Protein interactions for MDFI - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MDFI
Gene descriptionⁱ Full gene name according to HGNC.	MyoD family inhibitor
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Epithelium - Extracellular exosomes (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enhanced (esophagus)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.49
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nucleoplasm
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Epithelium - Extracellular exosomes

Field

Cluster

Pathway

Number of interactions:

277

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
PRKAB2	Physical association	High	0.88	126
ZNF136	Physical association	High	0.88	6
ZNF440	Physical association	High	0.88	26
OTX1	Physical association	High	0.86	118
ZBTB24	Physical association	High	0.84	52
ENKD1	Physical association	High	0.83	159
ZNF439	Physical association	High	0.83	19
ZNF559	Physical association	High	0.83	8
ZNF581	Physical association	High	0.83	82
AQP1	Physical association	High	0.82	106
C10orf62	Physical association	High	0.82	9
SLC25A10	Physical association	High	0.82	6
NPDC1	Physical association	High	0.8	27
AVPI1	Physical association	High	0.78	29
BAHD1	Physical association	High	0.78	54
CCDC116	Physical association	High	0.78	24
DCANP1	Physical association	High	0.78	3
HEYL	Physical association	High	0.78	5
HTR1B	Physical association	High	0.78	2
PIN1	Physical association	High	0.78	112
PTPMT1	Physical association	High	0.78	25
SPG7	Physical association	High	0.78	17
TUSC2	Physical association	High	0.78	3
WNT11	Physical association	High	0.78	17
ZNF223	Physical association	High	0.78	6
ZNF417	Physical association	High	0.78	140
ZNF490	Physical association	High	0.78	23
C8orf48	Physical association	High	0.76	17
CNNM3	Physical association	High	0.76	59
DCAF8	Physical association	High	0.76	9
HOXB9	Physical association	High	0.76	42
REX1BD	Physical association	High	0.76	13
ZNF408	Physical association	High	0.76	51
METTL17	Physical association	High	0.74	11
ZNF707	Physical association	High	0.74	7
BBS2	Physical association	High	0.74	19
SPRY1	Physical association	High	0.74	59
AANAT	Physical association	High	0.72	3
ADAMTSL3	Physical association	High	0.72	13
BEX1	Physical association	High	0.72	12
CDCA7L	Physical association	High	0.72	52
CEP57L1	Physical association	High	0.72	27
DMRT3	Physical association	High	0.72	65
DOCK2	Physical association	High	0.72	36
ELOA	Physical association	High	0.72	38
FAM161A	Physical association	High	0.72	118
FOXD4L6	Physical association	High	0.72	15
LCE3E	Physical association	High	0.72	46
LCE4A	Physical association	High	0.72	63
MAGED1	Physical association	High	0.72	79
MAPKBP1	Physical association	High	0.72	48
ODAPH	Physical association	High	0.72	3
OLIG3	Physical association	High	0.72	24
PIH1D2	Physical association	High	0.72	64
RIPPLY1	Physical association	High	0.72	28
RTP5	Physical association	High	0.72	49
ZBTB9	Physical association	High	0.72	28
ZNF101	Physical association	High	0.72	7
ZNF124	Physical association	High	0.72	45
ZNF266	Physical association	High	0.72	8
ZNF564	Physical association	High	0.72	30
ZNF587	Physical association	High	0.72	102
ZNF844	Physical association	High	0.72	11
CBFA2T2	Physical association	High	0.71	4
DKK1	Physical association	High	0.71	3
FAM124B	Physical association	High	0.71	24
NEU4	Physical association	High	0.71	3
PBXIP1	Physical association	High	0.71	13
GNAI2	Physical association	High	0.7	10
ARID5A	Physical association	High	0.7	94
C8orf33	Physical association	High	0.7	20
GDF15	Physical association	High	0.7	5
PRPF31	Physical association	High	0.7	118
ZNF670	Physical association	High	0.7	19
ATOSB	Physical association	High	0.67	50
CATSPER1	Physical association	High	0.67	95
CCDC185	Physical association	High	0.67	34
DHRS1	Physical association	High	0.67	25
GATA2	Physical association	High	0.67	24
HNRNPLL	Physical association	High	0.67	8
LCE1B	Physical association	High	0.67	69
MAGEF1	Physical association	High	0.67	1
NECTIN2	Physical association	High	0.67	10
TGIF1	Physical association	High	0.67	12
TNP2	Physical association	High	0.67	7
VHL	Physical association	High	0.67	13
VPS72	Physical association	High	0.67	5
ZNF607	Physical association	High	0.67	2
ZNF679	Physical association	High	0.67	4
ZNF764	Physical association	High	0.67	26
AQP5	Physical association	High	0.62	5
CBX2	Physical association	High	0.62	8
LASP1	Physical association	High	0.62	21
LRCH4	Physical association	High	0.62	14
NR1H2	Physical association	High	0.62	5
PHLDA1	Physical association	High	0.62	4
PIDD1	Physical association	High	0.62	2
THEG	Physical association	High	0.62	5
ZNF646	Physical association	High	0.62	4
BEX2	Physical association	High	0.6	67
LCE3D	Physical association	High	0.6	44
ADRA2C	Physical association	Medium	0.56	10
AGXT	Physical association	Medium	0.56	28
ARHGAP32	Physical association	Medium	0.56	9
ARMC7	Physical association	Medium	0.56	58
ATP5F1D	Physical association	Medium	0.56	7
AXIN1	Physical association	Medium	0.56	40
BAG3	Physical association	Medium	0.56	58
BCAM	Physical association	Medium	0.56	6
BEX3	Physical association	Medium	0.56	25
C1orf216	Physical association	Medium	0.56	69
C22orf39	Physical association	Medium	0.56	36
C4orf45	Physical association	Medium	0.56	16
CBLL2	Physical association	Medium	0.56	7
CBX8	Physical association	Medium	0.56	78
CC2D1B	Physical association	Medium	0.56	1
CCDC198	Physical association	Medium	0.56	16
CDC37	Physical association	Medium	0.56	124
CDKL3	Physical association	Medium	0.56	22
CHP2	Physical association	Medium	0.56	2
CRACR2A	Physical association	Medium	0.56	31
CRH	Physical association	Medium	0.56	11
CTRC	Physical association	Medium	0.56	12
DCAF6	Physical association	Medium	0.56	2
DNAJB13	Physical association	Medium	0.56	9
DNMT3A	Physical association	Medium	0.56	14
DYNLT4	Physical association	Medium	0.56	1
EFEMP2	Physical association	Medium	0.56	83
FAM120AOS	Physical association	Medium	0.56	1
FAM161B	Physical association	Medium	0.56	54
FAM90A1	Physical association	Medium	0.56	128
FARS2	Physical association	Medium	0.56	56
FBXO34	Physical association	Medium	0.56	18
FEZF1	Physical association	Medium	0.56	6
FNDC11	Physical association	Medium	0.56	37
FOXD4	Physical association	Medium	0.56	4
FOXD4L1	Physical association	Medium	0.56	17
FOXD4L3	Physical association	Medium	0.56	14
GABRD	Physical association	Medium	0.56	3
GNG5	Physical association	Medium	0.56	6
GPANK1	Physical association	Medium	0.56	65
GPATCH2L	Physical association	Medium	0.56	19
GREM1	Physical association	Medium	0.56	4
GTF3C5	Physical association	Medium	0.56	6
HAPLN2	Physical association	Medium	0.56	36
HASPIN	Physical association	Medium	0.56	3
HHEX	Physical association	Medium	0.56	23
HPCAL1	Physical association	Medium	0.56	31
IQUB	Physical association	Medium	0.56	56
JOSD1	Physical association	Medium	0.56	24
KAT5	Physical association	Medium	0.56	180
KLHL38	Physical association	Medium	0.56	72
KPNA2	Physical association	Medium	0.56	32
KRT77	Physical association	Medium	0.56	6
LCE1A	Physical association	Medium	0.56	59
LCE1D	Physical association	Medium	0.56	47
LCE1F	Physical association	Medium	0.56	61
LCE2B	Physical association	Medium	0.56	55
LCE3A	Physical association	Medium	0.56	54
LCE3C	Physical association	Medium	0.56	46
LIN7A	Physical association	Medium	0.56	12
MAPK1	Physical association	Medium	0.56	33
MBD3L2	Physical association	Medium	0.56	7
MYPOP	Physical association	Medium	0.56	33
NIBAN3	Physical association	Medium	0.56	2
NKD1	Physical association	Medium	0.56	11
NR1H3	Physical association	Medium	0.56	10
NUBP2	Physical association	Medium	0.56	10
NUFIP2	Physical association	Medium	0.56	58
ODF1	Physical association	Medium	0.56	7
ODF3B	Physical association	Medium	0.56	8
PDIA5	Physical association	Medium	0.56	2
PELI2	Physical association	Medium	0.56	17
PHF1	Physical association	Medium	0.56	45
PID1	Physical association	Medium	0.56	9
PITX1	Physical association	Medium	0.56	50
PKD2	Physical association	Medium	0.56	12
PLEKHG4	Physical association	Medium	0.56	50
PRPF18	Physical association	Medium	0.56	63
PTK7	Physical association	Medium	0.56	6
RAC1	Physical association	Medium	0.56	59
RASD1	Physical association	Medium	0.56	23
REG3A	Physical association	Medium	0.56	1
RHOXF2	Physical association	Medium	0.56	52
RIN1	Physical association	Medium	0.56	38
SAPCD2	Physical association	Medium	0.56	11
SCAMP4	Physical association	Medium	0.56	16
SCNM1	Physical association	Medium	0.56	148
SELENOM	Physical association	Medium	0.56	10
SHFL	Physical association	Medium	0.56	26
SHMT1	Physical association	Medium	0.56	6
SLC13A5	Physical association	Medium	0.56	16
SLC15A3	Physical association	Medium	0.56	5
SMYD1	Physical association	Medium	0.56	24
SNX18	Physical association	Medium	0.56	14
SOCS7	Physical association	Medium	0.56	12
SPON1	Physical association	Medium	0.56	2
SPRED2	Physical association	Medium	0.56	38
SPRY2	Physical association	Medium	0.56	51
SUOX	Physical association	Medium	0.56	67
TACO1	Physical association	Medium	0.56	15
TASOR2	Physical association	Medium	0.56	34
TBC1D3G	Physical association	Medium	0.56	8
TEDC2	Physical association	Medium	0.56	6
TNNI1	Physical association	Medium	0.56	29
TOR1A	Physical association	Medium	0.56	8
TRIB3	Physical association	Medium	0.56	54
TSFM	Physical association	Medium	0.56	8
TSGA10IP	Physical association	Medium	0.56	83
TSPAN4	Physical association	Medium	0.56	30
TSPYL6	Physical association	Medium	0.56	9
TTC23	Physical association	Medium	0.56	17
TTLL10	Physical association	Medium	0.56	10
TXN2	Physical association	Medium	0.56	60
TYRO3	Physical association	Medium	0.56	13
USP20	Physical association	Medium	0.56	10
VASN	Physical association	Medium	0.56	42
VSTM4	Physical association	Medium	0.56	8
YY1	Physical association	Medium	0.56	47
ZBTB42	Physical association	Medium	0.56	38
ZC3HAV1	Physical association	Medium	0.56	3
ZDHHC1	Physical association	Medium	0.56	14
ZIM2	Physical association	Medium	0.56	26
ZNF12	Physical association	Medium	0.56	5
ZNF138	Physical association	Medium	0.56	16
ZNF155	Physical association	Medium	0.56	4
ZNF221	Physical association	Medium	0.56	3
ZNF23	Physical association	Medium	0.56	14
ZNF230	Physical association	Medium	0.56	6
ZNF264	Physical association	Medium	0.56	14
ZNF330	Physical association	Medium	0.56	43
ZNF414	Physical association	Medium	0.56	42
ZNF433	Physical association	Medium	0.56	5
ZNF438	Physical association	Medium	0.56	50
ZNF441	Physical association	Medium	0.56	7
ZNF461	Physical association	Medium	0.56	1
ZNF479	Physical association	Medium	0.56	5
ZNF491	Physical association	Medium	0.56	8
ZNF497	Physical association	Medium	0.56	41
ZNF512B	Physical association	Medium	0.56	10
ZNF524	Physical association	Medium	0.56	22
ZNF572	Physical association	Medium	0.56	58
ZNF575	Physical association	Medium	0.56	22
ZNF578	Physical association	Medium	0.56	12
ZNF580	Physical association	Medium	0.56	15
ZNF613	Physical association	Medium	0.56	4
ZNF648	Physical association	Medium	0.56	50
ZNF669	Physical association	Medium	0.56	15
ZNF696	Physical association	Medium	0.56	30
ZNF784	Physical association	Medium	0.56	6
ZNF785	Physical association	Medium	0.56	13
ZNF786	Physical association	Medium	0.56	9
ZNF79	Physical association	Medium	0.56	6
ZNF837	Physical association	Medium	0.56	68
ZNHIT1	Physical association	Medium	0.56	22
CCDC120	Physical association	Medium	0.55	90
THAP7	Physical association	Medium	0.55	47
RABL6	Physical association	Medium	0.51	2
SIX1	Physical association	Medium	0.51	7
ZBTB25	Physical association	Medium	0.51	24
APLN	Physical association	Medium	0.49	1
B3GNT9	Physical association	Medium	0.49	1
BCL6	Physical association	Medium	0.49	40
CDC42EP1	Physical association	Medium	0.49	4
CLPB	Physical association	Medium	0.49	2
CYBA	Physical association	Medium	0.49	3
DBF4B	Physical association	Medium	0.49	2
EIF4E2	Physical association	Medium	0.49	32
ETNK2	Physical association	Medium	0.49	4
FES	Physical association	Medium	0.49	4
GLRX3	Physical association	Medium	0.49	78
MACIR	Physical association	Medium	0.49	6
MEOX2	Physical association	Medium	0.49	158
NDUFA7	Physical association	Medium	0.49	4
PDGFB	Physical association	Medium	0.49	4
TIE1	Physical association	Medium	0.49	7
USP6	Physical association	Medium	0.49	1
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
MDFI is not a metabolic protein