Protein interactions for KRTAP10-5 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	KRTAP10-5
Gene descriptionⁱ Full gene name according to HGNC.	Keratin associated protein 10-5
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Skin - Keratinization (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enriched (skin)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	1.00
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in single
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Not available
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Skin - Keratinization

Field

Cluster

Pathway

Number of interactions:

115

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
LCE1B	Physical association	High	0.78	69
LCE3C	Physical association	High	0.74	46
GLRX3	Physical association	High	0.72	78
KRTAP3-2	Physical association	High	0.72	54
KRTAP4-2	Physical association	High	0.72	102
KRTAP5-9	Physical association	High	0.72	166
LCE2A	Physical association	High	0.72	43
LCE3E	Physical association	High	0.72	46
NUFIP2	Physical association	High	0.72	58
OTX1	Physical association	High	0.72	118
ZNF587	Physical association	High	0.72	102
ZNF559	Physical association	High	0.67	8
AEN	Physical association	Medium	0.56	27
ALDH3B1	Physical association	Medium	0.56	15
BYSL	Physical association	Medium	0.56	119
C11orf87	Physical association	Medium	0.56	18
C17orf50	Physical association	Medium	0.56	6
CARD9	Physical association	Medium	0.56	52
CATSPER1	Physical association	Medium	0.56	95
CHRD	Physical association	Medium	0.56	40
CNNM3	Physical association	Medium	0.56	59
CYSRT1	Physical association	Medium	0.56	396
DHX57	Physical association	Medium	0.56	18
ECE1	Physical association	Medium	0.56	5
EIF4E2	Physical association	Medium	0.56	32
ENKD1	Physical association	Medium	0.56	159
FAM76B	Physical association	Medium	0.56	8
FARS2	Physical association	Medium	0.56	56
FBXO34	Physical association	Medium	0.56	18
GATA1	Physical association	Medium	0.56	10
GNE	Physical association	Medium	0.56	12
HHEX	Physical association	Medium	0.56	23
HPCAL1	Physical association	Medium	0.56	31
KRTAP1-3	Physical association	Medium	0.56	140
KRTAP10-6	Physical association	Medium	0.56	65
KRTAP10-7	Physical association	Medium	0.56	239
KRTAP10-8	Physical association	Medium	0.56	325
KRTAP11-1	Physical association	Medium	0.56	83
KRTAP12-1	Physical association	Medium	0.56	50
KRTAP12-2	Physical association	Medium	0.56	97
KRTAP13-2	Physical association	Medium	0.56	57
KRTAP2-3	Physical association	Medium	0.56	9
KRTAP26-1	Physical association	Medium	0.56	73
KRTAP4-12	Physical association	Medium	0.56	74
KRTAP4-4	Physical association	Medium	0.56	56
KRTAP5-6	Physical association	Medium	0.56	73
KRTAP9-2	Physical association	Medium	0.56	123
KRTAP9-3	Physical association	Medium	0.56	103
KRTAP9-4	Physical association	Medium	0.56	25
KRTAP9-8	Physical association	Medium	0.56	72
LCE1C	Physical association	Medium	0.56	55
LCE1D	Physical association	Medium	0.56	47
LCE1E	Physical association	Medium	0.56	52
LCE2C	Physical association	Medium	0.56	71
LCE2D	Physical association	Medium	0.56	51
LCE3B	Physical association	Medium	0.56	34
LCE3D	Physical association	Medium	0.56	44
LCE4A	Physical association	Medium	0.56	63
LCE5A	Physical association	Medium	0.56	53
LELP1	Physical association	Medium	0.56	14
LUZP4	Physical association	Medium	0.56	19
MEOX2	Physical association	Medium	0.56	158
MOBP	Physical association	Medium	0.56	5
NAA10	Physical association	Medium	0.56	41
NECTIN2	Physical association	Medium	0.56	10
NOTCH2NLA	Physical association	Medium	0.56	190
NOTCH2NLC	Physical association	Medium	0.56	178
NPDC1	Physical association	Medium	0.56	27
NR4A1	Physical association	Medium	0.56	15
NR4A3	Physical association	Medium	0.56	30
NTAQ1	Physical association	Medium	0.56	302
POU4F2	Physical association	Medium	0.56	62
PRKAB2	Physical association	Medium	0.56	126
PRKAG1	Physical association	Medium	0.56	21
PRR13	Physical association	Medium	0.56	37
RBP3	Physical association	Medium	0.56	9
SCNM1	Physical association	Medium	0.56	148
SHFL	Physical association	Medium	0.56	26
SLC23A1	Physical association	Medium	0.56	10
SLC6A20	Physical association	Medium	0.56	8
SMCP	Physical association	Medium	0.56	67
SPACA9	Physical association	Medium	0.56	7
SPRY1	Physical association	Medium	0.56	59
SPRY2	Physical association	Medium	0.56	51
STK16	Physical association	Medium	0.56	66
THAP10	Physical association	Medium	0.56	11
TNS2	Physical association	Medium	0.56	70
TRIM42	Physical association	Medium	0.56	112
TULP3	Physical association	Medium	0.56	15
UTP23	Physical association	Medium	0.56	22
YY1	Physical association	Medium	0.56	47
ZBTB24	Physical association	Medium	0.56	52
ZBTB48	Physical association	Medium	0.56	23
ZFYVE21	Physical association	Medium	0.56	22
ZNF124	Physical association	Medium	0.56	45
ZNF20	Physical association	Medium	0.56	43
ZNF273	Physical association	Medium	0.56	1
ZNF32	Physical association	Medium	0.56	9
ZNF320	Physical association	Medium	0.56	2
ZNF329	Physical association	Medium	0.56	21
ZNF34	Physical association	Medium	0.56	2
ZNF417	Physical association	Medium	0.56	140
ZNF433	Physical association	Medium	0.56	5
ZNF439	Physical association	Medium	0.56	19
ZNF440	Physical association	Medium	0.56	26
ZNF572	Physical association	Medium	0.56	58
ZNF578	Physical association	Medium	0.56	12
ZNF670	Physical association	Medium	0.56	19
ZNF679	Physical association	Medium	0.56	4
ZNF696	Physical association	Medium	0.56	30
ZNF707	Physical association	Medium	0.56	7
ZNF785	Physical association	Medium	0.56	13
ZNF792	Physical association	Medium	0.56	46
ZSCAN21	Physical association	Medium	0.56	22
ZSCAN26	Physical association	Medium	0.56	15
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
KRTAP10-5 is not a metabolic protein