Protein interactions for KRTAP12-2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	KRTAP12-2
Gene descriptionⁱ Full gene name according to HGNC.	Keratin associated protein 12-2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Skin - Keratinization (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enriched (skin)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.99
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in single
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Not available
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

Highlight:

Off

Subcell location

Predicted location

Tissue specificity

Protein class

Filter menu »

e.g. Brain enriched, Localized to mitochondria, Skin - Keratinization

Field

Cluster

Pathway

Number of interactions:

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
FHL3	Physical association	High	0.72	103
KRTAP26-1	Physical association	High	0.72	73
KRTAP5-9	Physical association	High	0.72	166
OTX1	Physical association	High	0.72	118
TNS2	Physical association	High	0.72	70
VENTX	Physical association	High	0.72	60
ZBTB9	Physical association	High	0.72	28
ARID5A	Physical association	High	0.7	94
AVPI1	Physical association	High	0.67	29
KRTAP12-1	Physical association	High	0.6	50
SLC15A3	Physical association	High	0.6	5
BEX2	Physical association	Medium	0.56	67
CATSPER1	Physical association	Medium	0.56	95
CBLL2	Physical association	Medium	0.56	7
CCNL1	Physical association	Medium	0.56	16
CFP	Physical association	Medium	0.56	22
CHRD	Physical association	Medium	0.56	40
CNNM3	Physical association	Medium	0.56	59
CYSRT1	Physical association	Medium	0.56	396
DGCR6	Physical association	Medium	0.56	6
DHRS1	Physical association	Medium	0.56	25
EFEMP2	Physical association	Medium	0.56	83
ETNK2	Physical association	Medium	0.56	4
FOXD4	Physical association	Medium	0.56	4
FOXD4L1	Physical association	Medium	0.56	17
FOXD4L3	Physical association	Medium	0.56	14
GDF15	Physical association	Medium	0.56	5
GPANK1	Physical association	Medium	0.56	65
GREM1	Physical association	Medium	0.56	4
HOXB9	Physical association	Medium	0.56	42
HSFX1	Physical association	Medium	0.56	8
HSFX2	Physical association	Medium	0.56	8
INO80B	Physical association	Medium	0.56	49
IQUB	Physical association	Medium	0.56	56
KRT34	Physical association	Medium	0.56	201
KRTAP10-5	Physical association	Medium	0.56	115
KRTAP10-8	Physical association	Medium	0.56	325
KRTAP12-4	Physical association	Medium	0.56	41
KRTAP13-2	Physical association	Medium	0.56	57
KRTAP15-1	Physical association	Medium	0.56	53
KRTAP19-2	Physical association	Medium	0.56	32
KRTAP21-2	Physical association	Medium	0.56	25
KRTAP3-2	Physical association	Medium	0.56	54
KRTAP4-2	Physical association	Medium	0.56	102
KRTAP6-2	Physical association	Medium	0.56	136
KRTAP9-3	Physical association	Medium	0.56	103
KRTAP9-8	Physical association	Medium	0.56	72
LCE1A	Physical association	Medium	0.56	59
LCE1C	Physical association	Medium	0.56	55
LCE1F	Physical association	Medium	0.56	61
LCE2A	Physical association	Medium	0.56	43
LCE2B	Physical association	Medium	0.56	55
LCE4A	Physical association	Medium	0.56	63
MYOZ1	Physical association	Medium	0.56	28
MYPOP	Physical association	Medium	0.56	33
NOTCH2NLA	Physical association	Medium	0.56	190
NOTCH2NLC	Physical association	Medium	0.56	178
NPDC1	Physical association	Medium	0.56	27
ODF1	Physical association	Medium	0.56	7
PACSIN3	Physical association	Medium	0.56	13
PELO	Physical association	Medium	0.56	20
PIH1D2	Physical association	Medium	0.56	64
POLR1C	Physical association	Medium	0.56	87
POU4F2	Physical association	Medium	0.56	62
RAD23A	Physical association	Medium	0.56	41
RBM39	Physical association	Medium	0.56	23
RBPMS	Physical association	Medium	0.56	105
RBX1	Physical association	Medium	0.56	13
RHOXF2	Physical association	Medium	0.56	52
SLC12A4	Physical association	Medium	0.56	8
SLC13A5	Physical association	Medium	0.56	16
SLC15A2	Physical association	Medium	0.56	20
SPRED2	Physical association	Medium	0.56	38
SPRY1	Physical association	Medium	0.56	59
TCEA2	Physical association	Medium	0.56	88
TEX37	Physical association	Medium	0.56	32
TINAGL1	Physical association	Medium	0.56	4
TMEM179B	Physical association	Medium	0.56	45
TRIM42	Physical association	Medium	0.56	112
TRIP13	Physical association	Medium	0.56	71
TSGA10IP	Physical association	Medium	0.56	83
TTPA	Physical association	Medium	0.56	36
VASN	Physical association	Medium	0.56	42
YIPF3	Physical association	Medium	0.56	13
YY1	Physical association	Medium	0.56	47
ZDHHC1	Physical association	Medium	0.56	14
ZIM2	Physical association	Medium	0.56	26
ZNF100	Physical association	Medium	0.56	1
ZNF408	Physical association	Medium	0.56	51
ZNF497	Physical association	Medium	0.56	41
ZNF581	Physical association	Medium	0.56	82
ZNF587	Physical association	Medium	0.56	102
ZNF624	Physical association	Medium	0.56	4
ZNF696	Physical association	Medium	0.56	30
ZNF764	Physical association	Medium	0.56	26
ZNF785	Physical association	Medium	0.56	13
ZNHIT1	Physical association	Medium	0.56	22
Show allShow less

METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
KRTAP12-2 is not a metabolic protein