Protein interactions for TARDBP - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TARDBP
Gene descriptionⁱ Full gene name according to HGNC.	TAR DNA binding protein
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	14

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Basic cellular processes (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.09
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nucleoplasm
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Basic cellular processes

Field

Cluster

Pathway

Number of interactions:

141

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
FUS	Physical association	High	0.68	23
GNB2	Physical association	High	0.67	26
HNRNPH1	Physical association	High	0.67	30
OTUB1	Physical association	High	0.67	43
TOB1	Physical association	High	0.67	10
NSFL1C	Physical association	High	0.67	2
XRN2	Physical association	High	0.67	9
ELAVL1	Physical association	High	0.61	3
ZNF366	Physical association	High	0.61	22
PPP1R15A	Physical association	Medium	0.6	5
ABTB1	Physical association	Medium	0.56	4
ADAR	Physical association	Medium	0.56	2
ANXA8	Physical association	Medium	0.56	14
APP	Physical association	Medium	0.56	312
ASB13	Physical association	Medium	0.56	10
ASB9	Physical association	Medium	0.56	15
ATF3	Physical association	Medium	0.56	17
ATP6V1B1	Physical association	Medium	0.56	8
BAHD1	Physical association	Medium	0.56	54
BEX5	Physical association	Medium	0.56	16
BIRC5	Physical association	Medium	0.56	22
BTBD1	Physical association	Medium	0.56	10
C6orf141	Physical association	Medium	0.56	8
C8orf48	Physical association	Medium	0.56	17
CBLB	Physical association	Medium	0.56	25
CBLC	Physical association	Medium	0.56	6
CCIN	Physical association	Medium	0.56	2
CDC16	Physical association	Medium	0.56	9
CDC23	Physical association	Medium	0.56	69
CLPP	Physical association	Medium	0.56	19
CRLF3	Physical association	Medium	0.56	24
DCAF7	Physical association	Medium	0.56	42
DDX17	Physical association	Medium	0.56	20
DDX3X	Physical association	Medium	0.56	12
DDX5	Physical association	Medium	0.56	16
DEAF1	Physical association	Medium	0.56	9
EIF3F	Physical association	Medium	0.56	42
ENKUR	Physical association	Medium	0.56	9
ESRP1	Physical association	Medium	0.56	28
EXOC5	Physical association	Medium	0.56	46
FAM117B	Physical association	Medium	0.56	21
FAM98C	Physical association	Medium	0.56	9
FAM9A	Physical association	Medium	0.56	47
FBXL5	Physical association	Medium	0.56	2
FBXO4	Physical association	Medium	0.56	6
GMPPA	Physical association	Medium	0.56	10
GPSM3	Physical association	Medium	0.56	38
GTPBP3	Physical association	Medium	0.56	18
HDAC6	Physical association	Medium	0.56	19
HES4	Physical association	Medium	0.56	6
HNRNPC	Physical association	Medium	0.56	25
HNRNPDL	Physical association	Medium	0.56	3
HNRNPK	Physical association	Medium	0.56	49
HNRNPUL1	Physical association	Medium	0.56	17
ID2	Physical association	Medium	0.56	20
IGF2BP2	Physical association	Medium	0.56	2
IGF2BP3	Physical association	Medium	0.56	2
JADE3	Physical association	Medium	0.56	7
KCTD17	Physical association	Medium	0.56	29
KLF15	Physical association	Medium	0.56	30
KLHL17	Physical association	Medium	0.56	2
KLHL20	Physical association	Medium	0.56	31
KLHL22	Physical association	Medium	0.56	5
KLHL26	Physical association	Medium	0.56	12
KLHL32	Physical association	Medium	0.56	4
KRTAP9-2	Physical association	Medium	0.56	123
LDHAL6B	Physical association	Medium	0.56	17
LGALS9C	Physical association	Medium	0.56	23
LNX1	Physical association	Medium	0.56	333
LNX2	Physical association	Medium	0.56	63
LONRF2	Physical association	Medium	0.56	12
LSM8	Physical association	Medium	0.56	12
MAPK11	Physical association	Medium	0.56	14
MATR3	Physical association	Medium	0.56	14
METTL27	Physical association	Medium	0.56	41
MGARP	Physical association	Medium	0.56	14
MKRN2	Physical association	Medium	0.56	9
MKRN3	Physical association	Medium	0.56	118
MLC1	Physical association	Medium	0.56	13
MNAT1	Physical association	Medium	0.56	5
MOCS3	Physical association	Medium	0.56	3
MPND	Physical association	Medium	0.56	15
MYC	Physical association	Medium	0.56	88
NME4	Physical association	Medium	0.56	43
NUP43	Physical association	Medium	0.56	11
OTX1	Physical association	Medium	0.56	118
PACS1	Physical association	Medium	0.56	8
PBX4	Physical association	Medium	0.56	60
PCMTD2	Physical association	Medium	0.56	8
PRPF8	Physical association	Medium	0.56	19
PRPS1	Physical association	Medium	0.56	79
PSMB4	Physical association	Medium	0.56	31
PSMD2	Physical association	Medium	0.56	25
RAD18	Physical association	Medium	0.56	12
RBBP4	Physical association	Medium	0.56	36
RBCK1	Physical association	Medium	0.56	21
RBM10	Physical association	Medium	0.56	35
RBM46	Physical association	Medium	0.56	7
RBMX	Physical association	Medium	0.56	28
RMND5A	Physical association	Medium	0.56	18
RMND5B	Physical association	Medium	0.56	13
RNF10	Physical association	Medium	0.56	13
RNF112	Physical association	Medium	0.56	18
RNF138	Physical association	Medium	0.56	18
RNF14	Physical association	Medium	0.56	6
RNF166	Physical association	Medium	0.56	4
RNF183	Physical association	Medium	0.56	30
RYBP	Physical association	Medium	0.56	44
SF3B3	Physical association	Medium	0.56	9
SKIC8	Physical association	Medium	0.56	30
SLC44A5	Physical association	Medium	0.56	8
SMARCD1	Physical association	Medium	0.56	104
SOCS6	Physical association	Medium	0.56	13
SPATA22	Physical association	Medium	0.56	16
SPSB1	Physical association	Medium	0.56	19
STAMBP	Physical association	Medium	0.56	21
TASOR2	Physical association	Medium	0.56	34
TBX22	Physical association	Medium	0.56	10
THAP3	Physical association	Medium	0.56	15
TRIM23	Physical association	Medium	0.56	142
TRIM8	Physical association	Medium	0.56	17
TRIM9	Physical association	Medium	0.56	18
UBA7	Physical association	Medium	0.56	2
UBE2V1	Physical association	Medium	0.56	23
UBOX5	Physical association	Medium	0.56	4
UBQLNL	Physical association	Medium	0.56	8
USP13	Physical association	Medium	0.56	7
USP48	Physical association	Medium	0.56	1
VPS37A	Physical association	Medium	0.56	18
VSX2	Physical association	Medium	0.56	20
WDR12	Physical association	Medium	0.56	2
WDR83	Physical association	Medium	0.56	30
WWP2	Physical association	Medium	0.56	51
YBX1	Physical association	Medium	0.56	27
ZBTB25	Physical association	Medium	0.56	24
ZNF581	Physical association	Medium	0.56	82
ATXN2	Physical association	Medium	0.52	10
IRAK2	Physical association	Medium	0.5	10
KPNA4	Physical association	Medium	0.5	21
IQSEC1	Physical association	Medium	0.47	4
RELA	Physical association	Medium	0.46	54
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
TARDBP is not a metabolic protein