Protein interactions for EGFR - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EGFR
Gene descriptionⁱ Full gene name according to HGNC.	Epidermal growth factor receptor
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes Disease related genes Enzymes FDA approved drug targets Human disease related genes Metabolic proteins Plasma proteins RAS pathway related proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Secreted, Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Placenta - Pregnancy (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enhanced (placenta)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.39
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Plasma membrane, Cell Junctions In addition localized to the Nucleoplasm, Nucleoli
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Secreted to blood

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Placenta - Pregnancy

Field

Cluster

Pathway

Number of interactions:

270

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
GRB2	Direct interaction	High	0.98	165
SHC1	Direct interaction	High	0.98	17
EGF	Direct interaction	High	0.97	2
CBL	Direct interaction	High	0.96	34
ERBB2	Physical association	High	0.95	49
STAT3	Physical association	High	0.92	55
ERBB3	Physical association	High	0.91	19
SRC	Physical association	High	0.9	56
PTPN1	Direct interaction	High	0.9	27
HSP90AB1	Physical association	High	0.89	137
ERRFI1	Direct interaction	High	0.87	4
YWHAQ	Physical association	High	0.85	54
PLCG1	Direct interaction	High	0.85	27
SFN	Physical association	High	0.83	39
AP2M1	Physical association	High	0.83	38
NCK1	Direct interaction	High	0.82	24
PTPN11	Direct interaction	High	0.82	25
LYN	Physical association	High	0.82	29
MUC1	Physical association	High	0.82	4
CAV1	Physical association	High	0.81	28
PIK3C2B	Direct interaction	High	0.81	5
PIK3R1	Direct interaction	High	0.81	41
HDAC6	Direct interaction	High	0.81	19
PTPN12	Physical association	High	0.81	8
HSPA8	Physical association	High	0.8	35
MET	Direct interaction	High	0.8	16
ANKS1A	Direct interaction	High	0.79	3
PLCG2	Direct interaction	High	0.79	11
CDC37	Physical association	High	0.79	124
GAPDH	Physical association	High	0.79	28
TXN	Physical association	High	0.79	26
TGFA	Direct interaction	High	0.78	3
HSP90AA1	Physical association	High	0.78	51
STAT1	Physical association	High	0.77	19
SH2B1	Direct interaction	High	0.77	2
ANXA1	Physical association	High	0.77	6
YWHAZ	Physical association	High	0.77	128
PIK3R2	Direct interaction	High	0.76	21
PIK3R3	Direct interaction	High	0.76	70
CRKL	Physical association	High	0.75	24
CTNND1	Physical association	High	0.75	5
HSPA9	Physical association	High	0.75	10
PTK2	Physical association	High	0.75	24
TUBA1A	Physical association	High	0.75	7
S100A4	Direct interaction	High	0.74	13
LRIG1	Physical association	High	0.74	5
APBB2	Direct interaction	High	0.74	2
CISH	Direct interaction	High	0.74	4
BAIAP2	Physical association	High	0.74	12
CDH1	Physical association	High	0.74	35
GAB1	Physical association	High	0.74	10
GRB10	Direct interaction	High	0.73	6
STUB1	Physical association	High	0.72	54
EPS8	Physical association	High	0.71	14
VAPA	Physical association	High	0.71	37
SH3KBP1	Physical association	High	0.69	33
ABL1	Direct interaction	High	0.69	30
ABL2	Direct interaction	High	0.69	6
BLK	Direct interaction	High	0.69	22
CRK	Direct interaction	High	0.69	54
MAPK8IP2	Direct interaction	High	0.69	4
PTPRB	Direct interaction	High	0.69	3
SLA	Direct interaction	High	0.69	1
ZAP70	Direct interaction	High	0.69	5
FKBP8	Physical association	High	0.68	32
PDGFRA	Physical association	High	0.68	5
TNS3	Physical association	High	0.68	5
CSK	Physical association	High	0.68	10
PDCD6IP	Physical association	High	0.68	15
SH3BGRL	Physical association	High	0.68	1
SH3GL2	Physical association	High	0.68	16
TLR2	Physical association	High	0.68	6
AGO2	Direct interaction	High	0.68	28
GAB2	Physical association	High	0.67	9
CFL1	Physical association	High	0.67	12
HSPA4	Physical association	High	0.67	5
AHNAK	Physical association	High	0.67	2
CAV2	Physical association	High	0.67	3
CDK1	Physical association	High	0.67	19
EZR	Physical association	High	0.65	17
HCK	Physical association	High	0.65	17
ITSN2	Physical association	High	0.65	1
JUP	Physical association	High	0.65	14
TAB1	Physical association	High	0.65	14
AP1B1	Physical association	High	0.65	3
GOLM1	Direct interaction	High	0.64	45
AKAP12	Physical association	High	0.63	2
CAMLG	Physical association	High	0.63	18
CTTN	Physical association	High	0.63	5
FGR	Physical association	High	0.63	2
GABARAPL2	Physical association	High	0.63	74
GRAP2	Physical association	High	0.63	41
HDAC7	Physical association	High	0.63	6
LAT	Physical association	High	0.63	6
LCP2	Physical association	High	0.63	16
MAST1	Physical association	High	0.63	3
NR3C1	Physical association	High	0.63	10
PRKCA	Physical association	High	0.63	57
PTPN22	Physical association	High	0.63	7
PTPRA	Physical association	High	0.63	3
SH2D3A	Physical association	High	0.63	1
SHC4	Physical association	High	0.63	1
STAT5A	Physical association	High	0.63	7
STIP1	Physical association	High	0.63	19
TRAF2	Physical association	High	0.63	237
UCHL1	Physical association	High	0.63	29
BECN1	Physical association	High	0.63	48
IQGAP1	Direct interaction	High	0.63	21
MAP3K12	Physical association	High	0.62	2
EPGN	Direct interaction	High	0.62	1
EREG	Direct interaction	High	0.62	5
HBEGF	Direct interaction	High	0.61	3
LAPTM4B	Physical association	Medium	0.6	19
RABGEF1	Physical association	Medium	0.6	13
PTPRC	Direct interaction	Medium	0.59	6
MIF	Physical association	Medium	0.59	4
ANXA2	Physical association	Medium	0.58	9
STAM2	Physical association	Medium	0.58	31
AURKA	Direct interaction	Medium	0.58	16
ROR1	Physical association	Medium	0.58	2
PTPRG	Physical association	Medium	0.57	3
APPL1	Direct interaction	Medium	0.57	33
NUMB	Direct interaction	Medium	0.57	10
NUMBL	Direct interaction	Medium	0.57	4
ERCC1	Physical association	Medium	0.57	9
ERBB4	Physical association	Medium	0.56	14
FKBP5	Physical association	Medium	0.56	11
RUBCN	Physical association	Medium	0.56	14
SOS1	Physical association	Medium	0.56	16
YES1	Physical association	Medium	0.56	44
CMTM8	Physical association	Medium	0.56	3
TOM1L1	Physical association	Medium	0.56	6
ACTN4	Physical association	Medium	0.55	14
ADRM1	Physical association	Medium	0.55	9
AHSA1	Physical association	Medium	0.55	4
AIP	Physical association	Medium	0.55	5
AKT1	Physical association	Medium	0.55	58
ALDOA	Physical association	Medium	0.55	3
APP	Physical association	Medium	0.55	312
ARF6	Physical association	Medium	0.55	7
ARHGEF7	Physical association	Medium	0.55	14
ARPC5	Physical association	Medium	0.55	4
ARRB1	Physical association	Medium	0.55	33
ARRB2	Physical association	Medium	0.55	23
ATIC	Physical association	Medium	0.55	1
CBR1	Physical association	Medium	0.55	2
CDC25C	Physical association	Medium	0.55	8
CEND1	Physical association	Medium	0.55	3
CHD5	Physical association	Medium	0.55	1
CNTN2	Physical association	Medium	0.55	2
COL9A3	Physical association	Medium	0.55	1
CSRP1	Physical association	Medium	0.55	3
DCTN2	Physical association	Medium	0.55	35
DNAJC4	Physical association	Medium	0.55	3
DOK1	Physical association	Medium	0.55	3
DYNC1H1	Physical association	Medium	0.55	34
EEF1G	Physical association	Medium	0.55	9
FAH	Physical association	Medium	0.55	6
FKBP4	Physical association	Medium	0.55	10
FRK	Physical association	Medium	0.55	5
GOT1	Physical association	Medium	0.55	1
GPM6B	Physical association	Medium	0.55	1
GSN	Physical association	Medium	0.55	126
HEXIM1	Physical association	Medium	0.55	6
HSP90B1	Physical association	Medium	0.55	5
IKBKG	Physical association	Medium	0.55	57
ITGB2	Physical association	Medium	0.55	21
ITK	Physical association	Medium	0.55	4
KCTD9	Physical association	Medium	0.55	77
LRP1	Physical association	Medium	0.55	7
MAP3K3	Physical association	Medium	0.55	16
MAP4K1	Physical association	Medium	0.55	9
MAPK8	Physical association	Medium	0.55	10
MAPK9	Physical association	Medium	0.55	48
MAPT	Physical association	Medium	0.55	18
MATR3	Physical association	Medium	0.55	14
MDH1	Physical association	Medium	0.55	2
MEGF6	Physical association	Medium	0.55	3
MGARP	Physical association	Medium	0.55	14
MOB4	Physical association	Medium	0.55	5
NCK2	Physical association	Medium	0.55	113
NDN	Physical association	Medium	0.55	11
NRG1	Physical association	Medium	0.55	1
NTRK2	Physical association	Medium	0.55	2
OAZ1	Physical association	Medium	0.55	2
OLFM1	Physical association	Medium	0.55	1
PAK1	Physical association	Medium	0.55	28
PDK3	Physical association	Medium	0.55	2
PIM1	Physical association	Medium	0.55	7
PIN4	Physical association	Medium	0.55	6
PLCH1	Physical association	Medium	0.55	1
PNPLA2	Physical association	Medium	0.55	1
PPP5C	Physical association	Medium	0.55	15
PRCC	Physical association	Medium	0.55	2
PRDX1	Physical association	Medium	0.55	9
PRKAR1B	Physical association	Medium	0.55	55
PRKCE	Physical association	Medium	0.55	8
PRKCZ	Physical association	Medium	0.55	14
PSMA7	Physical association	Medium	0.55	16
PSMD4	Physical association	Medium	0.55	24
PTGDS	Physical association	Medium	0.55	10
PTPN18	Physical association	Medium	0.55	3
RAB3A	Physical association	Medium	0.55	6
RAF1	Physical association	Medium	0.55	40
RAP1GDS1	Physical association	Medium	0.55	4
RAPGEF1	Physical association	Medium	0.55	5
RET	Physical association	Medium	0.55	5
RGS4	Physical association	Medium	0.55	1
RUSC2	Physical association	Medium	0.55	2
SELENOP	Physical association	Medium	0.55	1
SH2D3C	Physical association	Medium	0.55	2
SH3BGRL3	Physical association	Medium	0.55	2
SH3D21	Physical association	Medium	0.55	1
SH3GL3	Physical association	Medium	0.55	8
SLA2	Physical association	Medium	0.55	2
SNAP25	Physical association	Medium	0.55	6
SNCA	Physical association	Medium	0.55	124
SNX9	Physical association	Medium	0.55	16
SOCS3	Physical association	Medium	0.55	7
SOCS6	Physical association	Medium	0.55	13
SORBS2	Physical association	Medium	0.55	10
SOS2	Physical association	Medium	0.55	6
SPCS2	Physical association	Medium	0.55	3
STAP2	Physical association	Medium	0.55	9
STAT2	Physical association	Medium	0.55	6
SYN1	Physical association	Medium	0.55	1
TMCO3	Physical association	Medium	0.55	1
TNFRSF1A	Physical association	Medium	0.55	7
TPI1	Physical association	Medium	0.55	4
UBE2V2	Physical association	Medium	0.55	2
UROD	Physical association	Medium	0.55	4
VAV1	Physical association	Medium	0.55	7
WASF3	Physical association	Medium	0.55	1
WASL	Physical association	Medium	0.55	23
YWHAB	Physical association	Medium	0.55	78
PTPN6	Physical association	Medium	0.55	19
PTPRD	Physical association	Medium	0.55	2
PTPRF	Physical association	Medium	0.55	2
LRRK1	Direct interaction	Medium	0.54	4
IGFBP3	Physical association	Medium	0.54	5
HGS	Physical association	Medium	0.54	177
AGER	Physical association	Medium	0.52	12
GPNMB	Physical association	Medium	0.52	1
SLC5A1	Physical association	Medium	0.52	1
AMPH	Physical association	Medium	0.51	7
CNKSR2	Physical association	Medium	0.51	2
DOK3	Physical association	Medium	0.51	3
LZTS2	Physical association	Medium	0.51	178
MBIP	Physical association	Medium	0.51	9
PPM1A	Physical association	Medium	0.51	9
PTPRH	Physical association	Medium	0.51	4
SKAP2	Physical association	Medium	0.51	3
TACC3	Physical association	Medium	0.51	20
USP33	Physical association	Medium	0.51	1
ESR2	Physical association	Medium	0.5	6
EXOC4	Physical association	Medium	0.5	18
FANCD2	Physical association	Medium	0.5	10
GABRA2	Physical association	Medium	0.5	1
OS9	Physical association	Medium	0.5	5
SEC61A1	Physical association	Medium	0.5	3
SEL1L	Physical association	Medium	0.5	5
TUBB2A	Physical association	Medium	0.5	9
AXL	Physical association	Medium	0.47	3
HSPH1	Physical association	Medium	0.47	1
EXOC7	Physical association	Medium	0.46	15
GRK2	Physical association	Medium	0.46	11
LRIG2	Physical association	Medium	0.46	2
NEDD4	Physical association	Medium	0.46	18
RIN1	Physical association	Medium	0.46	38
STX6	Physical association	Medium	0.46	24
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene EGFR is associated with 1 reactions in 1 different subsystems, and present in the compartments: Cytosol, Mitochondria. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Transport reactions	Cytosol, Extracellular, Lysosome, Peroxisome, Mitochondria, Golgi apparatus, Endoplasmic reticulum, Nucleus, Inner mitochondria	587	1603	1