Protein interactions for PNMA1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PNMA1
Gene descriptionⁱ Full gene name according to HGNC.	PNMA family member 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Neuronal - Transcription (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.31
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Cytosol In addition localized to the Nucleoplasm
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Neuronal - Transcription

Field

Cluster

Pathway

Number of interactions:

114

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
PRPF31	Physical association	High	0.86	118
ZCCHC12	Physical association	High	0.85	18
RUSC1	Physical association	High	0.79	71
SCNM1	Physical association	High	0.79	148
SDCBP	Physical association	High	0.79	240
ZNF581	Physical association	High	0.79	82
METTL17	Physical association	High	0.78	11
PNMA6A	Physical association	High	0.78	4
SPG7	Physical association	High	0.78	17
NTAQ1	Physical association	High	0.76	302
HOXB9	Physical association	High	0.72	42
MRPL11	Physical association	High	0.72	24
PNMA5	Physical association	High	0.72	53
PSMA1	Physical association	High	0.72	135
RTP5	Physical association	High	0.72	49
SEMA4C	Physical association	High	0.72	14
SH2D4A	Physical association	High	0.72	63
TNNI1	Physical association	High	0.72	29
ARID5A	Physical association	High	0.7	94
DAXX	Physical association	High	0.7	78
LNX1	Physical association	High	0.7	333
SNRPB2	Physical association	High	0.7	16
SUV39H2	Physical association	High	0.7	10
ATP5PO	Physical association	High	0.67	18
GPANK1	Physical association	High	0.67	65
UBQLN1	Physical association	High	0.67	213
ENKD1	Physical association	High	0.6	159
GTPBP10	Physical association	High	0.6	3
ZC2HC1C	Physical association	High	0.6	18
APTX	Physical association	Medium	0.56	5
ARHGEF6	Physical association	Medium	0.56	13
ASMTL	Physical association	Medium	0.56	8
ATP6V1G1	Physical association	Medium	0.56	8
BEX2	Physical association	Medium	0.56	67
BYSL	Physical association	Medium	0.56	119
C1orf109	Physical association	Medium	0.56	121
C8orf33	Physical association	Medium	0.56	20
CARHSP1	Physical association	Medium	0.56	11
CBX8	Physical association	Medium	0.56	78
CCDC198	Physical association	Medium	0.56	16
CCNG1	Physical association	Medium	0.56	14
CDK18	Physical association	Medium	0.56	45
CFAP53	Physical association	Medium	0.56	23
CHIC2	Physical association	Medium	0.56	53
CNNM3	Physical association	Medium	0.56	59
COX5B	Physical association	Medium	0.56	29
DCTN4	Physical association	Medium	0.56	8
EHHADH	Physical association	Medium	0.56	94
FAM110A	Physical association	Medium	0.56	41
FAM161A	Physical association	Medium	0.56	118
FAM161B	Physical association	Medium	0.56	54
FEM1C	Physical association	Medium	0.56	3
FOXD4L1	Physical association	Medium	0.56	17
FOXD4L3	Physical association	Medium	0.56	14
GADD45GIP1	Physical association	Medium	0.56	55
GEM	Physical association	Medium	0.56	88
GPR25	Physical association	Medium	0.56	27
HAPLN2	Physical association	Medium	0.56	36
HDAC4	Physical association	Medium	0.56	22
INO80B	Physical association	Medium	0.56	49
KANSL1	Physical association	Medium	0.56	22
LAGE3	Physical association	Medium	0.56	19
LIN37	Physical association	Medium	0.56	16
MAB21L2	Physical association	Medium	0.56	11
MACIR	Physical association	Medium	0.56	6
MCM7	Physical association	Medium	0.56	25
MRPL10	Physical association	Medium	0.56	7
MRPL23	Physical association	Medium	0.56	5
MYOZ1	Physical association	Medium	0.56	28
NPBWR2	Physical association	Medium	0.56	15
NUDT16L1	Physical association	Medium	0.56	13
PIN1	Physical association	Medium	0.56	112
PIN4	Physical association	Medium	0.56	6
PKN1	Physical association	Medium	0.56	59
PKN3	Physical association	Medium	0.56	8
PRPF18	Physical association	Medium	0.56	63
RAD51D	Physical association	Medium	0.56	35
RBM41	Physical association	Medium	0.56	23
RPP25	Physical association	Medium	0.56	25
RPP25L	Physical association	Medium	0.56	5
RSPH9	Physical association	Medium	0.56	3
SCAND1	Physical association	Medium	0.56	40
SHC3	Physical association	Medium	0.56	31
SHISA3	Physical association	Medium	0.56	5
SLC25A48	Physical association	Medium	0.56	4
SLIRP	Physical association	Medium	0.56	11
SMIM3	Physical association	Medium	0.56	44
SPATC1L	Physical association	Medium	0.56	9
STAMBPL1	Physical association	Medium	0.56	22
TASOR2	Physical association	Medium	0.56	34
TCEA2	Physical association	Medium	0.56	88
TCEANC	Physical association	Medium	0.56	24
TCL1B	Physical association	Medium	0.56	11
TEAD4	Physical association	Medium	0.56	30
TRIM42	Physical association	Medium	0.56	112
TSHZ2	Physical association	Medium	0.56	15
TSPYL4	Physical association	Medium	0.56	8
TTC9C	Physical association	Medium	0.56	14
TXNDC9	Physical association	Medium	0.56	18
USP2	Physical association	Medium	0.56	78
VBP1	Physical association	Medium	0.56	26
VPS9D1	Physical association	Medium	0.56	21
WDR25	Physical association	Medium	0.56	5
ZNF35	Physical association	Medium	0.56	24
ZNF438	Physical association	Medium	0.56	50
ZNF564	Physical association	Medium	0.56	30
CTDSP1	Physical association	Medium	0.51	20
MARK4	Physical association	Medium	0.5	9
PARD3	Physical association	Medium	0.5	15
PRKCI	Physical association	Medium	0.5	14
EAF2	Physical association	Medium	0.49	13
GRAP2	Physical association	Medium	0.49	41
LSM2	Physical association	Medium	0.49	29
PRKAB2	Physical association	Medium	0.49	126
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
PNMA1 is not a metabolic protein