Protein interactions for KRTAP10-7 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	KRTAP10-7
Gene descriptionⁱ Full gene name according to HGNC.	Keratin associated protein 10-7
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Skin - Keratinization (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enriched (skin)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.99
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in single
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Not available
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Skin - Keratinization

Field

Cluster

Pathway

Number of interactions:

239

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
LCE1B	Physical association	High	0.78	69
ZBTB9	Physical association	High	0.74	28
ZSCAN26	Physical association	High	0.74	15
AP1M1	Physical association	High	0.72	67
BUD31	Physical association	High	0.72	3
CHRD	Physical association	High	0.72	40
CLK4	Physical association	High	0.72	6
CRCT1	Physical association	High	0.72	46
DHX57	Physical association	High	0.72	18
FARS2	Physical association	High	0.72	56
GABARAPL2	Physical association	High	0.72	74
GEM	Physical association	High	0.72	88
GSTP1	Physical association	High	0.72	21
IGSF8	Physical association	High	0.72	9
KLHL38	Physical association	High	0.72	72
KRTAP10-8	Physical association	High	0.72	325
KRTAP10-9	Physical association	High	0.72	182
KRTAP12-1	Physical association	High	0.72	50
KRTAP5-6	Physical association	High	0.72	73
KRTAP9-2	Physical association	High	0.72	123
LCE3E	Physical association	High	0.72	46
LCE4A	Physical association	High	0.72	63
MAPKBP1	Physical association	High	0.72	48
MRGBP	Physical association	High	0.72	14
NAXD	Physical association	High	0.72	13
NPDC1	Physical association	High	0.72	27
NUFIP2	Physical association	High	0.72	58
PIN1	Physical association	High	0.72	112
PRKAB2	Physical association	High	0.72	126
PTPMT1	Physical association	High	0.72	25
SMCP	Physical association	High	0.72	67
SPRY1	Physical association	High	0.72	59
SUV39H1	Physical association	High	0.72	52
TOR1A	Physical association	High	0.72	8
ZNF101	Physical association	High	0.72	7
ZNF417	Physical association	High	0.72	140
ZNF490	Physical association	High	0.72	23
ZNF564	Physical association	High	0.72	30
ZNF581	Physical association	High	0.72	82
ZNF587	Physical association	High	0.72	102
CHRNG	Physical association	High	0.67	5
RPF1	Physical association	High	0.67	1
ZNF223	Physical association	High	0.67	6
A2M	Physical association	Medium	0.56	51
AEN	Physical association	Medium	0.56	27
ALDH3B1	Physical association	Medium	0.56	15
AQP1	Physical association	Medium	0.56	106
AVPI1	Physical association	Medium	0.56	29
B4GALT7	Physical association	Medium	0.56	5
BAHD1	Physical association	Medium	0.56	54
BRME1	Physical association	Medium	0.56	19
BYSL	Physical association	Medium	0.56	119
C8orf33	Physical association	Medium	0.56	20
CARHSP1	Physical association	Medium	0.56	11
CATIP	Physical association	Medium	0.56	14
CBX2	Physical association	Medium	0.56	8
CCDC185	Physical association	Medium	0.56	34
CCNG1	Physical association	Medium	0.56	14
CDCA7L	Physical association	Medium	0.56	52
CHIC2	Physical association	Medium	0.56	53
CLK1	Physical association	Medium	0.56	3
CNNM3	Physical association	Medium	0.56	59
COL8A1	Physical association	Medium	0.56	51
CRY2	Physical association	Medium	0.56	29
CSNK1G1	Physical association	Medium	0.56	2
CSNK1G2	Physical association	Medium	0.56	4
CTNNBIP1	Physical association	Medium	0.56	14
CTRC	Physical association	Medium	0.56	12
CYSRT1	Physical association	Medium	0.56	396
DERL2	Physical association	Medium	0.56	8
DMRT3	Physical association	Medium	0.56	65
DOCK2	Physical association	Medium	0.56	36
E2F6	Physical association	Medium	0.56	6
EHHADH	Physical association	Medium	0.56	94
FAM124B	Physical association	Medium	0.56	24
FAM161A	Physical association	Medium	0.56	118
FAM76B	Physical association	Medium	0.56	8
GABARAPL1	Physical association	Medium	0.56	59
GLP1R	Physical association	Medium	0.56	10
GNE	Physical association	Medium	0.56	12
GRN	Physical association	Medium	0.56	216
GUCD1	Physical association	Medium	0.56	6
HBZ	Physical association	Medium	0.56	18
HHEX	Physical association	Medium	0.56	23
HOXC8	Physical association	Medium	0.56	74
HPCAL1	Physical association	Medium	0.56	31
HSBP1	Physical association	Medium	0.56	15
HSD3B7	Physical association	Medium	0.56	42
HTT	Physical association	Medium	0.56	665
ING5	Physical association	Medium	0.56	21
INPP5D	Physical association	Medium	0.56	9
IQUB	Physical association	Medium	0.56	56
ITGB5	Physical association	Medium	0.56	20
KRT20	Physical association	Medium	0.56	32
KRT83	Physical association	Medium	0.56	31
KRTAP10-5	Physical association	Medium	0.56	115
KRTAP12-3	Physical association	Medium	0.56	117
KRTAP26-1	Physical association	Medium	0.56	73
KRTAP4-2	Physical association	Medium	0.56	102
KRTAP4-5	Physical association	Medium	0.56	54
KRTAP5-11	Physical association	Medium	0.56	49
KRTAP5-2	Physical association	Medium	0.56	38
KRTAP5-9	Physical association	Medium	0.56	166
KRTAP9-3	Physical association	Medium	0.56	103
KRTAP9-8	Physical association	Medium	0.56	72
LCE1A	Physical association	Medium	0.56	59
LCE1D	Physical association	Medium	0.56	47
LCE1F	Physical association	Medium	0.56	61
LCE2A	Physical association	Medium	0.56	43
LCE2B	Physical association	Medium	0.56	55
LCE2C	Physical association	Medium	0.56	71
LCE3A	Physical association	Medium	0.56	54
LCE3B	Physical association	Medium	0.56	34
LCE3C	Physical association	Medium	0.56	46
LCE3D	Physical association	Medium	0.56	44
LCE5A	Physical association	Medium	0.56	53
LMNA	Physical association	Medium	0.56	53
LMO2	Physical association	Medium	0.56	61
LRCH4	Physical association	Medium	0.56	14
MCRS1	Physical association	Medium	0.56	97
MOBP	Physical association	Medium	0.56	5
MXD3	Physical association	Medium	0.56	10
MYPOP	Physical association	Medium	0.56	33
NAA10	Physical association	Medium	0.56	41
NECTIN2	Physical association	Medium	0.56	10
NECTIN3	Physical association	Medium	0.56	9
NKD1	Physical association	Medium	0.56	11
NOL12	Physical association	Medium	0.56	10
NOTCH2NLA	Physical association	Medium	0.56	190
NPBWR2	Physical association	Medium	0.56	15
NTAQ1	Physical association	Medium	0.56	302
NUBP2	Physical association	Medium	0.56	10
OTX1	Physical association	Medium	0.56	118
P2RY6	Physical association	Medium	0.56	15
PCED1A	Physical association	Medium	0.56	3
PCSK5	Physical association	Medium	0.56	10
PDIA5	Physical association	Medium	0.56	2
PDLIM5	Physical association	Medium	0.56	9
PFKL	Physical association	Medium	0.56	4
PGAP6	Physical association	Medium	0.56	9
PRM2	Physical association	Medium	0.56	3
PRR13	Physical association	Medium	0.56	37
PRR35	Physical association	Medium	0.56	57
PTGDS	Physical association	Medium	0.56	10
PVR	Physical association	Medium	0.56	52
R3HDM2	Physical association	Medium	0.56	15
RNF175	Physical association	Medium	0.56	1
RPL11	Physical association	Medium	0.56	8
RPL36AL	Physical association	Medium	0.56	1
RPS28	Physical association	Medium	0.56	9
RPUSD3	Physical association	Medium	0.56	4
RSPO2	Physical association	Medium	0.56	4
RTN4RL1	Physical association	Medium	0.56	5
RWDD2B	Physical association	Medium	0.56	9
SCNM1	Physical association	Medium	0.56	148
SDCBP	Physical association	Medium	0.56	240
SHFL	Physical association	Medium	0.56	26
SLC23A1	Physical association	Medium	0.56	10
SLC25A48	Physical association	Medium	0.56	4
SLC6A20	Physical association	Medium	0.56	8
SMCO4	Physical association	Medium	0.56	51
SPACA9	Physical association	Medium	0.56	7
SPG7	Physical association	Medium	0.56	17
SPRED1	Physical association	Medium	0.56	308
SSX2IP	Physical association	Medium	0.56	78
STK16	Physical association	Medium	0.56	66
TCEA2	Physical association	Medium	0.56	88
TCEANC	Physical association	Medium	0.56	24
TEDC2	Physical association	Medium	0.56	6
TFAP2D	Physical association	Medium	0.56	48
THAP1	Physical association	Medium	0.56	81
THAP6	Physical association	Medium	0.56	13
TLE5	Physical association	Medium	0.56	105
TMA16	Physical association	Medium	0.56	6
TNS2	Physical association	Medium	0.56	70
TRIM42	Physical association	Medium	0.56	112
TTPA	Physical association	Medium	0.56	36
TULP3	Physical association	Medium	0.56	15
TYRO3	Physical association	Medium	0.56	13
UCP2	Physical association	Medium	0.56	1
UXT	Physical association	Medium	0.56	21
VASN	Physical association	Medium	0.56	42
VTI1B	Physical association	Medium	0.56	26
WNT11	Physical association	Medium	0.56	17
ZBTB24	Physical association	Medium	0.56	52
ZBTB48	Physical association	Medium	0.56	23
ZFP41	Physical association	Medium	0.56	6
ZIM2	Physical association	Medium	0.56	26
ZNF124	Physical association	Medium	0.56	45
ZNF133	Physical association	Medium	0.56	3
ZNF138	Physical association	Medium	0.56	16
ZNF169	Physical association	Medium	0.56	5
ZNF175	Physical association	Medium	0.56	4
ZNF180	Physical association	Medium	0.56	3
ZNF20	Physical association	Medium	0.56	43
ZNF256	Physical association	Medium	0.56	1
ZNF26	Physical association	Medium	0.56	4
ZNF260	Physical association	Medium	0.56	3
ZNF264	Physical association	Medium	0.56	14
ZNF266	Physical association	Medium	0.56	8
ZNF32	Physical association	Medium	0.56	9
ZNF320	Physical association	Medium	0.56	2
ZNF329	Physical association	Medium	0.56	21
ZNF337	Physical association	Medium	0.56	8
ZNF408	Physical association	Medium	0.56	51
ZNF41	Physical association	Medium	0.56	2
ZNF414	Physical association	Medium	0.56	42
ZNF418	Physical association	Medium	0.56	2
ZNF419	Physical association	Medium	0.56	3
ZNF420	Physical association	Medium	0.56	7
ZNF425	Physical association	Medium	0.56	1
ZNF433	Physical association	Medium	0.56	5
ZNF439	Physical association	Medium	0.56	19
ZNF440	Physical association	Medium	0.56	26
ZNF491	Physical association	Medium	0.56	8
ZNF524	Physical association	Medium	0.56	22
ZNF543	Physical association	Medium	0.56	3
ZNF555	Physical association	Medium	0.56	3
ZNF572	Physical association	Medium	0.56	58
ZNF575	Physical association	Medium	0.56	22
ZNF578	Physical association	Medium	0.56	12
ZNF580	Physical association	Medium	0.56	15
ZNF625	Physical association	Medium	0.56	4
ZNF667	Physical association	Medium	0.56	1
ZNF670	Physical association	Medium	0.56	19
ZNF696	Physical association	Medium	0.56	30
ZNF707	Physical association	Medium	0.56	7
ZNF764	Physical association	Medium	0.56	26
ZNF774	Physical association	Medium	0.56	68
ZNF778	Physical association	Medium	0.56	1
ZNF786	Physical association	Medium	0.56	9
ZNF792	Physical association	Medium	0.56	46
ZNF837	Physical association	Medium	0.56	68
ZNF844	Physical association	Medium	0.56	11
ZNF846	Physical association	Medium	0.56	1
ZNHIT1	Physical association	Medium	0.56	22
ZSCAN10	Physical association	Medium	0.56	1
ZSCAN21	Physical association	Medium	0.56	22
STAT3	Physical association	Medium	0.49	55
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
KRTAP10-7 is not a metabolic protein