Protein interactions for TRIM23 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TRIM23
Gene descriptionⁱ Full gene name according to HGNC.	Tripartite motif containing 23
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Unknown function (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.36
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Not available
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Unknown function

Field

Cluster

Pathway

Number of interactions:

142

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
TBC1D22B	Physical association	High	0.83	46
ZNF581	Physical association	High	0.83	82
GEM	Physical association	High	0.82	88
ATPAF2	Physical association	High	0.78	57
GPANK1	Physical association	High	0.78	65
IQUB	Physical association	High	0.78	56
SNAI1	Physical association	High	0.78	29
ARHGEF3	Physical association	High	0.74	7
COX5B	Physical association	High	0.74	29
AQP1	Physical association	High	0.72	106
CDR2	Physical association	High	0.72	68
FAM110A	Physical association	High	0.72	41
FAM133A	Physical association	High	0.72	17
FAM90A1	Physical association	High	0.72	128
HOXB5	Physical association	High	0.72	47
KLHL42	Physical association	High	0.72	24
KRT6A	Physical association	High	0.72	30
MORN4	Physical association	High	0.72	23
RAMAC	Physical association	High	0.72	37
SMG9	Physical association	High	0.72	32
SORBS3	Physical association	High	0.72	87
TNFAIP3	Physical association	High	0.72	14
UBQLN1	Physical association	High	0.72	213
ZNF564	Physical association	High	0.72	30
BAG1	Physical association	High	0.7	8
PSMA1	Physical association	High	0.7	135
TROAP	Physical association	High	0.7	14
LNX1	Physical association	High	0.67	333
BRME1	Physical association	High	0.67	19
CARD9	Physical association	High	0.67	52
GATA2	Physical association	High	0.67	24
GPKOW	Physical association	High	0.67	40
LGALS8	Physical association	High	0.67	6
NEK6	Physical association	High	0.67	20
PHF1	Physical association	High	0.67	45
PITX1	Physical association	High	0.67	50
TRIM29	Physical association	High	0.67	13
TRIM55	Physical association	Medium	0.57	2
ANKRD55	Physical association	Medium	0.56	17
AP3M1	Physical association	Medium	0.56	10
ARFGAP1	Physical association	Medium	0.56	7
ATXN1	Physical association	Medium	0.56	271
BICRAL	Physical association	Medium	0.56	13
C2CD6	Physical association	Medium	0.56	44
C8orf33	Physical association	Medium	0.56	20
CASP6	Physical association	Medium	0.56	122
CBX8	Physical association	Medium	0.56	78
CCDC13	Physical association	Medium	0.56	37
CCDC25	Physical association	Medium	0.56	2
CDC20B	Physical association	Medium	0.56	11
CDC73	Physical association	Medium	0.56	30
CFAP53	Physical association	Medium	0.56	23
CSRP2	Physical association	Medium	0.56	4
CWF19L2	Physical association	Medium	0.56	65
CXCL14	Physical association	Medium	0.56	5
DCX	Physical association	Medium	0.56	13
DMC1	Physical association	Medium	0.56	10
DMRT3	Physical association	Medium	0.56	65
DOCK2	Physical association	Medium	0.56	36
EAF2	Physical association	Medium	0.56	13
EHHADH	Physical association	Medium	0.56	94
EIF3D	Physical association	Medium	0.56	27
ENKD1	Physical association	Medium	0.56	159
FAM83A	Physical association	Medium	0.56	22
FGFR3	Physical association	Medium	0.56	192
GMCL2	Physical association	Medium	0.56	22
GRIN2C	Physical association	Medium	0.56	58
GSN	Physical association	Medium	0.56	126
HAPLN2	Physical association	Medium	0.56	36
HAUS1	Physical association	Medium	0.56	83
HGS	Physical association	Medium	0.56	177
HIP1	Physical association	Medium	0.56	48
HRAS	Physical association	Medium	0.56	87
HSPB1	Physical association	Medium	0.56	137
HSPB7	Physical association	Medium	0.56	15
JOSD1	Physical association	Medium	0.56	24
KAT5	Physical association	Medium	0.56	180
KIFC3	Physical association	Medium	0.56	70
KRT75	Physical association	Medium	0.56	103
KRT76	Physical association	Medium	0.56	33
LAGE3	Physical association	Medium	0.56	19
LENG1	Physical association	Medium	0.56	63
LGALS14	Physical association	Medium	0.56	43
LMO2	Physical association	Medium	0.56	61
MRPL4	Physical association	Medium	0.56	3
MTFR2	Physical association	Medium	0.56	6
MYOZ1	Physical association	Medium	0.56	28
NAB2	Physical association	Medium	0.56	62
NFU1	Physical association	Medium	0.56	15
NTAQ1	Physical association	Medium	0.56	302
NUDT21	Physical association	Medium	0.56	20
NXT2	Physical association	Medium	0.56	10
PIAS2	Physical association	Medium	0.56	16
PIK3R2	Physical association	Medium	0.56	21
PKP4	Physical association	Medium	0.56	8
PPIL2	Physical association	Medium	0.56	2
PPP1R15B	Physical association	Medium	0.56	3
PPP1R18	Physical association	Medium	0.56	68
PRPF18	Physical association	Medium	0.56	63
PRPF31	Physical association	Medium	0.56	118
PSMB1	Physical association	Medium	0.56	83
RAN	Physical association	Medium	0.56	86
RCAN3	Physical association	Medium	0.56	4
RIBC1	Physical association	Medium	0.56	21
RIN1	Physical association	Medium	0.56	38
RTP5	Physical association	Medium	0.56	49
SCNM1	Physical association	Medium	0.56	148
SH2D4A	Physical association	Medium	0.56	63
SIAH1	Physical association	Medium	0.56	88
SLC25A6	Physical association	Medium	0.56	12
SNAI2	Physical association	Medium	0.56	5
SNRPB2	Physical association	Medium	0.56	16
SNW1	Physical association	Medium	0.56	89
SPG21	Physical association	Medium	0.56	129
TACO1	Physical association	Medium	0.56	15
TARDBP	Physical association	Medium	0.56	141
TCEA2	Physical association	Medium	0.56	88
TEPSIN	Physical association	Medium	0.56	101
TRAF1	Physical association	Medium	0.56	166
TRIM42	Physical association	Medium	0.56	112
TSEN54	Physical association	Medium	0.56	14
TSHZ3	Physical association	Medium	0.56	24
USP2	Physical association	Medium	0.56	78
USP20	Physical association	Medium	0.56	10
UTP23	Physical association	Medium	0.56	22
VGLL1	Physical association	Medium	0.56	11
WDR25	Physical association	Medium	0.56	5
WFS1	Physical association	Medium	0.56	315
ZBTB16	Physical association	Medium	0.56	43
ZBTB4	Physical association	Medium	0.56	9
ZC2HC1C	Physical association	Medium	0.56	18
ZFAND2A	Physical association	Medium	0.56	5
ZNF20	Physical association	Medium	0.56	43
ZNF408	Physical association	Medium	0.56	51
ZNF417	Physical association	Medium	0.56	140
ZNF474	Physical association	Medium	0.56	18
ZNF587	Physical association	Medium	0.56	102
ZNF835	Physical association	Medium	0.56	54
FLAD1	Physical association	Medium	0.55	6
DEPP1	Physical association	Medium	0.49	1
FXR2	Physical association	Medium	0.49	58
POLI	Physical association	Medium	0.49	13
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
TRIM23 is not a metabolic protein