Protein interactions for DCAF7 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DCAF7
Gene descriptionⁱ Full gene name according to HGNC.	DDB1 and CUL4 associated factor 7
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Transcription (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.17
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nucleoplasm In addition localized to the Cytosol
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Transcription

Field

Cluster

Pathway

Number of interactions:

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
DYRK1A	Direct interaction	High	0.91	12
DYRK1B	Direct interaction	High	0.81	10
MAP3K1	Direct interaction	High	0.71	7
HTT	Physical association	High	0.67	665
HIPK2	Direct interaction	High	0.64	8
FOXK1	Physical association	High	0.64	4
PARD3	Physical association	High	0.64	15
PLK1	Physical association	High	0.64	50
CASP6	Physical association	Medium	0.56	122
KLK6	Physical association	Medium	0.56	100
TARDBP	Physical association	Medium	0.56	141
AMBRA1	Physical association	Medium	0.51	7
ANKS6	Physical association	Medium	0.51	23
CAMSAP3	Physical association	Medium	0.51	2
CDK17	Physical association	Medium	0.51	6
CEP170	Physical association	Medium	0.51	12
CLASP2	Physical association	Medium	0.51	3
CRTC3	Physical association	Medium	0.51	4
DDA1	Physical association	Medium	0.51	8
DOCK7	Physical association	Medium	0.51	5
DYNLL1	Physical association	Medium	0.51	59
DYNLL2	Physical association	Medium	0.51	50
ENAH	Physical association	Medium	0.51	3
EPS15L1	Physical association	Medium	0.51	6
FAM117B	Physical association	Medium	0.51	21
GLCCI1	Physical association	Medium	0.51	1
GPBP1L1	Physical association	Medium	0.51	5
KIAA1671	Physical association	Medium	0.51	2
LRCH2	Physical association	Medium	0.51	3
LRCH3	Physical association	Medium	0.51	1
NET1	Physical association	Medium	0.51	4
NUMB	Physical association	Medium	0.51	10
PCARE	Physical association	Medium	0.51	5
PPFIBP1	Physical association	Medium	0.51	5
PPP1CA	Physical association	Medium	0.51	87
PPP1CB	Physical association	Medium	0.51	42
PRKCI	Physical association	Medium	0.51	14
PTPDC1	Physical association	Medium	0.51	4
SKP1	Physical association	Medium	0.51	51
TXNDC5	Physical association	Medium	0.51	2
XRN2	Physical association	Medium	0.51	9
YWHAE	Physical association	Medium	0.51	42
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
DCAF7 is not a metabolic protein