Protein interactions for LNX1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	LNX1
Gene descriptionⁱ Full gene name according to HGNC.	Ligand of numb-protein X 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Epithelium - Extracellular exosomes (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.40
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Cell Junctions In addition localized to the Cytosol
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Epithelium - Extracellular exosomes

Field

Cluster

Pathway

Number of interactions:

333

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
MAGEB18	Physical association	High	0.89	10
AIMP2	Physical association	High	0.83	33
APIP	Physical association	High	0.83	16
CLK2	Physical association	High	0.83	45
SAT1	Physical association	High	0.83	40
TRIP13	Physical association	High	0.83	71
ATPAF2	Physical association	High	0.81	57
CDA	Physical association	High	0.81	14
CEP72	Physical association	High	0.8	19
DNPEP	Physical association	High	0.78	2
HSBP1	Physical association	High	0.78	15
KCTD1	Physical association	High	0.78	16
KRTAP4-2	Physical association	High	0.78	102
MAPK9	Physical association	High	0.78	48
MRFAP1L1	Physical association	High	0.78	46
NME7	Physical association	High	0.78	62
PCBD1	Physical association	High	0.78	12
SSNA1	Physical association	High	0.78	12
TRIM54	Physical association	High	0.78	151
TSSK3	Physical association	High	0.78	51
PAFAH1B3	Physical association	High	0.77	7
BLVRA	Physical association	High	0.74	2
DAB1	Physical association	High	0.74	36
KCTD13	Physical association	High	0.74	22
KRT15	Physical association	High	0.74	100
MTMR9	Physical association	High	0.74	16
NADK	Physical association	High	0.74	6
ROPN1	Physical association	High	0.74	37
RPIA	Physical association	High	0.74	15
TRAF2	Physical association	High	0.74	237
ZBTB43	Physical association	High	0.74	21
ALDOC	Physical association	High	0.72	3
CA8	Physical association	High	0.72	11
GDI1	Physical association	High	0.72	4
MEMO1	Physical association	High	0.72	16
NUDT14	Physical association	High	0.72	8
OSGIN1	Physical association	High	0.72	30
PRPH	Physical association	High	0.72	57
RAD51D	Physical association	High	0.72	35
RUFY4	Physical association	High	0.72	9
RUVBL2	Physical association	High	0.72	10
ZNF581	Physical association	High	0.72	82
PNMA1	Physical association	High	0.7	114
TRAF1	Physical association	High	0.7	166
TRIM23	Physical association	High	0.67	142
CCDC102B	Physical association	High	0.67	87
DDX17	Physical association	High	0.67	20
EIF4H	Physical association	High	0.67	3
ENOX1	Physical association	High	0.67	5
FAM118A	Physical association	High	0.67	12
GRB2	Physical association	High	0.67	165
KCTD6	Physical association	High	0.67	20
KLHL12	Physical association	High	0.67	40
KXD1	Physical association	High	0.67	27
METTL21A	Physical association	High	0.67	10
MTUS2	Physical association	High	0.67	130
NOTCH2NLA	Physical association	High	0.67	190
PAICS	Physical association	High	0.67	9
POMGNT1	Physical association	High	0.67	6
PRR13	Physical association	High	0.67	37
RAD54B	Physical association	High	0.67	3
RBMX	Physical association	High	0.67	28
RBMY1A1	Physical association	High	0.67	14
VCP	Physical association	High	0.67	48
ZFP64	Physical association	High	0.67	14
NAGK	Physical association	High	0.63	8
A2M	Physical association	Medium	0.56	51
ACAT2	Physical association	Medium	0.56	3
ACTN1	Physical association	Medium	0.56	26
ACTN3	Physical association	Medium	0.56	38
ACTN4	Physical association	Medium	0.56	14
ACY3	Physical association	Medium	0.56	15
AGTRAP	Physical association	Medium	0.56	59
AIDA	Physical association	Medium	0.56	6
ALKBH3	Physical association	Medium	0.56	5
AP1M1	Physical association	Medium	0.56	67
ARF3	Physical association	Medium	0.56	2
ARFIP2	Physical association	Medium	0.56	42
ATRIP	Physical association	Medium	0.56	15
ATXN1	Physical association	Medium	0.56	271
AXIN2	Physical association	Medium	0.56	36
BIRC2	Physical association	Medium	0.56	30
BLZF1	Physical association	Medium	0.56	84
BORCS6	Physical association	Medium	0.56	30
BTBD1	Physical association	Medium	0.56	10
C10orf88	Physical association	Medium	0.56	9
C1QTNF1	Physical association	Medium	0.56	3
CABP5	Physical association	Medium	0.56	30
CASP6	Physical association	Medium	0.56	122
CATSPERD	Physical association	Medium	0.56	3
CBX1	Physical association	Medium	0.56	26
CBY1	Physical association	Medium	0.56	27
CCDC88B	Physical association	Medium	0.56	32
CCNDBP1	Physical association	Medium	0.56	84
CDIPT	Physical association	Medium	0.56	47
CDKN2D	Physical association	Medium	0.56	41
CEP70	Physical association	Medium	0.56	196
CEP76	Physical association	Medium	0.56	79
CIB3	Physical association	Medium	0.56	44
CIRBP	Physical association	Medium	0.56	11
CLK3	Physical association	Medium	0.56	34
CPNE2	Physical association	Medium	0.56	13
CRX	Physical association	Medium	0.56	74
CYSLTR2	Physical association	Medium	0.56	4
CYSRT1	Physical association	Medium	0.56	396
DCTPP1	Physical association	Medium	0.56	6
DCUN1D5	Physical association	Medium	0.56	6
DDIT3	Physical association	Medium	0.56	30
DERL1	Physical association	Medium	0.56	25
DEUP1	Physical association	Medium	0.56	34
DHPS	Physical association	Medium	0.56	15
DMC1	Physical association	Medium	0.56	10
DPF2	Physical association	Medium	0.56	10
DRAP1	Physical association	Medium	0.56	15
DRG1	Physical association	Medium	0.56	9
DTX2	Physical association	Medium	0.56	95
DUSP29	Physical association	Medium	0.56	15
DYDC1	Physical association	Medium	0.56	24
DYNLT1	Physical association	Medium	0.56	36
EDC3	Physical association	Medium	0.56	12
EEF2KMT	Physical association	Medium	0.56	12
EFEMP2	Physical association	Medium	0.56	83
EFHC2	Physical association	Medium	0.56	79
EGLN3	Physical association	Medium	0.56	17
EIF1AD	Physical association	Medium	0.56	30
EIF4A3	Physical association	Medium	0.56	30
EPM2AIP1	Physical association	Medium	0.56	40
EVI5L	Physical association	Medium	0.56	10
EXOSC1	Physical association	Medium	0.56	19
EXOSC4	Physical association	Medium	0.56	9
EXOSC8	Physical association	Medium	0.56	46
FAM124A	Physical association	Medium	0.56	21
FAM90A1	Physical association	Medium	0.56	128
FAM9B	Physical association	Medium	0.56	118
FASN	Physical association	Medium	0.56	5
FBXL12	Physical association	Medium	0.56	5
FOXP2	Physical association	Medium	0.56	12
FSD2	Physical association	Medium	0.56	73
GFAP	Physical association	Medium	0.56	147
GLRX3	Physical association	Medium	0.56	78
GMCL1	Physical association	Medium	0.56	50
GMNN	Physical association	Medium	0.56	10
GOLPH3L	Physical association	Medium	0.56	3
GPKOW	Physical association	Medium	0.56	40
GRIPAP1	Physical association	Medium	0.56	46
HDX	Physical association	Medium	0.56	10
HEXB	Physical association	Medium	0.56	25
HEXIM2	Physical association	Medium	0.56	38
HIP1	Physical association	Medium	0.56	48
HMBOX1	Physical association	Medium	0.56	76
HMG20A	Physical association	Medium	0.56	52
HNRNPF	Physical association	Medium	0.56	45
HNRNPH1	Physical association	Medium	0.56	30
HOMER3	Physical association	Medium	0.56	65
HSF2BP	Physical association	Medium	0.56	223
HTT	Physical association	Medium	0.56	665
IHO1	Physical association	Medium	0.56	62
IKZF3	Physical association	Medium	0.56	130
INO80E	Physical association	Medium	0.56	19
IP6K3	Physical association	Medium	0.56	13
ISCU	Physical association	Medium	0.56	16
JPH3	Physical association	Medium	0.56	146
KATNAL2	Physical association	Medium	0.56	2
KCTD9	Physical association	Medium	0.56	77
KHDRBS2	Physical association	Medium	0.56	37
KIAA1328	Physical association	Medium	0.56	28
KPRP	Physical association	Medium	0.56	80
KRT16	Physical association	Medium	0.56	46
KRTAP1-1	Physical association	Medium	0.56	150
KRTAP10-8	Physical association	Medium	0.56	325
KRTAP12-3	Physical association	Medium	0.56	117
KRTAP13-3	Physical association	Medium	0.56	58
KRTAP2-4	Physical association	Medium	0.56	77
KRTAP5-9	Physical association	Medium	0.56	166
KRTAP9-2	Physical association	Medium	0.56	123
KRTAP9-3	Physical association	Medium	0.56	103
KRTAP9-8	Physical association	Medium	0.56	72
LCLAT1	Physical association	Medium	0.56	3
LCP2	Physical association	Medium	0.56	16
LDB2	Physical association	Medium	0.56	21
LEPROTL1	Physical association	Medium	0.56	68
LGALS14	Physical association	Medium	0.56	43
LHX2	Physical association	Medium	0.56	20
LONRF1	Physical association	Medium	0.56	77
LRRC73	Physical association	Medium	0.56	7
LSM2	Physical association	Medium	0.56	29
LUZP4	Physical association	Medium	0.56	19
LZTS1	Physical association	Medium	0.56	73
MAD1L1	Physical association	Medium	0.56	38
MAPRE2	Physical association	Medium	0.56	13
MRPS6	Physical association	Medium	0.56	3
MSANTD4	Physical association	Medium	0.56	8
MSC	Physical association	Medium	0.56	3
MVB12B	Physical association	Medium	0.56	1
NAB2	Physical association	Medium	0.56	62
NCK2	Physical association	Medium	0.56	113
NDC80	Physical association	Medium	0.56	42
NDOR1	Physical association	Medium	0.56	21
NDUFAB1	Physical association	Medium	0.56	25
NDUFV2	Physical association	Medium	0.56	59
NECAB1	Physical association	Medium	0.56	9
NEK6	Physical association	Medium	0.56	20
NF2	Physical association	Medium	0.56	28
NME1	Physical association	Medium	0.56	15
NOTCH2NLC	Physical association	Medium	0.56	178
NUP62	Physical association	Medium	0.56	61
NXT2	Physical association	Medium	0.56	10
ODAD1	Physical association	Medium	0.56	7
ORMDL1	Physical association	Medium	0.56	31
OSBP2	Physical association	Medium	0.56	1
OSBPL3	Physical association	Medium	0.56	22
PAK5	Physical association	Medium	0.56	30
PBLD	Physical association	Medium	0.56	8
PDE3B	Physical association	Medium	0.56	5
PFDN5	Physical association	Medium	0.56	81
PNMA3	Physical association	Medium	0.56	10
PNMA5	Physical association	Medium	0.56	53
PNMT	Physical association	Medium	0.56	1
POU6F2	Physical association	Medium	0.56	102
PPIA	Physical association	Medium	0.56	10
PPIH	Physical association	Medium	0.56	11
PPP1R13B	Physical association	Medium	0.56	54
PRDM14	Physical association	Medium	0.56	41
PRKAR1B	Physical association	Medium	0.56	55
PRKRA	Physical association	Medium	0.56	13
PRMT5	Physical association	Medium	0.56	51
PRTFDC1	Physical association	Medium	0.56	13
PSMC1	Physical association	Medium	0.56	27
PSME2	Physical association	Medium	0.56	5
PSME3	Physical association	Medium	0.56	35
PSMF1	Physical association	Medium	0.56	18
PTS	Physical association	Medium	0.56	8
PURB	Physical association	Medium	0.56	6
QARS1	Physical association	Medium	0.56	53
RAB33A	Physical association	Medium	0.56	10
RABIF	Physical association	Medium	0.56	16
RBAK	Physical association	Medium	0.56	20
RBCK1	Physical association	Medium	0.56	21
RBM20	Physical association	Medium	0.56	2
RBMY1F	Physical association	Medium	0.56	29
RBMY1J	Physical association	Medium	0.56	29
RFPL3	Physical association	Medium	0.56	8
RIOX2	Physical association	Medium	0.56	1
RNF11	Physical association	Medium	0.56	153
S100A3	Physical association	Medium	0.56	6
S100B	Physical association	Medium	0.56	32
SCML2	Physical association	Medium	0.56	7
SCNM1	Physical association	Medium	0.56	148
SEPTIN1	Physical association	Medium	0.56	17
SGF29	Physical association	Medium	0.56	35
SNCA	Physical association	Medium	0.56	124
SNRNP25	Physical association	Medium	0.56	15
SNRPA	Physical association	Medium	0.56	36
SNRPF	Physical association	Medium	0.56	20
SP4	Physical association	Medium	0.56	19
SPG21	Physical association	Medium	0.56	129
SPRED1	Physical association	Medium	0.56	308
SRSF3	Physical association	Medium	0.56	17
STAC2	Physical association	Medium	0.56	3
TACO1	Physical association	Medium	0.56	15
TARDBP	Physical association	Medium	0.56	141
TAX1BP1	Physical association	Medium	0.56	58
TBC1D1	Physical association	Medium	0.56	24
TBCEL	Physical association	Medium	0.56	4
TCL1A	Physical association	Medium	0.56	34
TDO2	Physical association	Medium	0.56	19
TEKT4	Physical association	Medium	0.56	80
TGM7	Physical association	Medium	0.56	15
THAP1	Physical association	Medium	0.56	81
THAP7	Physical association	Medium	0.56	47
THG1L	Physical association	Medium	0.56	5
TNFAIP1	Physical association	Medium	0.56	31
TNFAIP3	Physical association	Medium	0.56	14
TRAF3	Physical association	Medium	0.56	29
TRAF4	Physical association	Medium	0.56	73
TRAF5	Physical association	Medium	0.56	35
TRAF6	Physical association	Medium	0.56	60
TRIM14	Physical association	Medium	0.56	26
TRIM21	Physical association	Medium	0.56	24
TRIM27	Physical association	Medium	0.56	232
TRIM3	Physical association	Medium	0.56	12
TRIM39	Physical association	Medium	0.56	28
TRIM42	Physical association	Medium	0.56	112
TRIM50	Physical association	Medium	0.56	31
TRIM60	Physical association	Medium	0.56	1
TRIM68	Physical association	Medium	0.56	9
TRIM8	Physical association	Medium	0.56	17
TRIP6	Physical association	Medium	0.56	90
TRMT12	Physical association	Medium	0.56	2
TSG101	Physical association	Medium	0.56	50
TSN	Physical association	Medium	0.56	10
TSPYL2	Physical association	Medium	0.56	27
UBE2D4	Physical association	Medium	0.56	39
UBP1	Physical association	Medium	0.56	1
VASN	Physical association	Medium	0.56	42
VMAC	Physical association	Medium	0.56	12
VPS37B	Physical association	Medium	0.56	22
VPS52	Physical association	Medium	0.56	83
YWHAZ	Physical association	Medium	0.56	128
ZBED1	Physical association	Medium	0.56	33
ZBTB2	Physical association	Medium	0.56	21
ZBTB24	Physical association	Medium	0.56	52
ZBTB26	Physical association	Medium	0.56	27
ZCCHC10	Physical association	Medium	0.56	33
ZNF213	Physical association	Medium	0.56	7
ZNF263	Physical association	Medium	0.56	12
ZNF346	Physical association	Medium	0.56	9
ZNF426	Physical association	Medium	0.56	33
ZNF552	Physical association	Medium	0.56	27
ZNF593	Physical association	Medium	0.56	3
ZNF655	Physical association	Medium	0.56	117
ZRANB1	Physical association	Medium	0.56	112
SRC	Physical association	Medium	0.56	56
CALCOCO2	Physical association	Medium	0.55	117
CUTC	Physical association	Medium	0.55	12
DCTD	Physical association	Medium	0.55	8
DVL3	Physical association	Medium	0.55	120
FHL3	Physical association	Medium	0.55	103
KCTD17	Physical association	Medium	0.55	29
KHDRBS3	Physical association	Medium	0.55	34
KRTAP4-12	Physical association	Medium	0.55	74
LDOC1	Physical association	Medium	0.55	82
NECAB2	Physical association	Medium	0.55	2
SRSF1	Physical association	Medium	0.55	13
TIFA	Physical association	Medium	0.55	20
ZBTB8A	Physical association	Medium	0.55	58
INPP5K	Physical association	Medium	0.54	10
COIL	Physical association	Medium	0.51	35
GRAP2	Physical association	Medium	0.49	41
JAK3	Physical association	Medium	0.49	3
SH2D2A	Physical association	Medium	0.49	18
SOCS6	Physical association	Medium	0.49	13
NUMB	Physical association	Medium	0.46	10
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
LNX1 is not a metabolic protein