Protein interactions for TRIM54 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TRIM54
Gene descriptionⁱ Full gene name according to HGNC.	Tripartite motif containing 54
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Skeletal muscle - Muscle contraction (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Group enriched (heart muscle, skeletal muscle, tongue)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.84
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Plasma membrane, Cytosol
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Skeletal muscle - Muscle contraction

Field

Cluster

Pathway

Number of interactions:

151

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
KRT6A	Physical association	High	0.86	30
LNX1	Physical association	High	0.78	333
NGLY1	Physical association	High	0.78	12
TBC1D22B	Physical association	High	0.74	46
ARHGEF5	Physical association	High	0.72	18
BYSL	Physical association	High	0.72	119
C1orf109	Physical association	High	0.72	121
CCDC102B	Physical association	High	0.72	87
CDKN1A	Physical association	High	0.72	49
CWF19L2	Physical association	High	0.72	65
DTX2	Physical association	High	0.72	95
ENKD1	Physical association	High	0.72	159
EPM2AIP1	Physical association	High	0.72	40
EXOSC5	Physical association	High	0.72	42
FAM110A	Physical association	High	0.72	41
FAM161A	Physical association	High	0.72	118
INPP5J	Physical association	High	0.72	15
KLHL38	Physical association	High	0.72	72
KRT6B	Physical association	High	0.72	20
KRT6C	Physical association	High	0.72	21
LENG1	Physical association	High	0.72	63
MFAP1	Physical association	High	0.72	79
NTAQ1	Physical association	High	0.72	302
PPP1R18	Physical association	High	0.72	68
SCNM1	Physical association	High	0.72	148
SDCBP	Physical association	High	0.72	240
SH2D1B	Physical association	High	0.72	14
SMARCE1	Physical association	High	0.72	56
SNF8	Physical association	High	0.72	19
SPG21	Physical association	High	0.72	129
TCEA2	Physical association	High	0.72	88
TSHZ3	Physical association	High	0.72	24
USHBP1	Physical association	High	0.72	162
ZBTB16	Physical association	High	0.72	43
ZNF417	Physical association	High	0.72	140
ZNF572	Physical association	High	0.72	58
ZNF587	Physical association	High	0.72	102
IQUB	Physical association	High	0.67	56
KRT4	Physical association	High	0.67	17
OTUB2	Physical association	High	0.67	17
ADCY4	Physical association	Medium	0.56	3
AIFM2	Physical association	Medium	0.56	2
ARFIP2	Physical association	Medium	0.56	42
ARHGEF6	Physical association	Medium	0.56	13
ARMC7	Physical association	Medium	0.56	58
C1orf216	Physical association	Medium	0.56	69
C1orf35	Physical association	Medium	0.56	32
C1QTNF2	Physical association	Medium	0.56	17
C2CD6	Physical association	Medium	0.56	44
CARD9	Physical association	Medium	0.56	52
CBX8	Physical association	Medium	0.56	78
CCDC146	Physical association	Medium	0.56	42
CCDC87	Physical association	Medium	0.56	7
CDC37	Physical association	Medium	0.56	124
CDK18	Physical association	Medium	0.56	45
CENPX	Physical association	Medium	0.56	3
CFAP206	Physical association	Medium	0.56	46
CFAP53	Physical association	Medium	0.56	23
CHCHD2	Physical association	Medium	0.56	24
CRADD	Physical association	Medium	0.56	8
CSNK2B	Physical association	Medium	0.56	24
DCUN1D1	Physical association	Medium	0.56	15
DDX6	Physical association	Medium	0.56	66
DEUP1	Physical association	Medium	0.56	34
DNAL4	Physical association	Medium	0.56	12
DYNC2I2	Physical association	Medium	0.56	11
EHHADH	Physical association	Medium	0.56	94
EIF4E2	Physical association	Medium	0.56	32
ELMO1	Physical association	Medium	0.56	7
ELOA	Physical association	Medium	0.56	38
EXOC8	Physical association	Medium	0.56	67
FAM124A	Physical association	Medium	0.56	21
FAM124B	Physical association	Medium	0.56	24
FAM50B	Physical association	Medium	0.56	39
FAM90A1	Physical association	Medium	0.56	128
FARS2	Physical association	Medium	0.56	56
FBXO16	Physical association	Medium	0.56	4
GAS8	Physical association	Medium	0.56	97
GEM	Physical association	Medium	0.56	88
GNG13	Physical association	Medium	0.56	21
GNL3L	Physical association	Medium	0.56	13
GTF2IRD2	Physical association	Medium	0.56	1
GTF2IRD2B	Physical association	Medium	0.56	1
HAUS1	Physical association	Medium	0.56	83
HGS	Physical association	Medium	0.56	177
HOXB5	Physical association	Medium	0.56	47
ITPKB	Physical association	Medium	0.56	8
KANK2	Physical association	Medium	0.56	151
KAT14	Physical association	Medium	0.56	7
KIF9	Physical association	Medium	0.56	42
KIFC3	Physical association	Medium	0.56	70
KLHL42	Physical association	Medium	0.56	24
KPNA2	Physical association	Medium	0.56	32
KRT1	Physical association	Medium	0.56	32
KRT3	Physical association	Medium	0.56	33
KRT75	Physical association	Medium	0.56	103
KRT76	Physical association	Medium	0.56	33
KRT78	Physical association	Medium	0.56	13
KRT79	Physical association	Medium	0.56	18
LIN37	Physical association	Medium	0.56	16
LMO1	Physical association	Medium	0.56	88
LMO2	Physical association	Medium	0.56	61
LMO4	Physical association	Medium	0.56	85
LSM2	Physical association	Medium	0.56	29
MAD2L2	Physical association	Medium	0.56	32
MBD3	Physical association	Medium	0.56	14
MCM7	Physical association	Medium	0.56	25
MEAF6	Physical association	Medium	0.56	10
MNS1	Physical association	Medium	0.56	23
MYO5B	Physical association	Medium	0.56	3
OSGIN1	Physical association	Medium	0.56	30
OSTF1	Physical association	Medium	0.56	8
PARVG	Physical association	Medium	0.56	23
PICK1	Physical association	Medium	0.56	275
PLK4	Physical association	Medium	0.56	18
PRKAB2	Physical association	Medium	0.56	126
PRPF18	Physical association	Medium	0.56	63
PRR35	Physical association	Medium	0.56	57
PSMA1	Physical association	Medium	0.56	135
RABGEF1	Physical association	Medium	0.56	13
RAD23A	Physical association	Medium	0.56	41
RASSF10	Physical association	Medium	0.56	19
RBM41	Physical association	Medium	0.56	23
RCOR3	Physical association	Medium	0.56	24
RNF4	Physical association	Medium	0.56	80
SEC14L4	Physical association	Medium	0.56	19
SHC3	Physical association	Medium	0.56	31
SMARCD1	Physical association	Medium	0.56	104
SPRING1	Physical association	Medium	0.56	3
SSX2IP	Physical association	Medium	0.56	78
TCHP	Physical association	Medium	0.56	40
TEAD4	Physical association	Medium	0.56	30
TEPSIN	Physical association	Medium	0.56	101
THOC1	Physical association	Medium	0.56	15
TJAP1	Physical association	Medium	0.56	3
TRIML2	Physical association	Medium	0.56	39
TSG101	Physical association	Medium	0.56	50
TSSK3	Physical association	Medium	0.56	51
TTC23	Physical association	Medium	0.56	17
TTC9C	Physical association	Medium	0.56	14
UBE2D1	Physical association	Medium	0.56	39
UBE2D2	Physical association	Medium	0.56	40
UBE2D4	Physical association	Medium	0.56	39
UBL4A	Physical association	Medium	0.56	12
VPS9D1	Physical association	Medium	0.56	21
XAF1	Physical association	Medium	0.56	14
ZGPAT	Physical association	Medium	0.56	25
DCAF8	Physical association	Medium	0.51	9
FBXW2	Physical association	Medium	0.51	9
HDAC10	Physical association	Medium	0.51	6
MYLK2	Physical association	Medium	0.51	4
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
TRIM54 is not a metabolic protein