Protein interactions for SDCBP - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SDCBP
Gene descriptionⁱ Full gene name according to HGNC.	Syndecan binding protein
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Plasma proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Lymphoid tissue - Immune response (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.15
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nucleoplasm, Cytosol In addition localized to the Nuclear membrane
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Lymphoid tissue - Immune response

Field

Cluster

Pathway

Number of interactions:

240

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
RNH1	Physical association	High	0.83	4
KLHL12	Physical association	High	0.79	40
PNMA1	Physical association	High	0.79	114
TIFA	Physical association	High	0.79	20
TRAF5	Physical association	High	0.79	35
CBR3	Physical association	High	0.78	1
CRYAA	Physical association	High	0.78	72
DMC1	Physical association	High	0.78	10
HMGB3	Physical association	High	0.78	5
HPRT1	Physical association	High	0.78	10
NADK	Physical association	High	0.78	6
PNMA2	Physical association	High	0.78	29
TDO2	Physical association	High	0.78	19
TRIM32	Physical association	High	0.78	30
ANP32B	Physical association	High	0.72	10
CDA	Physical association	High	0.72	14
CDC34	Physical association	High	0.72	5
CDCP1	Physical association	High	0.72	4
CEP55	Physical association	High	0.72	56
CLK3	Physical association	High	0.72	34
CT45A3	Physical association	High	0.72	3
CUTC	Physical association	High	0.72	12
DCTD	Physical association	High	0.72	8
EIF1AD	Physical association	High	0.72	30
EIF5A2	Physical association	High	0.72	5
FAM9B	Physical association	High	0.72	118
FTL	Physical association	High	0.72	13
HNRNPC	Physical association	High	0.72	25
HSBP1	Physical association	High	0.72	15
INO80E	Physical association	High	0.72	19
KCTD1	Physical association	High	0.72	16
KCTD6	Physical association	High	0.72	20
KCTD9	Physical association	High	0.72	77
KHDRBS2	Physical association	High	0.72	37
KRTAP5-9	Physical association	High	0.72	166
LDOC1	Physical association	High	0.72	82
LGALS2	Physical association	High	0.72	4
LSM6	Physical association	High	0.72	13
LZTFL1	Physical association	High	0.72	15
MAPRE3	Physical association	High	0.72	41
MRFAP1L1	Physical association	High	0.72	46
NKAPD1	Physical association	High	0.72	38
PSMC6	Physical association	High	0.72	44
PYCR3	Physical association	High	0.72	5
ROPN1	Physical association	High	0.72	37
SEPTIN3	Physical association	High	0.72	14
SREK1IP1	Physical association	High	0.72	25
SRSF7	Physical association	High	0.72	9
SSNA1	Physical association	High	0.72	12
TNFAIP8	Physical association	High	0.72	9
TRIM54	Physical association	High	0.72	151
UBE2A	Physical association	High	0.72	17
WASHC3	Physical association	High	0.72	44
WASL	Physical association	High	0.72	23
ZBTB8A	Physical association	High	0.72	58
ZCCHC17	Physical association	High	0.72	13
DRAP1	Physical association	High	0.7	15
RPL22	Physical association	High	0.7	16
ABI2	Physical association	High	0.67	49
COX4I1	Physical association	High	0.67	3
FLAD1	Physical association	High	0.67	6
PDE4DIP	Physical association	High	0.67	31
PTS	Physical association	High	0.67	8
NECTIN1	Direct interaction	High	0.65	4
FZD7	Direct interaction	High	0.63	18
SMARCA2	Direct interaction	Medium	0.59	8
ANKRD40	Physical association	Medium	0.56	6
APIP	Physical association	Medium	0.56	16
ARFIP2	Physical association	Medium	0.56	42
ARL6IP1	Physical association	Medium	0.56	60
ATXN1	Physical association	Medium	0.56	271
BCL2L15	Physical association	Medium	0.56	6
C11orf68	Physical association	Medium	0.56	4
C1orf109	Physical association	Medium	0.56	121
C1orf35	Physical association	Medium	0.56	32
C2CD2L	Physical association	Medium	0.56	31
CABP5	Physical association	Medium	0.56	30
CALCOCO2	Physical association	Medium	0.56	117
CAV2	Physical association	Medium	0.56	3
CCDC102B	Physical association	Medium	0.56	87
CCDC106	Physical association	Medium	0.56	15
CDIPT	Physical association	Medium	0.56	47
CDKN2D	Physical association	Medium	0.56	41
CGGBP1	Physical association	Medium	0.56	13
CHIC2	Physical association	Medium	0.56	53
CHMP1A	Physical association	Medium	0.56	14
CLK2	Physical association	Medium	0.56	45
CMTM5	Physical association	Medium	0.56	38
CRX	Physical association	Medium	0.56	74
CT45A1	Physical association	Medium	0.56	16
CT45A10	Physical association	Medium	0.56	4
CTDSP1	Physical association	Medium	0.56	20
DCTPP1	Physical association	Medium	0.56	6
DDX39B	Physical association	Medium	0.56	8
DERL3	Physical association	Medium	0.56	14
DNM2	Physical association	Medium	0.56	25
DTNBP1	Physical association	Medium	0.56	22
DYNLT1	Physical association	Medium	0.56	36
EAF1	Physical association	Medium	0.56	41
EDARADD	Physical association	Medium	0.56	8
EIF5A	Physical association	Medium	0.56	9
ELAVL1	Physical association	Medium	0.56	3
EMILIN3	Physical association	Medium	0.56	6
ENOX1	Physical association	Medium	0.56	5
ERICH2	Physical association	Medium	0.56	4
EXOSC4	Physical association	Medium	0.56	9
FADD	Physical association	Medium	0.56	17
FAM118A	Physical association	Medium	0.56	12
FAM118B	Physical association	Medium	0.56	7
FAM9A	Physical association	Medium	0.56	47
FHL3	Physical association	Medium	0.56	103
FHL5	Physical association	Medium	0.56	62
FOXP2	Physical association	Medium	0.56	12
GET4	Physical association	Medium	0.56	10
GGPS1	Physical association	Medium	0.56	2
GKAP1	Physical association	Medium	0.56	11
GOLT1B	Physical association	Medium	0.56	8
GRXCR1	Physical association	Medium	0.56	7
GSC2	Physical association	Medium	0.56	46
HEXIM2	Physical association	Medium	0.56	38
HHAT	Physical association	Medium	0.56	1
HMBOX1	Physical association	Medium	0.56	76
HOMER3	Physical association	Medium	0.56	65
HOXA7	Physical association	Medium	0.56	1
HSF2BP	Physical association	Medium	0.56	223
HTT	Physical association	Medium	0.56	665
HUS1	Physical association	Medium	0.56	6
ID3	Physical association	Medium	0.56	14
IGFBP6	Physical association	Medium	0.56	28
IHO1	Physical association	Medium	0.56	62
IKZF1	Physical association	Medium	0.56	50
KATNBL1	Physical association	Medium	0.56	31
KCNH1	Physical association	Medium	0.56	3
KCNJ2	Physical association	Medium	0.56	7
KLHL2	Physical association	Medium	0.56	23
KRT14	Physical association	Medium	0.56	21
KRTAP1-3	Physical association	Medium	0.56	140
KRTAP1-5	Physical association	Medium	0.56	32
KRTAP10-7	Physical association	Medium	0.56	239
LDB2	Physical association	Medium	0.56	21
LDHB	Physical association	Medium	0.56	7
LEPROTL1	Physical association	Medium	0.56	68
LURAP1L	Physical association	Medium	0.56	5
MAD2L1	Physical association	Medium	0.56	12
MAPK9	Physical association	Medium	0.56	48
MBD3	Physical association	Medium	0.56	14
MED4	Physical association	Medium	0.56	34
MEOX1	Physical association	Medium	0.56	78
MINDY3	Physical association	Medium	0.56	6
MKRN1	Physical association	Medium	0.56	14
MRFAP1	Physical association	Medium	0.56	34
MTUS2	Physical association	Medium	0.56	130
MYLIP	Physical association	Medium	0.56	29
N4BP3	Physical association	Medium	0.56	12
NAGK	Physical association	Medium	0.56	8
NAPB	Physical association	Medium	0.56	28
NOTCH2NLA	Physical association	Medium	0.56	190
NT5C2	Physical association	Medium	0.56	9
OCM	Physical association	Medium	0.56	3
ODAM	Physical association	Medium	0.56	9
OPTN	Physical association	Medium	0.56	127
OSTF1	Physical association	Medium	0.56	8
PCBD1	Physical association	Medium	0.56	12
PCYT1A	Physical association	Medium	0.56	11
PDLIM4	Physical association	Medium	0.56	3
PDZK1IP1	Physical association	Medium	0.56	71
PFDN5	Physical association	Medium	0.56	81
PHC2	Physical association	Medium	0.56	47
PHF11	Physical association	Medium	0.56	4
PIH1D2	Physical association	Medium	0.56	64
POLR2J	Physical association	Medium	0.56	9
POLR3K	Physical association	Medium	0.56	3
PRPF38A	Physical association	Medium	0.56	19
PRR13	Physical association	Medium	0.56	37
PSMB3	Physical association	Medium	0.56	15
PSME2	Physical association	Medium	0.56	5
PSTPIP1	Physical association	Medium	0.56	42
PUF60	Physical association	Medium	0.56	20
RBM39	Physical association	Medium	0.56	23
REEP6	Physical association	Medium	0.56	11
REL	Physical association	Medium	0.56	141
RNF11	Physical association	Medium	0.56	153
RP9	Physical association	Medium	0.56	6
RPIA	Physical association	Medium	0.56	15
RPRM	Physical association	Medium	0.56	66
RPS26	Physical association	Medium	0.56	3
RRM2	Physical association	Medium	0.56	4
RRS1	Physical association	Medium	0.56	3
RTL8B	Physical association	Medium	0.56	7
RUNDC3A	Physical association	Medium	0.56	15
S100B	Physical association	Medium	0.56	32
SCG3	Physical association	Medium	0.56	1
SEPTIN1	Physical association	Medium	0.56	17
SET	Physical association	Medium	0.56	13
SFT2D1	Physical association	Medium	0.56	27
SIAH1	Physical association	Medium	0.56	88
SLC50A1	Physical association	Medium	0.56	3
SNCA	Physical association	Medium	0.56	124
SNRPA	Physical association	Medium	0.56	36
SNX1	Physical association	Medium	0.56	28
SPANXN3	Physical association	Medium	0.56	10
SPRED1	Physical association	Medium	0.56	308
SRSF11	Physical association	Medium	0.56	9
SRSF3	Physical association	Medium	0.56	17
SSC5D	Physical association	Medium	0.56	15
SUB1	Physical association	Medium	0.56	2
SULT1B1	Physical association	Medium	0.56	7
SYPL1	Physical association	Medium	0.56	8
SYS1	Physical association	Medium	0.56	14
TCF21	Physical association	Medium	0.56	3
TEKT1	Physical association	Medium	0.56	21
TFCP2	Physical association	Medium	0.56	44
THG1L	Physical association	Medium	0.56	5
TKFC	Physical association	Medium	0.56	2
TLE5	Physical association	Medium	0.56	105
TMCO2	Physical association	Medium	0.56	3
TMEM17	Physical association	Medium	0.56	4
TMEM239	Physical association	Medium	0.56	10
TNFAIP8L3	Physical association	Medium	0.56	2
TNKS	Physical association	Medium	0.56	14
TRIM27	Physical association	Medium	0.56	232
TRIM38	Physical association	Medium	0.56	17
TRIP13	Physical association	Medium	0.56	71
TSN	Physical association	Medium	0.56	10
UBB	Physical association	Medium	0.56	31
UBE2K	Physical association	Medium	0.56	60
UBE2R2	Physical association	Medium	0.56	4
VAPB	Physical association	Medium	0.56	33
WFS1	Physical association	Medium	0.56	315
YIF1A	Physical association	Medium	0.56	66
ZBTB14	Physical association	Medium	0.56	54
ZCCHC10	Physical association	Medium	0.56	33
ZMYND12	Physical association	Medium	0.56	66
ZNF343	Physical association	Medium	0.56	18
ZNF485	Physical association	Medium	0.56	2
ZNF660	Physical association	Medium	0.56	4
ZNF768	Physical association	Medium	0.56	9
ZRANB1	Physical association	Medium	0.56	112
ZSCAN23	Physical association	Medium	0.56	17
CD6	Physical association	Medium	0.46	5
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
SDCBP is not a metabolic protein