Protein interactions for MEOX2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MEOX2
Gene descriptionⁱ Full gene name according to HGNC.	Mesenchyme homeobox 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Adipose tissue - Mixed function (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enhanced (adipose tissue, placenta)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.60
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Not available
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Adipose tissue - Mixed function

Field

Cluster

Pathway

Number of interactions:

158

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
CSF2	Physical association	High	0.72	4
PGBD1	Physical association	High	0.72	11
SMAD3	Physical association	High	0.72	52
CRCT1	Physical association	High	0.67	46
FUCA2	Physical association	High	0.67	12
KRTAP12-1	Physical association	High	0.67	50
SPRY1	Physical association	High	0.67	59
KRTAP10-9	Physical association	High	0.6	182
ACTN4	Physical association	Medium	0.56	14
ADAMTS12	Physical association	Medium	0.56	3
AGPAT1	Physical association	Medium	0.56	1
AHCYL1	Physical association	Medium	0.56	27
ANP32B	Physical association	Medium	0.56	10
ARHGEF7	Physical association	Medium	0.56	14
BCL2L15	Physical association	Medium	0.56	6
BTK	Physical association	Medium	0.56	12
C1orf109	Physical association	Medium	0.56	121
CARD9	Physical association	Medium	0.56	52
CASP14	Physical association	Medium	0.56	2
CCDC103	Physical association	Medium	0.56	17
CCNC	Physical association	Medium	0.56	69
CHIC2	Physical association	Medium	0.56	53
CHRD	Physical association	Medium	0.56	40
CIAPIN1	Physical association	Medium	0.56	6
CIB3	Physical association	Medium	0.56	44
CNTNAP2	Physical association	Medium	0.56	4
CPNE6	Physical association	Medium	0.56	1
CPSF4	Physical association	Medium	0.56	3
CSDC2	Physical association	Medium	0.56	3
CTNNBL1	Physical association	Medium	0.56	11
CXXC1	Physical association	Medium	0.56	5
DGCR8	Physical association	Medium	0.56	4
DOCK8	Physical association	Medium	0.56	7
DYNLL2	Physical association	Medium	0.56	50
DYNLT5	Physical association	Medium	0.56	1
EDF1	Physical association	Medium	0.56	6
EFEMP1	Physical association	Medium	0.56	27
EFEMP2	Physical association	Medium	0.56	83
EFNA3	Physical association	Medium	0.56	4
EIF1AD	Physical association	Medium	0.56	30
EIF5A	Physical association	Medium	0.56	9
EMD	Physical association	Medium	0.56	72
EPM2AIP1	Physical association	Medium	0.56	40
ESRRG	Physical association	Medium	0.56	7
FAM13C	Physical association	Medium	0.56	12
FBLN5	Physical association	Medium	0.56	11
FKBP6	Physical association	Medium	0.56	26
FOXR1	Physical association	Medium	0.56	14
FUT11	Physical association	Medium	0.56	2
GMCL2	Physical association	Medium	0.56	22
GMPR2	Physical association	Medium	0.56	2
GOLGA8F	Physical association	Medium	0.56	19
GPATCH2L	Physical association	Medium	0.56	19
GPSM3	Physical association	Medium	0.56	38
HAT1	Physical association	Medium	0.56	26
HDHD2	Physical association	Medium	0.56	1
HEXIM2	Physical association	Medium	0.56	38
HGF	Physical association	Medium	0.56	2
HP1BP3	Physical association	Medium	0.56	1
HTR1E	Physical association	Medium	0.56	2
IGFN1	Physical association	Medium	0.56	1
IL1A	Physical association	Medium	0.56	5
IP6K2	Physical association	Medium	0.56	7
ITM2A	Physical association	Medium	0.56	7
KAT5	Physical association	Medium	0.56	180
KIZ	Physical association	Medium	0.56	6
KLC4	Physical association	Medium	0.56	18
KLHL38	Physical association	Medium	0.56	72
KRT80	Physical association	Medium	0.56	3
KRT86	Physical association	Medium	0.56	38
KRTAP10-11	Physical association	Medium	0.56	31
KRTAP10-5	Physical association	Medium	0.56	115
KRTAP10-8	Physical association	Medium	0.56	325
KRTAP12-4	Physical association	Medium	0.56	41
KRTAP4-11	Physical association	Medium	0.56	61
KRTAP4-2	Physical association	Medium	0.56	102
KRTAP4-7	Physical association	Medium	0.56	11
KRTAP5-6	Physical association	Medium	0.56	73
KRTAP5-9	Physical association	Medium	0.56	166
KRTAP9-2	Physical association	Medium	0.56	123
KTN1	Physical association	Medium	0.56	6
LAMTOR5	Physical association	Medium	0.56	17
LCE1B	Physical association	Medium	0.56	69
LCE2A	Physical association	Medium	0.56	43
LCE4A	Physical association	Medium	0.56	63
LSM2	Physical association	Medium	0.56	29
MAGED1	Physical association	Medium	0.56	79
MAPKBP1	Physical association	Medium	0.56	48
MMP3	Physical association	Medium	0.56	1
MORN3	Physical association	Medium	0.56	57
MRFAP1L1	Physical association	Medium	0.56	46
MSI2	Physical association	Medium	0.56	3
NAA10	Physical association	Medium	0.56	41
NALCN	Physical association	Medium	0.56	1
NCALD	Physical association	Medium	0.56	19
NCK2	Physical association	Medium	0.56	113
NTF3	Physical association	Medium	0.56	1
ODAD4	Physical association	Medium	0.56	7
OIT3	Physical association	Medium	0.56	9
OSGIN1	Physical association	Medium	0.56	30
P4HA3	Physical association	Medium	0.56	39
PACSIN2	Physical association	Medium	0.56	10
PAGE2	Physical association	Medium	0.56	2
PARVG	Physical association	Medium	0.56	23
PCSK5	Physical association	Medium	0.56	10
PIN1	Physical association	Medium	0.56	112
PRKAB2	Physical association	Medium	0.56	126
PRR19	Physical association	Medium	0.56	2
PSMB10	Physical association	Medium	0.56	7
PSMC1	Physical association	Medium	0.56	27
PSMD14	Physical association	Medium	0.56	18
RCHY1	Physical association	Medium	0.56	17
RHOJ	Physical association	Medium	0.56	16
RMND5A	Physical association	Medium	0.56	18
RPL15	Physical association	Medium	0.56	6
SCNM1	Physical association	Medium	0.56	148
SET	Physical association	Medium	0.56	13
SHFL	Physical association	Medium	0.56	26
SLC48A1	Physical association	Medium	0.56	6
SMARCE1	Physical association	Medium	0.56	56
SPP1	Physical association	Medium	0.56	7
SPRY2	Physical association	Medium	0.56	51
SSX3	Physical association	Medium	0.56	12
STK16	Physical association	Medium	0.56	66
STX11	Physical association	Medium	0.56	80
STX16	Physical association	Medium	0.56	4
STXBP1	Physical association	Medium	0.56	16
SYT17	Physical association	Medium	0.56	34
TBCEL	Physical association	Medium	0.56	4
TCEA2	Physical association	Medium	0.56	88
TICAM2	Physical association	Medium	0.56	4
TMEM100	Physical association	Medium	0.56	32
TP53BP1	Physical association	Medium	0.56	71
TRAF6	Physical association	Medium	0.56	60
TRIM41	Physical association	Medium	0.56	108
TRIM42	Physical association	Medium	0.56	112
TTC9C	Physical association	Medium	0.56	14
TXLNA	Physical association	Medium	0.56	76
UBL4A	Physical association	Medium	0.56	12
UBL4B	Physical association	Medium	0.56	4
UNC45A	Physical association	Medium	0.56	6
USE1	Physical association	Medium	0.56	17
VDR	Physical association	Medium	0.56	11
WFDC9	Physical association	Medium	0.56	1
XRCC2	Physical association	Medium	0.56	4
ZBED4	Physical association	Medium	0.56	1
ZMAT2	Physical association	Medium	0.56	44
ZNF124	Physical association	Medium	0.56	45
ZNF329	Physical association	Medium	0.56	21
ZNF404	Physical association	Medium	0.56	1
ZNF417	Physical association	Medium	0.56	140
ZNF564	Physical association	Medium	0.56	30
ZNF572	Physical association	Medium	0.56	58
ZNF587	Physical association	Medium	0.56	102
ZNF695	Physical association	Medium	0.56	1
PAX3	Direct interaction	Medium	0.53	3
MDFI	Physical association	Medium	0.49	277
PRPF31	Physical association	Medium	0.49	118
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
MEOX2 is not a metabolic protein