Protein interactions for SSX2IP - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SSX2IP
Gene descriptionⁱ Full gene name according to HGNC.	SSX family member 2 interacting protein
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Retina & Testis - Cilium (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enhanced (retina, testis)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.53
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Cell Junctions
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Retina & Testis - Cilium

Field

Cluster

Pathway

Number of interactions:

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
WRAP73	Physical association	High	0.74	2
SSX2	Direct interaction	High	0.72	9
SSX2B	Direct interaction	High	0.72	9
MORN4	Physical association	High	0.72	23
PRPF31	Physical association	High	0.72	118
CCNH	Physical association	High	0.67	37
TFIP11	Physical association	High	0.67	179
TOP3B	Physical association	High	0.67	10
XIAP	Physical association	High	0.67	42
ZGPAT	Physical association	High	0.67	25
CEP55	Physical association	High	0.66	56
TRIM37	Physical association	High	0.66	31
ABLIM3	Physical association	Medium	0.56	2
AEN	Physical association	Medium	0.56	27
AP1M1	Physical association	Medium	0.56	67
ATOSA	Physical association	Medium	0.56	5
BEX2	Physical association	Medium	0.56	67
BYSL	Physical association	Medium	0.56	119
C11orf54	Physical association	Medium	0.56	3
CARD9	Physical association	Medium	0.56	52
CCDC198	Physical association	Medium	0.56	16
CDC23	Physical association	Medium	0.56	69
CDCA7L	Physical association	Medium	0.56	52
CHCHD3	Physical association	Medium	0.56	37
DAXX	Physical association	Medium	0.56	78
DRG1	Physical association	Medium	0.56	9
EHHADH	Physical association	Medium	0.56	94
EIF4A2	Physical association	Medium	0.56	12
ERAL1	Physical association	Medium	0.56	5
FAM124B	Physical association	Medium	0.56	24
FAM161A	Physical association	Medium	0.56	118
FANCL	Physical association	Medium	0.56	36
FNDC11	Physical association	Medium	0.56	37
FRMD6	Physical association	Medium	0.56	12
GEM	Physical association	Medium	0.56	88
GOLGA8F	Physical association	Medium	0.56	19
INO80B	Physical association	Medium	0.56	49
KAT5	Physical association	Medium	0.56	180
KLHL42	Physical association	Medium	0.56	24
KRT15	Physical association	Medium	0.56	100
KRT31	Physical association	Medium	0.56	284
KRT40	Physical association	Medium	0.56	288
KRTAP10-7	Physical association	Medium	0.56	239
LMO2	Physical association	Medium	0.56	61
MFAP1	Physical association	Medium	0.56	79
MOS	Physical association	Medium	0.56	46
MRPL53	Physical association	Medium	0.56	11
NAA10	Physical association	Medium	0.56	41
NOL12	Physical association	Medium	0.56	10
PHC2	Physical association	Medium	0.56	47
PIMREG	Physical association	Medium	0.56	18
PKN1	Physical association	Medium	0.56	59
PRKAA1	Physical association	Medium	0.56	33
PRPF3	Physical association	Medium	0.56	35
PSMA1	Physical association	Medium	0.56	135
SCNM1	Physical association	Medium	0.56	148
SHFL	Physical association	Medium	0.56	26
SSX3	Physical association	Medium	0.56	12
SYT17	Physical association	Medium	0.56	34
TRIM42	Physical association	Medium	0.56	112
TRIM54	Physical association	Medium	0.56	151
TSGA10IP	Physical association	Medium	0.56	83
TSTD2	Physical association	Medium	0.56	16
TTC23	Physical association	Medium	0.56	17
WDR5	Physical association	Medium	0.56	48
ZBTB24	Physical association	Medium	0.56	52
ZMAT2	Physical association	Medium	0.56	44
ZNF124	Physical association	Medium	0.56	45
ZNF202	Physical association	Medium	0.56	17
ZNF3	Physical association	Medium	0.56	11
ZNF408	Physical association	Medium	0.56	51
ZNF417	Physical association	Medium	0.56	140
ZNF438	Physical association	Medium	0.56	50
ZNF587	Physical association	Medium	0.56	102
ZNF648	Physical association	Medium	0.56	50
ZNF792	Physical association	Medium	0.56	46
ZRSR2	Physical association	Medium	0.56	13
ZSCAN12	Physical association	Medium	0.56	20
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
SSX2IP is not a metabolic protein