Protein interactions for IKZF3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	IKZF3
Gene descriptionⁱ Full gene name according to HGNC.	IKAROS family zinc finger 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes Disease related genes Human disease related genes Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	15

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Lymphoid tissue - Cytokine signaling (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Group enriched (intestine, lymphoid tissue)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.79
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nucleoplasm In addition localized to the Cytosol
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Lymphoid tissue - Cytokine signaling

Field

Cluster

Pathway

Number of interactions:

130

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
PRKAB2	Physical association	High	0.91	126
ATPAF2	Physical association	High	0.85	57
EFHC1	Physical association	High	0.85	61
RAD51D	Physical association	High	0.85	35
TSTD2	Physical association	High	0.85	16
ARMC7	Physical association	High	0.84	58
POLR1C	Physical association	High	0.84	87
TBC1D22B	Physical association	High	0.83	46
GRB2	Physical association	High	0.79	165
EXOC8	Physical association	High	0.78	67
EXOSC5	Physical association	High	0.78	42
LGALS14	Physical association	High	0.78	43
MAGOHB	Physical association	High	0.78	56
MORN3	Physical association	High	0.78	57
PFDN5	Physical association	High	0.78	81
TEKT4	Physical association	High	0.78	80
PPP1R16B	Physical association	High	0.76	31
CDKN2D	Physical association	High	0.74	41
NEK6	Physical association	High	0.74	20
TCAF1	Physical association	High	0.74	9
AQP1	Physical association	High	0.72	106
C1orf109	Physical association	High	0.72	121
FARS2	Physical association	High	0.72	56
GEM	Physical association	High	0.72	88
KAT5	Physical association	High	0.72	180
PIN1	Physical association	High	0.72	112
SPG21	Physical association	High	0.72	129
TSSK3	Physical association	High	0.72	51
CABP5	Physical association	High	0.7	30
ABLIM3	Physical association	High	0.67	2
BCAS2	Physical association	High	0.67	49
CHCHD2	Physical association	High	0.67	24
LMO1	Physical association	High	0.67	88
OSGIN1	Physical association	High	0.67	30
PIK3R2	Physical association	High	0.67	21
RCOR3	Physical association	High	0.67	24
IKZF5	Physical association	Medium	0.56	1
ARHGEF6	Physical association	Medium	0.56	13
ATP6V0D2	Physical association	Medium	0.56	11
BLK	Physical association	Medium	0.56	22
BLZF1	Physical association	Medium	0.56	84
BYSL	Physical association	Medium	0.56	119
C2CD6	Physical association	Medium	0.56	44
CATSPER1	Physical association	Medium	0.56	95
CCDC102B	Physical association	Medium	0.56	87
CCDC24	Physical association	Medium	0.56	28
CDC37	Physical association	Medium	0.56	124
CDC7	Physical association	Medium	0.56	21
CDK18	Physical association	Medium	0.56	45
CDK4	Physical association	Medium	0.56	24
CDKN1A	Physical association	Medium	0.56	49
CFAP206	Physical association	Medium	0.56	46
CKS1B	Physical association	Medium	0.56	43
CRYBA4	Physical association	Medium	0.56	10
DTX2	Physical association	Medium	0.56	95
EGLN3	Physical association	Medium	0.56	17
EHHADH	Physical association	Medium	0.56	94
EMC2	Physical association	Medium	0.56	9
ENKD1	Physical association	Medium	0.56	159
FAM50B	Physical association	Medium	0.56	39
FANCL	Physical association	Medium	0.56	36
FRS3	Physical association	Medium	0.56	77
GOLGA6A	Physical association	Medium	0.56	37
HNRNPF	Physical association	Medium	0.56	45
HOXC8	Physical association	Medium	0.56	74
HSPB7	Physical association	Medium	0.56	15
ING5	Physical association	Medium	0.56	21
KANK2	Physical association	Medium	0.56	151
KIF9	Physical association	Medium	0.56	42
KLHL38	Physical association	Medium	0.56	72
KRT19	Physical association	Medium	0.56	65
LENG1	Physical association	Medium	0.56	63
LMO2	Physical association	Medium	0.56	61
LMO4	Physical association	Medium	0.56	85
LNX1	Physical association	Medium	0.56	333
LONRF1	Physical association	Medium	0.56	77
MAD2L2	Physical association	Medium	0.56	32
MCRS1	Physical association	Medium	0.56	97
MIPOL1	Physical association	Medium	0.56	58
MISP	Physical association	Medium	0.56	44
MKRN3	Physical association	Medium	0.56	118
MRPL28	Physical association	Medium	0.56	19
MRPL53	Physical association	Medium	0.56	11
NATD1	Physical association	Medium	0.56	7
NFKBID	Physical association	Medium	0.56	83
NME7	Physical association	Medium	0.56	62
NOS3	Physical association	Medium	0.56	40
NUDT16L1	Physical association	Medium	0.56	13
OAZ3	Physical association	Medium	0.56	8
PCID2	Physical association	Medium	0.56	3
PKN1	Physical association	Medium	0.56	59
PPP1R18	Physical association	Medium	0.56	68
PRKAA1	Physical association	Medium	0.56	33
PRKAA2	Physical association	Medium	0.56	78
PRPF18	Physical association	Medium	0.56	63
PSMA1	Physical association	Medium	0.56	135
PTK6	Physical association	Medium	0.56	22
RHOA	Physical association	Medium	0.56	20
SCNM1	Physical association	Medium	0.56	148
SMARCD1	Physical association	Medium	0.56	104
STAMBPL1	Physical association	Medium	0.56	22
STK16	Physical association	Medium	0.56	66
STX11	Physical association	Medium	0.56	80
TCAP	Physical association	Medium	0.56	34
TCHP	Physical association	Medium	0.56	40
TEKT3	Physical association	Medium	0.56	28
TFAP2D	Physical association	Medium	0.56	48
TLE5	Physical association	Medium	0.56	105
TRAPPC6A	Physical association	Medium	0.56	4
TRIM42	Physical association	Medium	0.56	112
TSEN15	Physical association	Medium	0.56	21
TSGA10IP	Physical association	Medium	0.56	83
USP2	Physical association	Medium	0.56	78
VBP1	Physical association	Medium	0.56	26
YES1	Physical association	Medium	0.56	44
ZGPAT	Physical association	Medium	0.56	25
ZMYM2	Physical association	Medium	0.56	6
ZNF417	Physical association	Medium	0.56	140
ZNF587	Physical association	Medium	0.56	102
ZNF76	Physical association	Medium	0.56	62
UBE2I	Physical association	Medium	0.55	40
FOXP3	Physical association	Medium	0.52	11
ATP6V0D1	Physical association	Medium	0.49	6
CRK	Physical association	Medium	0.49	54
FANCG	Physical association	Medium	0.49	35
FHL3	Physical association	Medium	0.49	103
GOLGA2	Physical association	Medium	0.49	349
GRAP2	Physical association	Medium	0.49	41
NTAQ1	Physical association	Medium	0.49	302
PSMF1	Physical association	Medium	0.49	18
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
IKZF3 is not a metabolic protein