
BYSL	Physical association	High	0.72	119
C1orf35	Physical association	High	0.72	32
MFAP1	Physical association	High	0.72	79
SYTL4	Physical association	High	0.72	19
YES1	Physical association	High	0.72	44
ZMAT2	Physical association	High	0.72	44
NME1	Physical association	High	0.71	15
PAICS	Physical association	High	0.71	9
CBS	Physical association	High	0.67	17
FTH1	Physical association	High	0.67	8
SRPK2	Physical association	High	0.67	46
UBAP2L	Physical association	High	0.67	4
C10orf62	Physical association	High	0.67	9
MCRS1	Physical association	High	0.67	97
PAF1	Physical association	High	0.67	10
POM121	Physical association	High	0.67	7
SCEL	Physical association	High	0.67	6
FMR1	Physical association	High	0.66	13
FXR1	Physical association	High	0.66	18
ARL6IP1	Physical association	High	0.62	60
LDOC1	Physical association	High	0.62	82
MBIP	Physical association	High	0.62	9
MEAF6	Physical association	High	0.62	10
NT5C2	Physical association	High	0.62	9
PTS	Physical association	High	0.62	8
RABAC1	Physical association	High	0.62	48
BAZ2B	Physical association	Medium	0.56	9
BLK	Physical association	Medium	0.56	22
CAMK2D	Physical association	Medium	0.56	13
CEP44	Physical association	Medium	0.56	40
CEP55	Physical association	Medium	0.56	56
CWF19L2	Physical association	Medium	0.56	65
FAM90A1	Physical association	Medium	0.56	128
HMBOX1	Physical association	Medium	0.56	76
INPP5J	Physical association	Medium	0.56	15
LASP1	Physical association	Medium	0.56	21
MORF4L1	Physical association	Medium	0.56	28
MRPL43	Physical association	Medium	0.56	1
NIF3L1	Physical association	Medium	0.56	52
OPTN	Physical association	Medium	0.56	127
PIM1	Physical association	Medium	0.56	7
ZBTB22	Physical association	Medium	0.56	10
ZNF232	Physical association	Medium	0.56	21
AP2M1	Physical association	Medium	0.55	38
EWSR1	Physical association	Medium	0.55	23
FBP1	Physical association	Medium	0.55	6
PSME3	Physical association	Medium	0.55	35
RALYL	Physical association	Medium	0.55	6
TRAF2	Physical association	Medium	0.55	237
LCMT1	Physical association	Medium	0.51	1
DDX6	Physical association	Medium	0.5	66
TRIM23	Physical association	Medium	0.49	142
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
FXR2 is not a metabolic protein