Protein interactions for SNCA - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SNCA
Gene descriptionⁱ Full gene name according to HGNC.	Synuclein alpha
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes Plasma proteins Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	16

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Brain & Testis - Signal transduction (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Group enriched (bone marrow, brain)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.54
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Not available
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Brain & Testis - Signal transduction

Field

Cluster

Pathway

Number of interactions:

124

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
SNCAIP	Direct interaction	High	0.83	2
APOE	Direct interaction	High	0.81	30
TPPP	Direct interaction	High	0.72	5
CLU	Physical association	High	0.66	8
APP	Physical association	High	0.66	312
BAX	Physical association	High	0.66	12
YWHAH	Physical association	High	0.65	31
VAMP2	Direct interaction	High	0.63	25
RABAC1	Direct interaction	High	0.63	48
APOA1	Physical association	High	0.62	10
CENPV	Physical association	High	0.61	14
ABL1	Direct interaction	High	0.6	30
SOD1	Physical association	Medium	0.57	50
ABHD17C	Physical association	Medium	0.56	11
AP3B1	Physical association	Medium	0.56	5
ARFGAP3	Physical association	Medium	0.56	29
ASB13	Physical association	Medium	0.56	10
ATF3	Physical association	Medium	0.56	17
ATG10	Physical association	Medium	0.56	10
BCL2L1	Physical association	Medium	0.56	22
BIRC5	Physical association	Medium	0.56	22
BRK1	Physical association	Medium	0.56	46
C6orf141	Physical association	Medium	0.56	8
CASP6	Physical association	Medium	0.56	122
CHMP1A	Physical association	Medium	0.56	14
CLPP	Physical association	Medium	0.56	19
COPS3	Physical association	Medium	0.56	42
CRLF3	Physical association	Medium	0.56	24
CYCS	Physical association	Medium	0.56	17
DEAF1	Physical association	Medium	0.56	9
DLX3	Physical association	Medium	0.56	7
E2F8	Physical association	Medium	0.56	16
ELL2	Physical association	Medium	0.56	16
ENKUR	Physical association	Medium	0.56	9
EXOC5	Physical association	Medium	0.56	46
FEZ2	Physical association	Medium	0.56	12
FOXR1	Physical association	Medium	0.56	14
FTL	Physical association	Medium	0.56	13
FYN	Physical association	Medium	0.56	46
GNB2	Physical association	Medium	0.56	26
H3C1	Physical association	Medium	0.56	52
H3C10	Physical association	Medium	0.56	52
H3C11	Physical association	Medium	0.56	52
H3C12	Physical association	Medium	0.56	52
H3C13	Physical association	Medium	0.56	27
H3C14	Physical association	Medium	0.56	27
H3C15	Physical association	Medium	0.56	27
H3C2	Physical association	Medium	0.56	52
H3C3	Physical association	Medium	0.56	52
H3C4	Physical association	Medium	0.56	52
H3C6	Physical association	Medium	0.56	52
H3C7	Physical association	Medium	0.56	52
H3C8	Physical association	Medium	0.56	52
HDAC10	Physical association	Medium	0.56	6
HES4	Physical association	Medium	0.56	6
HOXC4	Physical association	Medium	0.56	22
INA	Physical association	Medium	0.56	2
ITGB1BP1	Physical association	Medium	0.56	7
KLF15	Physical association	Medium	0.56	30
KLHL20	Physical association	Medium	0.56	31
KLK6	Physical association	Medium	0.56	100
KRTAP9-2	Physical association	Medium	0.56	123
LDHAL6B	Physical association	Medium	0.56	17
LHX5	Physical association	Medium	0.56	17
LHX6	Physical association	Medium	0.56	18
LNX1	Physical association	Medium	0.56	333
LNX2	Physical association	Medium	0.56	63
LSM8	Physical association	Medium	0.56	12
LYN	Physical association	Medium	0.56	29
METTL27	Physical association	Medium	0.56	41
MGARP	Physical association	Medium	0.56	14
MPND	Physical association	Medium	0.56	15
MSRB2	Physical association	Medium	0.56	9
MT2A	Physical association	Medium	0.56	13
NME4	Physical association	Medium	0.56	43
OOSP2	Physical association	Medium	0.56	2
OTUB1	Physical association	Medium	0.56	43
PACS1	Physical association	Medium	0.56	8
PCMTD2	Physical association	Medium	0.56	8
PDZK1IP1	Physical association	Medium	0.56	71
PIAS1	Physical association	Medium	0.56	38
PLEKHG7	Physical association	Medium	0.56	18
PRKCA	Physical association	Medium	0.56	57
PRKCE	Physical association	Medium	0.56	8
PSMC1	Physical association	Medium	0.56	27
PSMC3	Physical association	Medium	0.56	20
RAN	Physical association	Medium	0.56	86
RBM11	Physical association	Medium	0.56	24
RNF10	Physical association	Medium	0.56	13
RNF112	Physical association	Medium	0.56	18
RNF138	Physical association	Medium	0.56	18
RNF168	Physical association	Medium	0.56	5
RNF183	Physical association	Medium	0.56	30
RYBP	Physical association	Medium	0.56	44
SAP30	Physical association	Medium	0.56	8
SDCBP	Physical association	Medium	0.56	240
SEPTIN4	Physical association	Medium	0.56	6
SKIC8	Physical association	Medium	0.56	30
SNCB	Physical association	Medium	0.56	7
SPATA22	Physical association	Medium	0.56	16
SQSTM1	Physical association	Medium	0.56	36
STAM2	Physical association	Medium	0.56	31
TBR1	Physical association	Medium	0.56	7
TDG	Physical association	Medium	0.56	13
TOLLIP	Physical association	Medium	0.56	41
TRIM21	Physical association	Medium	0.56	24
TUBA1B	Physical association	Medium	0.56	4
TUBB	Physical association	Medium	0.56	17
TWIST2	Physical association	Medium	0.56	10
UBA52	Physical association	Medium	0.56	14
UBAC1	Physical association	Medium	0.56	24
UBD	Physical association	Medium	0.56	3
WWP2	Physical association	Medium	0.56	51
ZMAT2	Physical association	Medium	0.56	44
ZNF296	Physical association	Medium	0.56	9
ZNF366	Physical association	Medium	0.56	22
ZNF57	Physical association	Medium	0.56	14
LRRK2	Physical association	Medium	0.56	108
EGFR	Physical association	Medium	0.55	270
GSK3B	Direct interaction	Medium	0.54	28
HTT	Physical association	Medium	0.54	665
SLC6A3	Physical association	Medium	0.54	6
MT-CO3	Physical association	Medium	0.51	1
STX1A	Physical association	Medium	0.5	96
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
SNCA is not a metabolic protein