Protein interactions for FAM161A - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FAM161A
Gene descriptionⁱ Full gene name according to HGNC.	FAM161 centrosomal protein A
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Retina & Testis - Cilium (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enriched (retina)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.73
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Not available
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Retina & Testis - Cilium

Field

Cluster

Pathway

Number of interactions:

118

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
DHX32	Physical association	High	0.84	1
TFIP11	Physical association	High	0.84	179
POC5	Physical association	High	0.8	5
CALCOCO2	Physical association	High	0.72	117
CCDC102B	Physical association	High	0.72	87
CDR2	Physical association	High	0.72	68
CEP70	Physical association	High	0.72	196
HMBOX1	Physical association	High	0.72	76
KRTAP5-9	Physical association	High	0.72	166
LZTS2	Physical association	High	0.72	178
MDFI	Physical association	High	0.72	277
MIPOL1	Physical association	High	0.72	58
TNIP1	Physical association	High	0.72	67
TRIM54	Physical association	High	0.72	151
ZBTB1	Physical association	High	0.72	13
ZBTB8A	Physical association	High	0.72	58
CCNDBP1	Physical association	High	0.7	84
GOLGA2	Physical association	High	0.7	349
TRAF1	Physical association	High	0.7	166
CARD9	Physical association	High	0.67	52
PPFIA1	Physical association	High	0.67	11
AQP1	Physical association	Medium	0.56	106
AXIN2	Physical association	Medium	0.56	36
BACH2	Physical association	Medium	0.56	40
BEGAIN	Physical association	Medium	0.56	29
BEND3	Physical association	Medium	0.56	5
BEND5	Physical association	Medium	0.56	15
CALCOCO1	Physical association	Medium	0.56	14
CBY2	Physical association	Medium	0.56	51
CCDC125	Physical association	Medium	0.56	53
CCDC13	Physical association	Medium	0.56	37
CCDC185	Physical association	Medium	0.56	34
CCDC57	Physical association	Medium	0.56	32
CCDC88B	Physical association	Medium	0.56	32
CCNC	Physical association	Medium	0.56	69
CDR2L	Physical association	Medium	0.56	49
CEP44	Physical association	Medium	0.56	40
CEP63	Physical association	Medium	0.56	22
CEP72	Physical association	Medium	0.56	19
EVI5	Physical association	Medium	0.56	18
FAM9B	Physical association	Medium	0.56	118
FSD2	Physical association	Medium	0.56	73
GAS8	Physical association	Medium	0.56	97
GOLGA6L9	Physical association	Medium	0.56	177
GPBP1	Physical association	Medium	0.56	11
GPRASP3	Physical association	Medium	0.56	49
GRIPAP1	Physical association	Medium	0.56	46
HEXIM2	Physical association	Medium	0.56	38
HOOK1	Physical association	Medium	0.56	24
IKZF1	Physical association	Medium	0.56	50
INO80E	Physical association	Medium	0.56	19
KANK2	Physical association	Medium	0.56	151
KASH5	Physical association	Medium	0.56	96
KAT5	Physical association	Medium	0.56	180
KDM1A	Physical association	Medium	0.56	86
KIAA0753	Physical association	Medium	0.56	17
KIAA1328	Physical association	Medium	0.56	28
KRTAP10-7	Physical association	Medium	0.56	239
KRTAP10-8	Physical association	Medium	0.56	325
KRTAP10-9	Physical association	Medium	0.56	182
KRTAP2-4	Physical association	Medium	0.56	77
KRTAP5-7	Physical association	Medium	0.56	50
LDOC1	Physical association	Medium	0.56	82
LMNA	Physical association	Medium	0.56	53
LURAP1L	Physical association	Medium	0.56	5
LZTS1	Physical association	Medium	0.56	73
MAGEA11	Physical association	Medium	0.56	46
MCC	Physical association	Medium	0.56	50
MCM6	Physical association	Medium	0.56	16
MKRN1	Physical association	Medium	0.56	14
MTUS2	Physical association	Medium	0.56	130
NINL	Physical association	Medium	0.56	10
NUTM1	Physical association	Medium	0.56	17
OSBPL3	Physical association	Medium	0.56	22
PDE4DIP	Physical association	Medium	0.56	31
PHC2	Physical association	Medium	0.56	47
PICK1	Physical association	Medium	0.56	275
PLEKHG4	Physical association	Medium	0.56	50
PNMA1	Physical association	Medium	0.56	114
PNMA2	Physical association	Medium	0.56	29
PPP2R3C	Physical association	Medium	0.56	10
PRKAR1B	Physical association	Medium	0.56	55
QARS1	Physical association	Medium	0.56	53
RINT1	Physical association	Medium	0.56	68
ROPN1	Physical association	Medium	0.56	37
RUBCN	Physical association	Medium	0.56	14
RUNDC3A	Physical association	Medium	0.56	15
SCNM1	Physical association	Medium	0.56	148
SMARCD1	Physical association	Medium	0.56	104
SPRED1	Physical association	Medium	0.56	308
SSX2IP	Physical association	Medium	0.56	78
STX11	Physical association	Medium	0.56	80
SYCE1	Physical association	Medium	0.56	40
TAX1BP1	Physical association	Medium	0.56	58
TBC1D1	Physical association	Medium	0.56	24
TNIP3	Physical association	Medium	0.56	26
TRAF2	Physical association	Medium	0.56	237
TRIB3	Physical association	Medium	0.56	54
TRIM15	Physical association	Medium	0.56	7
TRIM27	Physical association	Medium	0.56	232
TRIM37	Physical association	Medium	0.56	31
TRIM41	Physical association	Medium	0.56	108
TXLNB	Physical association	Medium	0.56	61
VIM	Physical association	Medium	0.56	86
VPS52	Physical association	Medium	0.56	83
ZBTB14	Physical association	Medium	0.56	54
ZBTB43	Physical association	Medium	0.56	21
ZIM2	Physical association	Medium	0.56	26
ZNF24	Physical association	Medium	0.56	26
ZNF276	Physical association	Medium	0.56	9
ZNF426	Physical association	Medium	0.56	33
ZNF526	Physical association	Medium	0.56	45
ZNF792	Physical association	Medium	0.56	46
ZRANB1	Physical association	Medium	0.56	112
ZSCAN12	Physical association	Medium	0.56	20
CFAP418	Physical association	Medium	0.5	3
DVL2	Physical association	Medium	0.49	43
TSGA10	Physical association	Medium	0.49	54
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
FAM161A is not a metabolic protein