Protein interactions for GRB2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GRB2
Gene descriptionⁱ Full gene name according to HGNC.	Growth factor receptor bound protein 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes Plasma proteins RAS pathway related proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Lymphoid tissue - Immune response (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.21
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nucleoplasm
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Lymphoid tissue - Immune response

Field

Cluster

Pathway

Number of interactions:

165

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
EGFR	Direct interaction	High	0.98	270
SHC1	Direct interaction	High	0.97	17
SOS1	Direct interaction	High	0.97	16
CBL	Physical association	High	0.96	34
CBLB	Physical association	High	0.96	25
GAB2	Physical association	High	0.95	9
SOS2	Physical association	High	0.93	6
WASL	Physical association	High	0.93	23
ERRFI1	Physical association	High	0.93	4
PTPRA	Direct interaction	High	0.92	3
STAMBP	Physical association	High	0.92	21
DNM2	Direct interaction	High	0.92	25
LCP2	Direct interaction	High	0.92	16
ERBB2	Direct interaction	High	0.92	49
GAREM1	Physical association	High	0.9	4
GAB1	Direct interaction	High	0.9	10
ASAP1	Physical association	High	0.89	11
PTPN11	Physical association	High	0.89	25
KHDRBS1	Physical association	High	0.87	20
PIK3R1	Physical association	High	0.86	41
MAP4K5	Physical association	High	0.86	2
HNRNPK	Physical association	High	0.85	49
VAV3	Physical association	High	0.85	4
DNM1	Direct interaction	High	0.83	10
WIPF2	Physical association	High	0.8	4
IKZF3	Physical association	High	0.79	130
PTPN23	Physical association	High	0.79	13
MAP4K1	Physical association	High	0.78	9
ARHGEF5	Physical association	High	0.77	18
DOCK1	Physical association	High	0.75	5
WIPF1	Physical association	High	0.75	10
PIK3C2B	Physical association	High	0.74	5
BLNK	Direct interaction	High	0.74	3
KIT	Direct interaction	High	0.74	7
PIK3CA	Physical association	High	0.74	10
PIK3AP1	Physical association	High	0.74	1
THEMIS	Physical association	High	0.74	3
FGFR2	Direct interaction	High	0.74	7
ADAM15	Direct interaction	High	0.71	19
LAT	Physical association	High	0.71	6
ASAP2	Physical association	High	0.68	4
ERBB3	Physical association	High	0.68	19
PPP3CA	Physical association	High	0.68	4
MED28	Direct interaction	High	0.68	18
DBN1	Physical association	High	0.67	7
TSPAN2	Direct interaction	High	0.67	34
MAP2	Direct interaction	High	0.67	1
PIK3R3	Physical association	High	0.67	70
PRMT5	Physical association	High	0.67	51
SPATA2L	Physical association	High	0.67	16
TYRO3	Physical association	High	0.67	13
INCA1	Physical association	High	0.67	204
LNX1	Physical association	High	0.67	333
SH2D4A	Physical association	High	0.67	63
WBP11	Physical association	High	0.67	17
VAV1	Physical association	High	0.66	7
CD2AP	Physical association	High	0.66	11
DOCK4	Physical association	High	0.66	1
GIT1	Physical association	High	0.66	17
HSPA5	Physical association	High	0.66	22
MYH9	Physical association	High	0.66	11
PIK3R2	Physical association	High	0.66	21
PTK2	Physical association	High	0.66	24
RAPGEF1	Direct interaction	High	0.66	5
TNK2	Direct interaction	High	0.66	12
PTPN6	Physical association	High	0.65	19
PTPN1	Direct interaction	High	0.64	27
PLD2	Physical association	High	0.64	4
ACAP1	Physical association	High	0.63	7
RB1	Physical association	High	0.61	36
ADAM10	Direct interaction	High	0.6	17
REPS2	Direct interaction	High	0.6	5
SPRY2	Direct interaction	Medium	0.59	51
LY6G6F	Physical association	Medium	0.59	2
DAB2	Physical association	Medium	0.57	7
DLGAP1	Physical association	Medium	0.57	2
ERBB4	Physical association	Medium	0.57	14
MAP4K3	Physical association	Medium	0.57	3
SF3B4	Physical association	Medium	0.57	32
SYNJ2	Physical association	Medium	0.57	2
LMX1A	Physical association	Medium	0.57	1
PPARA	Physical association	Medium	0.57	18
SOCS4	Physical association	Medium	0.57	14
VCP	Physical association	Medium	0.57	48
AGER	Physical association	Medium	0.56	12
DARS1	Physical association	Medium	0.56	3
FLNA	Physical association	Medium	0.56	18
FLNB	Physical association	Medium	0.56	8
PLCG1	Physical association	Medium	0.56	27
ABI3	Physical association	Medium	0.56	50
AGR2	Physical association	Medium	0.56	62
ANKRD23	Physical association	Medium	0.56	17
ARHGAP9	Physical association	Medium	0.56	10
ARHGDIB	Physical association	Medium	0.56	3
ARID5A	Physical association	Medium	0.56	94
ASCL4	Physical association	Medium	0.56	34
BECN1	Physical association	Medium	0.56	48
BTG1	Physical association	Medium	0.56	6
C1orf94	Physical association	Medium	0.56	69
DDIT4L	Physical association	Medium	0.56	168
DDX17	Physical association	Medium	0.56	20
DPPA4	Physical association	Medium	0.56	20
DTX3	Physical association	Medium	0.56	20
EFHC2	Physical association	Medium	0.56	79
EIF2B4	Physical association	Medium	0.56	9
EPS8	Physical association	Medium	0.56	14
GGN	Physical association	Medium	0.56	14
ITGB3BP	Physical association	Medium	0.56	28
KIAA0408	Physical association	Medium	0.56	24
KLF15	Physical association	Medium	0.56	30
KRTAP19-5	Physical association	Medium	0.56	82
LMO2	Physical association	Medium	0.56	61
LPIN1	Physical association	Medium	0.56	18
LZTS2	Physical association	Medium	0.56	178
MEI4	Physical association	Medium	0.56	32
MYG1	Physical association	Medium	0.56	35
NIF3L1	Physical association	Medium	0.56	52
PNMA5	Physical association	Medium	0.56	53
RAB11B	Physical association	Medium	0.56	9
REL	Physical association	Medium	0.56	141
RNF208	Physical association	Medium	0.56	20
SF3A2	Physical association	Medium	0.56	20
SOCS7	Physical association	Medium	0.56	12
TBC1D3G	Physical association	Medium	0.56	8
TLE5	Physical association	Medium	0.56	105
TMEM185A	Physical association	Medium	0.56	8
TNFAIP1	Physical association	Medium	0.56	31
TRIB3	Physical association	Medium	0.56	54
TRIM27	Physical association	Medium	0.56	232
TXK	Physical association	Medium	0.56	16
VPS37C	Physical association	Medium	0.56	72
WASF1	Physical association	Medium	0.56	15
ZBTB12	Physical association	Medium	0.56	3
ZBTB7B	Physical association	Medium	0.56	11
ZNF232	Physical association	Medium	0.56	21
ZNF341	Physical association	Medium	0.56	9
ZNF474	Physical association	Medium	0.56	18
ZNF620	Physical association	Medium	0.56	51
ZNG1A	Physical association	Medium	0.56	6
EP300	Physical association	Medium	0.55	34
PDCD6IP	Physical association	Medium	0.55	15
PRRC2A	Physical association	Medium	0.55	3
BTK	Physical association	Medium	0.55	12
KRT8	Physical association	Medium	0.55	20
NCL	Physical association	Medium	0.55	13
SPTBN1	Physical association	Medium	0.55	6
TFG	Physical association	Medium	0.55	45
WDR1	Physical association	Medium	0.55	1
WDR44	Physical association	Medium	0.55	2
SRGAP3	Direct interaction	Medium	0.54	2
PTPN22	Direct interaction	Medium	0.54	7
PAK2	Physical association	Medium	0.52	19
RHOU	Physical association	Medium	0.52	5
TOM1L1	Physical association	Medium	0.52	6
NFE2L2	Physical association	Medium	0.51	44
PRKAB1	Physical association	Medium	0.51	7
EPHB1	Physical association	Medium	0.5	3
AUNIP	Physical association	Medium	0.49	9
DVL2	Physical association	Medium	0.49	43
KPRP	Physical association	Medium	0.49	80
LNX2	Physical association	Medium	0.49	63
MYOZ1	Physical association	Medium	0.49	28
PCDHB5	Physical association	Medium	0.49	2
UQCC2	Physical association	Medium	0.49	9
WDFY3	Physical association	Medium	0.49	10
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
GRB2 is not a metabolic protein