Protein interactions for JPH3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	JPH3
Gene descriptionⁱ Full gene name according to HGNC.	Junctophilin 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Brain - Neuronal signaling (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enriched (brain)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.93
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nucleoplasm In addition localized to the Cytosol
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Brain - Neuronal signaling

Field

Cluster

Pathway

Number of interactions:

146

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
AK3	Physical association	Medium	0.56	8
ALDH1A1	Physical association	Medium	0.56	4
ASB9	Physical association	Medium	0.56	15
ATL1	Physical association	Medium	0.56	17
ATP6V1B2	Physical association	Medium	0.56	7
BAK1	Physical association	Medium	0.56	18
BCAS2	Physical association	Medium	0.56	49
BGN	Physical association	Medium	0.56	3
BIRC2	Physical association	Medium	0.56	30
BRK1	Physical association	Medium	0.56	46
BTRC	Physical association	Medium	0.56	37
C20orf141	Physical association	Medium	0.56	4
C6orf141	Physical association	Medium	0.56	8
CCL21	Physical association	Medium	0.56	8
CD1C	Physical association	Medium	0.56	2
CDC23	Physical association	Medium	0.56	69
CENPV	Physical association	Medium	0.56	14
CKMT1A	Physical association	Medium	0.56	10
CKMT1B	Physical association	Medium	0.56	10
CLPP	Physical association	Medium	0.56	19
CRLF3	Physical association	Medium	0.56	24
CTNNB1	Physical association	Medium	0.56	81
CWF19L2	Physical association	Medium	0.56	65
CYP26B1	Physical association	Medium	0.56	1
DDIT3	Physical association	Medium	0.56	30
DES	Physical association	Medium	0.56	36
DRG2	Physical association	Medium	0.56	7
DUSP18	Physical association	Medium	0.56	2
DVL3	Physical association	Medium	0.56	120
EGFL8	Physical association	Medium	0.56	8
EIF3F	Physical association	Medium	0.56	42
ESS2	Physical association	Medium	0.56	10
ETFRF1	Physical association	Medium	0.56	3
EXTL2	Physical association	Medium	0.56	3
FANCG	Physical association	Medium	0.56	35
FASTKD1	Physical association	Medium	0.56	9
FBXO15	Physical association	Medium	0.56	1
GFAP	Physical association	Medium	0.56	147
GJA5	Physical association	Medium	0.56	27
GMCL2	Physical association	Medium	0.56	22
H3C13	Physical association	Medium	0.56	27
H3C14	Physical association	Medium	0.56	27
H3C15	Physical association	Medium	0.56	27
HNRNPK	Physical association	Medium	0.56	49
HSFY1	Physical association	Medium	0.56	16
HSFY2	Physical association	Medium	0.56	16
IL22RA1	Physical association	Medium	0.56	2
IQUB	Physical association	Medium	0.56	56
KIAA0408	Physical association	Medium	0.56	24
KRT19	Physical association	Medium	0.56	65
KRTAP10-8	Physical association	Medium	0.56	325
LENG8	Physical association	Medium	0.56	35
LGALS9C	Physical association	Medium	0.56	23
LIX1	Physical association	Medium	0.56	4
LNX1	Physical association	Medium	0.56	333
LONRF2	Physical association	Medium	0.56	12
LPIN1	Physical association	Medium	0.56	18
LZIC	Physical association	Medium	0.56	3
MAGEB3	Physical association	Medium	0.56	1
MARCHF10	Physical association	Medium	0.56	5
MICAL2	Physical association	Medium	0.56	8
MLC1	Physical association	Medium	0.56	13
MPND	Physical association	Medium	0.56	15
MRPL49	Physical association	Medium	0.56	2
MSRB2	Physical association	Medium	0.56	9
MYBPHL	Physical association	Medium	0.56	10
MYL11	Physical association	Medium	0.56	5
MYNN	Physical association	Medium	0.56	12
NAP1L3	Physical association	Medium	0.56	5
NDUFS7	Physical association	Medium	0.56	1
NME5	Physical association	Medium	0.56	5
NOL6	Physical association	Medium	0.56	1
NYX	Physical association	Medium	0.56	2
ODF3L2	Physical association	Medium	0.56	10
OTUB1	Physical association	Medium	0.56	43
OTX1	Physical association	Medium	0.56	118
PABPC3	Physical association	Medium	0.56	3
PCMTD2	Physical association	Medium	0.56	8
PCSK7	Physical association	Medium	0.56	9
PDLIM5	Physical association	Medium	0.56	9
PER1	Physical association	Medium	0.56	21
PERP	Physical association	Medium	0.56	7
PHOSPHO2	Physical association	Medium	0.56	7
PIWIL1	Physical association	Medium	0.56	5
PMP22	Physical association	Medium	0.56	52
PNO1	Physical association	Medium	0.56	3
PPARA	Physical association	Medium	0.56	18
PPP1R16A	Physical association	Medium	0.56	35
PSME1	Physical association	Medium	0.56	7
PTGR1	Physical association	Medium	0.56	1
RAB35	Physical association	Medium	0.56	3
RAB38	Physical association	Medium	0.56	9
RASSF2	Physical association	Medium	0.56	15
RBM11	Physical association	Medium	0.56	24
RHOBTB3	Physical association	Medium	0.56	9
RNF138	Physical association	Medium	0.56	18
RPS5	Physical association	Medium	0.56	4
SEM1	Physical association	Medium	0.56	11
SF3A3	Physical association	Medium	0.56	7
SFRP4	Physical association	Medium	0.56	3
SKIC8	Physical association	Medium	0.56	30
SLC44A5	Physical association	Medium	0.56	8
SLU7	Physical association	Medium	0.56	22
SMAD3	Physical association	Medium	0.56	52
SMARCB1	Physical association	Medium	0.56	33
SMARCD1	Physical association	Medium	0.56	104
SNW1	Physical association	Medium	0.56	89
SOCS4	Physical association	Medium	0.56	14
SPATA22	Physical association	Medium	0.56	16
SPATA2L	Physical association	Medium	0.56	16
SPRED1	Physical association	Medium	0.56	308
SRSF4	Physical association	Medium	0.56	4
STAMBP	Physical association	Medium	0.56	21
STK3	Physical association	Medium	0.56	24
TAC3	Physical association	Medium	0.56	1
TASOR2	Physical association	Medium	0.56	34
TCAP	Physical association	Medium	0.56	34
TCN1	Physical association	Medium	0.56	1
TMC6	Physical association	Medium	0.56	4
TMED10	Physical association	Medium	0.56	8
TMEM141	Physical association	Medium	0.56	3
TMEM186	Physical association	Medium	0.56	4
TMUB1	Physical association	Medium	0.56	7
TNFAIP1	Physical association	Medium	0.56	31
TRAIP	Physical association	Medium	0.56	8
TTC19	Physical association	Medium	0.56	33
TXN	Physical association	Medium	0.56	26
UBQLNL	Physical association	Medium	0.56	8
USP10	Physical association	Medium	0.56	8
UTP14A	Physical association	Medium	0.56	15
VPS37A	Physical association	Medium	0.56	18
VSX2	Physical association	Medium	0.56	20
WDR83	Physical association	Medium	0.56	30
WWP2	Physical association	Medium	0.56	51
YIPF1	Physical association	Medium	0.56	30
ZBTB25	Physical association	Medium	0.56	24
ZFP36	Physical association	Medium	0.56	6
ZKSCAN3	Physical association	Medium	0.56	12
ZNF19	Physical association	Medium	0.56	23
ZNF20	Physical association	Medium	0.56	43
ZNF232	Physical association	Medium	0.56	21
ZNF436	Physical association	Medium	0.56	19
ZNF500	Physical association	Medium	0.56	8
ZNF581	Physical association	Medium	0.56	82
ZNF774	Physical association	Medium	0.56	68
ZSCAN9	Physical association	Medium	0.56	21
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
JPH3 is not a metabolic protein