Protein interactions for CASP6 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CASP6
Gene descriptionⁱ Full gene name according to HGNC.	Caspase 6
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Intestine - Digestion (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enhanced (intestine)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.45
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Cytosol In addition localized to the Nucleoplasm
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Intestine - Digestion

Field

Cluster

Pathway

Number of interactions:

122

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
CASP3	Direct interaction	Medium	0.57	16
ACTL7B	Physical association	Medium	0.56	3
AK8	Physical association	Medium	0.56	20
AKR1C8	Physical association	Medium	0.56	3
ANKEF1	Physical association	Medium	0.56	6
ANXA4	Physical association	Medium	0.56	8
APOA4	Physical association	Medium	0.56	4
APOBEC4	Physical association	Medium	0.56	2
ASCL4	Physical association	Medium	0.56	34
ATF4	Physical association	Medium	0.56	34
ATG10	Physical association	Medium	0.56	10
BAAT	Physical association	Medium	0.56	9
BCHE	Physical association	Medium	0.56	5
C10orf88	Physical association	Medium	0.56	9
C12orf4	Physical association	Medium	0.56	3
C1D	Physical association	Medium	0.56	11
C4orf33	Physical association	Medium	0.56	4
CAPN2	Physical association	Medium	0.56	8
CCNC	Physical association	Medium	0.56	69
CDC23	Physical association	Medium	0.56	69
CDKN2C	Physical association	Medium	0.56	19
CDS2	Physical association	Medium	0.56	29
CHMP7	Physical association	Medium	0.56	15
CIAO2B	Physical association	Medium	0.56	19
CIART	Physical association	Medium	0.56	2
CITED1	Physical association	Medium	0.56	4
COA7	Physical association	Medium	0.56	11
CRCT1	Physical association	Medium	0.56	46
CRYBB3	Physical association	Medium	0.56	5
CTNNB1	Physical association	Medium	0.56	81
CYBRD1	Physical association	Medium	0.56	19
DCAF7	Physical association	Medium	0.56	42
DLX3	Physical association	Medium	0.56	7
DPYSL5	Physical association	Medium	0.56	16
E2F8	Physical association	Medium	0.56	16
EIF3F	Physical association	Medium	0.56	42
EIF3I	Physical association	Medium	0.56	8
ELL2	Physical association	Medium	0.56	16
EML1	Physical association	Medium	0.56	4
FAM9A	Physical association	Medium	0.56	47
FGD5	Physical association	Medium	0.56	4
FGF21	Physical association	Medium	0.56	6
GNB4	Physical association	Medium	0.56	2
H3-5	Physical association	Medium	0.56	17
HAUS8	Physical association	Medium	0.56	18
HTT	Physical association	Medium	0.56	665
JADE3	Physical association	Medium	0.56	7
JMJD7	Physical association	Medium	0.56	14
JPT1	Physical association	Medium	0.56	5
KCTD17	Physical association	Medium	0.56	29
KLHL3	Physical association	Medium	0.56	9
KRT222	Physical association	Medium	0.56	9
LGALS9C	Physical association	Medium	0.56	23
LHX5	Physical association	Medium	0.56	17
LIPT1	Physical association	Medium	0.56	4
LNX1	Physical association	Medium	0.56	333
LONRF2	Physical association	Medium	0.56	12
LOXL4	Physical association	Medium	0.56	15
LRRC56	Physical association	Medium	0.56	6
MAL2	Physical association	Medium	0.56	37
MAOB	Physical association	Medium	0.56	14
MRI1	Physical association	Medium	0.56	7
MYBPHL	Physical association	Medium	0.56	10
MYC	Physical association	Medium	0.56	88
NAA60	Physical association	Medium	0.56	2
NTAQ1	Physical association	Medium	0.56	302
NUP37	Physical association	Medium	0.56	4
NUP43	Physical association	Medium	0.56	11
NUP54	Physical association	Medium	0.56	40
ODF3L2	Physical association	Medium	0.56	10
PCYT2	Physical association	Medium	0.56	4
PER1	Physical association	Medium	0.56	21
PHF23	Physical association	Medium	0.56	7
PITPNA	Physical association	Medium	0.56	3
PITPNB	Physical association	Medium	0.56	2
PKIA	Physical association	Medium	0.56	7
PLIN3	Physical association	Medium	0.56	22
POLA2	Physical association	Medium	0.56	6
POLR1D	Physical association	Medium	0.56	6
POLR2I	Physical association	Medium	0.56	4
PPARA	Physical association	Medium	0.56	18
PPP1R11	Physical association	Medium	0.56	9
PRKAG1	Physical association	Medium	0.56	21
PTGDS	Physical association	Medium	0.56	10
PTPN4	Physical association	Medium	0.56	4
RBBP4	Physical association	Medium	0.56	36
RELA	Physical association	Medium	0.56	54
RHEB	Physical association	Medium	0.56	10
RING1	Physical association	Medium	0.56	23
RNF10	Physical association	Medium	0.56	13
RPS4X	Physical association	Medium	0.56	13
SCAMP1	Physical association	Medium	0.56	13
SERPINA3	Physical association	Medium	0.56	6
SF3B3	Physical association	Medium	0.56	9
SH3GLB2	Physical association	Medium	0.56	19
SHCBP1L	Physical association	Medium	0.56	4
SMG6	Physical association	Medium	0.56	3
SNCA	Physical association	Medium	0.56	124
SNF8	Physical association	Medium	0.56	19
SNW1	Physical association	Medium	0.56	89
SPATA12	Physical association	Medium	0.56	22
SPATS1	Physical association	Medium	0.56	17
SPRY4	Physical association	Medium	0.56	30
SPSB1	Physical association	Medium	0.56	19
TCAP	Physical association	Medium	0.56	34
TEN1	Physical association	Medium	0.56	14
TENT5B	Physical association	Medium	0.56	57
TGM1	Physical association	Medium	0.56	24
TGM5	Physical association	Medium	0.56	6
TIGAR	Physical association	Medium	0.56	4
TP53	Physical association	Medium	0.56	157
TP53BP1	Physical association	Medium	0.56	71
TRIM23	Physical association	Medium	0.56	142
TUBB2A	Physical association	Medium	0.56	9
UBE2A	Physical association	Medium	0.56	17
WBP1L	Physical association	Medium	0.56	15
WDR77	Physical association	Medium	0.56	6
WNT7A	Physical association	Medium	0.56	5
YIF1A	Physical association	Medium	0.56	66
ZBTB14	Physical association	Medium	0.56	54
ZNF597	Physical association	Medium	0.56	8
ZNG1C	Physical association	Medium	0.56	6
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
CASP6 is not a metabolic protein