Protein interactions for KRTAP10-8 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	KRTAP10-8
Gene descriptionⁱ Full gene name according to HGNC.	Keratin associated protein 10-8
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Skin - Keratinization (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enriched (skin)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	1.00
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in single
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Not available
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Skin - Keratinization

Field

Cluster

Pathway

Number of interactions:

325

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
PRPF31	Physical association	High	0.81	118
LCE1B	Physical association	High	0.78	69
ADAMTSL3	Physical association	High	0.72	13
ALDH3B1	Physical association	High	0.72	15
BEX2	Physical association	High	0.72	67
C11orf87	Physical association	High	0.72	18
CARHSP1	Physical association	High	0.72	11
CATSPER1	Physical association	High	0.72	95
CHIC2	Physical association	High	0.72	53
CHRD	Physical association	High	0.72	40
CNNM3	Physical association	High	0.72	59
COL8A1	Physical association	High	0.72	51
CRCT1	Physical association	High	0.72	46
DDX6	Physical association	High	0.72	66
DHRS1	Physical association	High	0.72	25
DHX57	Physical association	High	0.72	18
DMRT3	Physical association	High	0.72	65
DOCK2	Physical association	High	0.72	36
FBXW5	Physical association	High	0.72	21
GLRX3	Physical association	High	0.72	78
HHEX	Physical association	High	0.72	23
HPCAL1	Physical association	High	0.72	31
HSD3B7	Physical association	High	0.72	42
IGSF8	Physical association	High	0.72	9
JOSD1	Physical association	High	0.72	24
KLHL38	Physical association	High	0.72	72
KRT20	Physical association	High	0.72	32
KRTAP10-7	Physical association	High	0.72	239
KRTAP10-9	Physical association	High	0.72	182
KRTAP12-1	Physical association	High	0.72	50
KRTAP4-11	Physical association	High	0.72	61
KRTAP4-12	Physical association	High	0.72	74
KRTAP4-2	Physical association	High	0.72	102
KRTAP5-6	Physical association	High	0.72	73
KRTAP5-9	Physical association	High	0.72	166
KRTAP9-2	Physical association	High	0.72	123
LCE2A	Physical association	High	0.72	43
LCE2D	Physical association	High	0.72	51
LCE3C	Physical association	High	0.72	46
LCE3E	Physical association	High	0.72	46
LCE4A	Physical association	High	0.72	63
MAPKBP1	Physical association	High	0.72	48
NAXD	Physical association	High	0.72	13
NUFIP2	Physical association	High	0.72	58
OTX1	Physical association	High	0.72	118
PRKAB2	Physical association	High	0.72	126
PRR13	Physical association	High	0.72	37
PTPMT1	Physical association	High	0.72	25
PVR	Physical association	High	0.72	52
SCNM1	Physical association	High	0.72	148
SLC6A20	Physical association	High	0.72	8
SMCP	Physical association	High	0.72	67
SPRY1	Physical association	High	0.72	59
STK16	Physical association	High	0.72	66
SUSD6	Physical association	High	0.72	7
THAP7	Physical association	High	0.72	47
UTP23	Physical association	High	0.72	22
UXT	Physical association	High	0.72	21
WIF1	Physical association	High	0.72	4
ZBTB24	Physical association	High	0.72	52
ZNF124	Physical association	High	0.72	45
ZNF20	Physical association	High	0.72	43
ZNF417	Physical association	High	0.72	140
ZNF439	Physical association	High	0.72	19
ZNF473	Physical association	High	0.72	17
ZNF572	Physical association	High	0.72	58
ZNF587	Physical association	High	0.72	102
ZSCAN21	Physical association	High	0.72	22
CCNJL	Physical association	High	0.67	8
CHRNG	Physical association	High	0.67	5
SLC23A1	Physical association	High	0.67	10
ACY3	Physical association	High	0.62	15
KRTAP4-4	Physical association	High	0.6	56
ADAMTS1	Physical association	Medium	0.56	3
AEN	Physical association	Medium	0.56	27
AK3	Physical association	Medium	0.56	8
ALPI	Physical association	Medium	0.56	3
ALPP	Physical association	Medium	0.56	30
AMMECR1	Physical association	Medium	0.56	7
AP1M1	Physical association	Medium	0.56	67
APOL6	Physical association	Medium	0.56	7
AQP1	Physical association	Medium	0.56	106
AREG	Physical association	Medium	0.56	3
ARID5A	Physical association	Medium	0.56	94
ASPSCR1	Physical association	Medium	0.56	9
ATG9A	Physical association	Medium	0.56	11
ATP5F1D	Physical association	Medium	0.56	7
AVPI1	Physical association	Medium	0.56	29
AXIN2	Physical association	Medium	0.56	36
BAHD1	Physical association	Medium	0.56	54
BMP7	Physical association	Medium	0.56	13
C10orf62	Physical association	Medium	0.56	9
C17orf50	Physical association	Medium	0.56	6
C19orf25	Physical association	Medium	0.56	18
C22orf39	Physical association	Medium	0.56	36
C2orf68	Physical association	Medium	0.56	11
C3	Physical association	Medium	0.56	9
CAMK1G	Physical association	Medium	0.56	4
CARD10	Physical association	Medium	0.56	83
CLK4	Physical association	Medium	0.56	6
COX17	Physical association	Medium	0.56	4
CRH	Physical association	Medium	0.56	11
CRY2	Physical association	Medium	0.56	29
CSF1	Physical association	Medium	0.56	7
CTRC	Physical association	Medium	0.56	12
CYP2S1	Physical association	Medium	0.56	2
CYSRT1	Physical association	Medium	0.56	396
DCX	Physical association	Medium	0.56	13
DDX43	Physical association	Medium	0.56	2
DDX55	Physical association	Medium	0.56	3
DERL2	Physical association	Medium	0.56	8
ECE1	Physical association	Medium	0.56	5
EFEMP2	Physical association	Medium	0.56	83
EIF4E2	Physical association	Medium	0.56	32
ENKD1	Physical association	Medium	0.56	159
EPDR1	Physical association	Medium	0.56	10
FAH	Physical association	Medium	0.56	6
FAM110A	Physical association	Medium	0.56	41
FAM161A	Physical association	Medium	0.56	118
FAM221B	Physical association	Medium	0.56	12
FAM76B	Physical association	Medium	0.56	8
FAM90A1	Physical association	Medium	0.56	128
FARS2	Physical association	Medium	0.56	56
FBXO34	Physical association	Medium	0.56	18
FEZF1	Physical association	Medium	0.56	6
FOXB1	Physical association	Medium	0.56	5
FRS3	Physical association	Medium	0.56	77
FTHL17	Physical association	Medium	0.56	3
FZD10	Physical association	Medium	0.56	6
GARIN6	Physical association	Medium	0.56	19
GEM	Physical association	Medium	0.56	88
GFOD1	Physical association	Medium	0.56	17
GLP1R	Physical association	Medium	0.56	10
GLYAT	Physical association	Medium	0.56	2
GNAI2	Physical association	Medium	0.56	10
GNE	Physical association	Medium	0.56	12
GPANK1	Physical association	Medium	0.56	65
GPHB5	Physical association	Medium	0.56	7
GRN	Physical association	Medium	0.56	216
HAPLN2	Physical association	Medium	0.56	36
HOXB5	Physical association	Medium	0.56	47
HOXB9	Physical association	Medium	0.56	42
HOXC8	Physical association	Medium	0.56	74
HS6ST1	Physical association	Medium	0.56	2
HSPA12B	Physical association	Medium	0.56	10
HSPD1	Physical association	Medium	0.56	35
ICAM1	Physical association	Medium	0.56	7
IGFBP6	Physical association	Medium	0.56	28
IL10	Physical association	Medium	0.56	8
IL2RG	Physical association	Medium	0.56	6
INO80B	Physical association	Medium	0.56	49
INTS5	Physical association	Medium	0.56	2
IP6K3	Physical association	Medium	0.56	13
ITGB2	Physical association	Medium	0.56	21
ITGB5	Physical association	Medium	0.56	20
JPH3	Physical association	Medium	0.56	146
KLK8	Physical association	Medium	0.56	13
KPRP	Physical association	Medium	0.56	80
KRT83	Physical association	Medium	0.56	31
KRTAP1-1	Physical association	Medium	0.56	150
KRTAP1-3	Physical association	Medium	0.56	140
KRTAP10-10	Physical association	Medium	0.56	18
KRTAP10-11	Physical association	Medium	0.56	31
KRTAP10-5	Physical association	Medium	0.56	115
KRTAP11-1	Physical association	Medium	0.56	83
KRTAP12-2	Physical association	Medium	0.56	97
KRTAP12-3	Physical association	Medium	0.56	117
KRTAP15-1	Physical association	Medium	0.56	53
KRTAP17-1	Physical association	Medium	0.56	41
KRTAP19-7	Physical association	Medium	0.56	71
KRTAP3-1	Physical association	Medium	0.56	61
KRTAP3-2	Physical association	Medium	0.56	54
KRTAP4-5	Physical association	Medium	0.56	54
KRTAP4-7	Physical association	Medium	0.56	11
KRTAP5-11	Physical association	Medium	0.56	49
KRTAP5-2	Physical association	Medium	0.56	38
KRTAP5-3	Physical association	Medium	0.56	39
KRTAP9-3	Physical association	Medium	0.56	103
KRTAP9-4	Physical association	Medium	0.56	25
KRTAP9-8	Physical association	Medium	0.56	72
LAGE3	Physical association	Medium	0.56	19
LCE1A	Physical association	Medium	0.56	59
LCE1C	Physical association	Medium	0.56	55
LCE1D	Physical association	Medium	0.56	47
LCE1E	Physical association	Medium	0.56	52
LCE1F	Physical association	Medium	0.56	61
LCE2B	Physical association	Medium	0.56	55
LCE2C	Physical association	Medium	0.56	71
LCE3A	Physical association	Medium	0.56	54
LCE3B	Physical association	Medium	0.56	34
LCE3D	Physical association	Medium	0.56	44
LCE5A	Physical association	Medium	0.56	53
LELP1	Physical association	Medium	0.56	14
LENG1	Physical association	Medium	0.56	63
LNX1	Physical association	Medium	0.56	333
LRCH4	Physical association	Medium	0.56	14
LRFN4	Physical association	Medium	0.56	8
LUZP4	Physical association	Medium	0.56	19
LYVE1	Physical association	Medium	0.56	21
MACROH2A1	Physical association	Medium	0.56	11
MATN3	Physical association	Medium	0.56	5
MEOX2	Physical association	Medium	0.56	158
MOBP	Physical association	Medium	0.56	5
MTA1	Physical association	Medium	0.56	23
MUL1	Physical association	Medium	0.56	4
MYPOP	Physical association	Medium	0.56	33
NAB2	Physical association	Medium	0.56	62
NECTIN3	Physical association	Medium	0.56	9
NKD1	Physical association	Medium	0.56	11
NOTCH2NLA	Physical association	Medium	0.56	190
NOTCH2NLC	Physical association	Medium	0.56	178
NPDC1	Physical association	Medium	0.56	27
NR4A3	Physical association	Medium	0.56	30
NTN4	Physical association	Medium	0.56	8
OLIG3	Physical association	Medium	0.56	24
OPCML	Physical association	Medium	0.56	3
P2RX7	Physical association	Medium	0.56	10
P2RY6	Physical association	Medium	0.56	15
PAX5	Physical association	Medium	0.56	33
PCED1A	Physical association	Medium	0.56	3
PCSK5	Physical association	Medium	0.56	10
PDE9A	Physical association	Medium	0.56	14
PDIA4	Physical association	Medium	0.56	7
PGAP6	Physical association	Medium	0.56	9
PIGS	Physical association	Medium	0.56	11
PIN1	Physical association	Medium	0.56	112
PKD2	Physical association	Medium	0.56	12
PLSCR4	Physical association	Medium	0.56	45
POU1F1	Physical association	Medium	0.56	9
POU4F2	Physical association	Medium	0.56	62
PTK7	Physical association	Medium	0.56	6
PTPRH	Physical association	Medium	0.56	4
QPRT	Physical association	Medium	0.56	2
R3HDM2	Physical association	Medium	0.56	15
RAB19	Physical association	Medium	0.56	3
RAB3A	Physical association	Medium	0.56	6
RASD1	Physical association	Medium	0.56	23
RGL2	Physical association	Medium	0.56	6
RHBDL1	Physical association	Medium	0.56	8
RHNO1	Physical association	Medium	0.56	7
RNF38	Physical association	Medium	0.56	11
RNF8	Physical association	Medium	0.56	41
RPS19BP1	Physical association	Medium	0.56	8
RPS28	Physical association	Medium	0.56	9
RTN4RL1	Physical association	Medium	0.56	5
SCARF1	Physical association	Medium	0.56	18
SH3GLB2	Physical association	Medium	0.56	19
SHFL	Physical association	Medium	0.56	26
SLC13A5	Physical association	Medium	0.56	16
SLC22A23	Physical association	Medium	0.56	3
SLC25A10	Physical association	Medium	0.56	6
SLC25A31	Physical association	Medium	0.56	1
SLC25A42	Physical association	Medium	0.56	3
SLIT1	Physical association	Medium	0.56	8
SMARCE1	Physical association	Medium	0.56	56
SMG9	Physical association	Medium	0.56	32
SMOC1	Physical association	Medium	0.56	3
SPACA9	Physical association	Medium	0.56	7
SPRY2	Physical association	Medium	0.56	51
SUSD2	Physical association	Medium	0.56	2
SUV39H1	Physical association	Medium	0.56	52
TACSTD2	Physical association	Medium	0.56	4
TAPBPL	Physical association	Medium	0.56	8
TBC1D23	Physical association	Medium	0.56	7
TCEA2	Physical association	Medium	0.56	88
TFAP2D	Physical association	Medium	0.56	48
THAP10	Physical association	Medium	0.56	11
TIE1	Physical association	Medium	0.56	7
TLE5	Physical association	Medium	0.56	105
TMEM140	Physical association	Medium	0.56	44
TMEM150A	Physical association	Medium	0.56	4
TNIP3	Physical association	Medium	0.56	26
TNP2	Physical association	Medium	0.56	7
TNPO3	Physical association	Medium	0.56	9
TNS2	Physical association	Medium	0.56	70
TRIM41	Physical association	Medium	0.56	108
TRIM42	Physical association	Medium	0.56	112
TSPAN4	Physical association	Medium	0.56	30
TYRO3	Physical association	Medium	0.56	13
UBL5	Physical association	Medium	0.56	28
VASN	Physical association	Medium	0.56	42
VENTX	Physical association	Medium	0.56	60
VEZF1	Physical association	Medium	0.56	40
VWC2	Physical association	Medium	0.56	51
VWC2L	Physical association	Medium	0.56	20
WNT11	Physical association	Medium	0.56	17
WT1	Physical association	Medium	0.56	4
YIPF3	Physical association	Medium	0.56	13
YY1	Physical association	Medium	0.56	47
ZBTB25	Physical association	Medium	0.56	24
ZDHHC1	Physical association	Medium	0.56	14
ZFYVE21	Physical association	Medium	0.56	22
ZIC1	Physical association	Medium	0.56	55
ZNF101	Physical association	Medium	0.56	7
ZNF107	Physical association	Medium	0.56	1
ZNF121	Physical association	Medium	0.56	7
ZNF138	Physical association	Medium	0.56	16
ZNF165	Physical association	Medium	0.56	31
ZNF23	Physical association	Medium	0.56	14
ZNF264	Physical association	Medium	0.56	14
ZNF266	Physical association	Medium	0.56	8
ZNF319	Physical association	Medium	0.56	17
ZNF32	Physical association	Medium	0.56	9
ZNF330	Physical association	Medium	0.56	43
ZNF408	Physical association	Medium	0.56	51
ZNF414	Physical association	Medium	0.56	42
ZNF440	Physical association	Medium	0.56	26
ZNF490	Physical association	Medium	0.56	23
ZNF491	Physical association	Medium	0.56	8
ZNF497	Physical association	Medium	0.56	41
ZNF524	Physical association	Medium	0.56	22
ZNF559	Physical association	Medium	0.56	8
ZNF575	Physical association	Medium	0.56	22
ZNF578	Physical association	Medium	0.56	12
ZNF580	Physical association	Medium	0.56	15
ZNF581	Physical association	Medium	0.56	82
ZNF648	Physical association	Medium	0.56	50
ZNF669	Physical association	Medium	0.56	15
ZNF696	Physical association	Medium	0.56	30
ZNF775	Physical association	Medium	0.56	9
ZNF786	Physical association	Medium	0.56	9
ZNF79	Physical association	Medium	0.56	6
ZNF792	Physical association	Medium	0.56	46
ZNF837	Physical association	Medium	0.56	68
ZSCAN12	Physical association	Medium	0.56	20
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
KRTAP10-8 is not a metabolic protein