Protein interactions for TP53 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TP53
Gene descriptionⁱ Full gene name according to HGNC.	Tumor protein p53
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes Disease related genes Human disease related genes Plasma proteins Potential drug targets Transcription factors Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	23

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Lymphoid tissue - Cytokine signaling (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.26
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nucleoplasm In addition localized to the Vesicles, Cytosol
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

Highlight:

Off

Subcell location

Predicted location

Tissue specificity

Protein class

Filter menu »

e.g. Brain enriched, Localized to mitochondria, Lymphoid tissue - Cytokine signaling

Field

Cluster

Pathway

Number of interactions:

157

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
MDM2	Direct interaction	High	0.99	60
EP300	Direct interaction	High	0.98	34
USP7	Direct interaction	High	0.97	34
MDM4	Direct interaction	High	0.96	22
UBC	Physical association	High	0.96	56
CREBBP	Direct interaction	High	0.96	36
SIRT1	Direct interaction	High	0.96	44
SETD7	Direct interaction	High	0.92	17
TP53BP2	Direct interaction	High	0.9	14
RCHY1	Direct interaction	High	0.89	17
CUL9	Physical association	High	0.85	1
S100A4	Direct interaction	High	0.85	13
PIN1	Physical association	High	0.85	112
DAXX	Direct interaction	High	0.84	78
CUL7	Physical association	High	0.83	1
TP53BP1	Direct interaction	High	0.83	71
TWIST1	Direct interaction	High	0.82	22
PPP1R13L	Direct interaction	High	0.81	6
HSPA9	Direct interaction	High	0.81	10
SMYD2	Direct interaction	High	0.81	6
DVL2	Physical association	High	0.78	43
UBE3A	Direct interaction	High	0.77	7
VRK1	Direct interaction	High	0.76	12
PTK2	Direct interaction	High	0.75	24
PARP1	Direct interaction	High	0.75	22
HMGB1	Direct interaction	High	0.74	20
UBE2I	Direct interaction	High	0.74	40
PLK1	Direct interaction	High	0.74	50
MAGEA2	Direct interaction	High	0.73	25
MAGEA2B	Direct interaction	High	0.73	25
BRD7	Physical association	High	0.73	14
BHLHE40	Physical association	High	0.73	52
SUMO1	Direct interaction	High	0.72	59
GTF2H1	Direct interaction	High	0.72	13
COP1	Direct interaction	High	0.72	6
PBK	Physical association	High	0.71	5
TPT1	Physical association	High	0.71	14
HIPK2	Direct interaction	High	0.71	8
HDAC1	Physical association	High	0.71	63
CDKN1A	Physical association	High	0.71	49
HTT	Physical association	High	0.71	665
PML	Physical association	High	0.7	14
HNRNPUL1	Direct interaction	High	0.7	17
ARIH2	Direct interaction	High	0.69	11
DROSHA	Physical association	High	0.68	7
NPM1	Direct interaction	High	0.68	22
S100A2	Direct interaction	High	0.68	13
S100A6	Direct interaction	High	0.68	11
SMAD2	Physical association	High	0.67	19
MAGEB18	Physical association	High	0.67	10
SFN	Direct interaction	High	0.67	39
STIP1	Physical association	High	0.67	19
HSPB1	Physical association	High	0.66	137
CCT5	Physical association	High	0.66	28
GSK3B	Direct interaction	High	0.66	28
DDX5	Physical association	High	0.66	16
BRCA2	Direct interaction	High	0.65	11
RING1	Direct interaction	High	0.65	23
PPP2R5C	Physical association	High	0.65	6
WRN	Direct interaction	High	0.65	15
CHEK2	Direct interaction	High	0.65	18
DUSP26	Direct interaction	High	0.65	6
FBXO11	Direct interaction	High	0.65	6
NCOR2	Direct interaction	High	0.65	13
RBPJ	Direct interaction	High	0.65	12
PIK3R3	Direct interaction	High	0.64	70
JMJD6	Direct interaction	High	0.64	10
PPIF	Direct interaction	High	0.64	13
NUMB	Direct interaction	High	0.63	10
NOC2L	Direct interaction	High	0.63	2
OTUB1	Direct interaction	High	0.63	43
PPP2R1A	Physical association	High	0.63	35
S100A1	Direct interaction	High	0.62	15
S100B	Direct interaction	High	0.62	32
RFWD3	Direct interaction	High	0.62	8
RYBP	Physical association	High	0.62	44
PHB1	Physical association	High	0.62	6
RUVBL1	Physical association	High	0.62	16
SYVN1	Physical association	High	0.61	8
IKBKB	Direct interaction	High	0.61	20
CCDC106	Physical association	High	0.61	15
ETS2	Direct interaction	High	0.6	9
IP6K2	Direct interaction	High	0.6	7
MKRN1	Direct interaction	High	0.6	14
PRKCD	Direct interaction	High	0.6	9
CXXC1	Physical association	Medium	0.6	5
AIMP2	Direct interaction	Medium	0.59	33
MAGEC2	Direct interaction	Medium	0.59	11
NUAK1	Direct interaction	Medium	0.59	4
ZNF420	Direct interaction	Medium	0.59	7
SOX4	Physical association	Medium	0.59	1
SRPK1	Physical association	Medium	0.59	25
RPS3	Direct interaction	Medium	0.59	14
HNRNPK	Physical association	Medium	0.59	49
SIN3A	Physical association	Medium	0.59	11
SP1	Physical association	Medium	0.59	24
TP63	Physical association	Medium	0.59	13
XPO1	Physical association	Medium	0.59	6
NR4A1	Physical association	Medium	0.58	15
TOE1	Direct interaction	Medium	0.58	2
NRDC	Physical association	Medium	0.58	1
PSME3	Physical association	Medium	0.58	35
CSNK2A1	Direct interaction	Medium	0.57	54
PIAS1	Direct interaction	Medium	0.57	38
BCL2	Physical association	Medium	0.56	25
KAT8	Physical association	Medium	0.56	3
NFYB	Physical association	Medium	0.56	8
TCF4	Physical association	Medium	0.56	124
YWHAZ	Physical association	Medium	0.56	128
NCL	Direct interaction	Medium	0.56	13
CASP6	Physical association	Medium	0.56	122
PEX26	Physical association	Medium	0.56	28
UCHL1	Physical association	Medium	0.56	29
CEBPB	Physical association	Medium	0.56	5
MAP1B	Physical association	Medium	0.56	3
SAFB	Physical association	Medium	0.56	4
HINFP	Physical association	Medium	0.55	3
TK1	Physical association	Medium	0.55	16
S100A11	Direct interaction	Medium	0.54	4
S100A5	Direct interaction	Medium	0.54	7
S100P	Direct interaction	Medium	0.54	15
BRCA1	Direct interaction	Medium	0.54	38
CSE1L	Direct interaction	Medium	0.54	8
MT1A	Direct interaction	Medium	0.54	2
NOL3	Direct interaction	Medium	0.54	5
NFYA	Physical association	Medium	0.54	9
VDR	Physical association	Medium	0.54	11
FOXO3	Physical association	Medium	0.54	17
HSPA1L	Physical association	Medium	0.54	9
AXIN1	Physical association	Medium	0.52	40
CEBPZ	Physical association	Medium	0.52	2
DDX17	Physical association	Medium	0.52	20
HUWE1	Physical association	Medium	0.52	6
KMT2E	Physical association	Medium	0.52	1
MED1	Physical association	Medium	0.52	16
NR0B2	Physical association	Medium	0.52	8
SNAI1	Physical association	Medium	0.52	29
SREBF2	Physical association	Medium	0.52	5
TRIM24	Physical association	Medium	0.52	2
UHRF2	Physical association	Medium	0.52	6
BCR	Physical association	Medium	0.52	4
LAMA4	Physical association	Medium	0.52	1
PIAS2	Physical association	Medium	0.52	16
BTBD2	Physical association	Medium	0.51	12
FXR1	Physical association	Medium	0.51	18
HIPK1	Physical association	Medium	0.51	2
PIAS4	Physical association	Medium	0.51	35
AIPL1	Physical association	Medium	0.51	17
ARRB1	Physical association	Medium	0.5	33
BANP	Physical association	Medium	0.5	58
KAT5	Physical association	Medium	0.5	180
MPDZ	Physical association	Medium	0.5	6
PARD3	Physical association	Medium	0.5	15
IFI16	Physical association	Medium	0.49	4
EAF2	Physical association	Medium	0.49	13
PLCG2	Physical association	Medium	0.49	11
PRKAB2	Physical association	Medium	0.49	126
Show allShow less

METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
TP53 is not a metabolic protein