Protein interactions for RINT1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RINT1
Gene descriptionⁱ Full gene name according to HGNC.	RAD50 interactor 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Basic cellular processes (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.21
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Golgi apparatus
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Basic cellular processes

Field

Cluster

Pathway

Number of interactions:

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
ZW10	Physical association	High	0.82	3
RIBC1	Physical association	High	0.78	21
SGF29	Physical association	High	0.78	35
SNW1	Physical association	High	0.78	89
C1orf109	Physical association	High	0.72	121
CWF19L2	Physical association	High	0.72	65
FAM110A	Physical association	High	0.72	41
RBM41	Physical association	High	0.72	23
SH2D4A	Physical association	High	0.72	63
TXLNA	Physical association	High	0.72	76
EPC1	Physical association	High	0.7	4
SCNM1	Physical association	High	0.7	148
UVRAG	Physical association	High	0.67	10
C19orf25	Physical association	High	0.67	18
CCDC121	Physical association	High	0.67	4
DCX	Physical association	High	0.67	13
FAM81B	Physical association	High	0.67	4
LMO2	Physical association	High	0.67	61
SFR1	Physical association	High	0.67	7
ZNF655	Physical association	High	0.67	117
ARHGAP45	Physical association	Medium	0.56	8
BFSP2	Physical association	Medium	0.56	44
BLOC1S6	Physical association	Medium	0.56	26
C1orf35	Physical association	Medium	0.56	32
CCDC120	Physical association	Medium	0.56	90
CCDC88B	Physical association	Medium	0.56	32
CDR2L	Physical association	Medium	0.56	49
DCTN2	Physical association	Medium	0.56	35
DPF2	Physical association	Medium	0.56	10
EXOC8	Physical association	Medium	0.56	67
FAM124B	Physical association	Medium	0.56	24
FAM161A	Physical association	Medium	0.56	118
FAM161B	Physical association	Medium	0.56	54
FAM90A1	Physical association	Medium	0.56	128
GAS8	Physical association	Medium	0.56	97
HDAC4	Physical association	Medium	0.56	22
HTT	Physical association	Medium	0.56	665
INPP5J	Physical association	Medium	0.56	15
KRT1	Physical association	Medium	0.56	32
LYSMD1	Physical association	Medium	0.56	10
MISP	Physical association	Medium	0.56	44
MYOZ3	Physical association	Medium	0.56	44
NAB2	Physical association	Medium	0.56	62
NFIL3	Physical association	Medium	0.56	9
PIK3R2	Physical association	Medium	0.56	21
PIMREG	Physical association	Medium	0.56	18
PRPF18	Physical association	Medium	0.56	63
RAMAC	Physical association	Medium	0.56	37
RNF39	Physical association	Medium	0.56	6
RTP5	Physical association	Medium	0.56	49
SMARCE1	Physical association	Medium	0.56	56
STRN	Physical association	Medium	0.56	14
SUOX	Physical association	Medium	0.56	67
TACO1	Physical association	Medium	0.56	15
TSEN54	Physical association	Medium	0.56	14
TSHZ2	Physical association	Medium	0.56	15
TSHZ3	Physical association	Medium	0.56	24
USHBP1	Physical association	Medium	0.56	162
UTP14C	Physical association	Medium	0.56	17
VAV3	Physical association	Medium	0.56	4
VPS37C	Physical association	Medium	0.56	72
ZBTB16	Physical association	Medium	0.56	43
ZNF648	Physical association	Medium	0.56	50
ZNF835	Physical association	Medium	0.56	54
ZSCAN5B	Physical association	Medium	0.56	1
FANCG	Physical association	Medium	0.49	35
GRAP2	Physical association	Medium	0.49	41
PRPF31	Physical association	Medium	0.49	118
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
RINT1 is not a metabolic protein