Protein interactions for KRTAP5-9 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	KRTAP5-9
Gene descriptionⁱ Full gene name according to HGNC.	Keratin associated protein 5-9
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Testis - Spermatid development (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enhanced (testis)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.74
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Not available
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Testis - Spermatid development

Field

Cluster

Pathway

Number of interactions:

166

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
CTSZ	Physical association	High	0.83	16
LCE1B	Physical association	High	0.83	69
RNF111	Physical association	High	0.74	13
TYRO3	Physical association	High	0.74	13
LCE3C	Physical association	High	0.74	46
ALPP	Physical association	High	0.72	30
CATSPER1	Physical association	High	0.72	95
CHIC2	Physical association	High	0.72	53
CHRD	Physical association	High	0.72	40
CNNM3	Physical association	High	0.72	59
CRCT1	Physical association	High	0.72	46
DOCK2	Physical association	High	0.72	36
FAM161A	Physical association	High	0.72	118
GLRX3	Physical association	High	0.72	78
KLHL38	Physical association	High	0.72	72
KRTAP10-11	Physical association	High	0.72	31
KRTAP10-5	Physical association	High	0.72	115
KRTAP10-8	Physical association	High	0.72	325
KRTAP10-9	Physical association	High	0.72	182
KRTAP12-1	Physical association	High	0.72	50
KRTAP12-2	Physical association	High	0.72	97
KRTAP4-11	Physical association	High	0.72	61
KRTAP4-12	Physical association	High	0.72	74
KRTAP4-2	Physical association	High	0.72	102
KRTAP5-6	Physical association	High	0.72	73
KRTAP9-2	Physical association	High	0.72	123
LCE2A	Physical association	High	0.72	43
LCE3E	Physical association	High	0.72	46
LCE4A	Physical association	High	0.72	63
MAPKBP1	Physical association	High	0.72	48
NMU	Physical association	High	0.72	14
NPDC1	Physical association	High	0.72	27
NTAQ1	Physical association	High	0.72	302
OTX1	Physical association	High	0.72	118
PRKAB2	Physical association	High	0.72	126
PSMA1	Physical association	High	0.72	135
PTPMT1	Physical association	High	0.72	25
SDCBP	Physical association	High	0.72	240
SMCP	Physical association	High	0.72	67
ZNF124	Physical association	High	0.72	45
ZNF417	Physical association	High	0.72	140
ZNF439	Physical association	High	0.72	19
ZNF587	Physical association	High	0.72	102
NTN4	Physical association	High	0.67	8
KRTAP11-1	Physical association	High	0.6	83
LCE3B	Physical association	High	0.6	34
ALDH3B1	Physical association	Medium	0.56	15
ATG9A	Physical association	Medium	0.56	11
BEX2	Physical association	Medium	0.56	67
BMP7	Physical association	Medium	0.56	13
C10orf62	Physical association	Medium	0.56	9
C11orf87	Physical association	Medium	0.56	18
CKS1B	Physical association	Medium	0.56	43
COL8A1	Physical association	Medium	0.56	51
CRH	Physical association	Medium	0.56	11
CRY2	Physical association	Medium	0.56	29
CTNNBIP1	Physical association	Medium	0.56	14
CYSRT1	Physical association	Medium	0.56	396
DCDC2	Physical association	Medium	0.56	25
DHRS1	Physical association	Medium	0.56	25
DMRT3	Physical association	Medium	0.56	65
DNASE1L3	Physical association	Medium	0.56	2
EMC7	Physical association	Medium	0.56	6
ENKD1	Physical association	Medium	0.56	159
ENPP7	Physical association	Medium	0.56	4
FAH	Physical association	Medium	0.56	6
FAM124B	Physical association	Medium	0.56	24
FAM76B	Physical association	Medium	0.56	8
FLT3LG	Physical association	Medium	0.56	1
GGN	Physical association	Medium	0.56	14
GLP1R	Physical association	Medium	0.56	10
GNE	Physical association	Medium	0.56	12
GRN	Physical association	Medium	0.56	216
GSC2	Physical association	Medium	0.56	46
HEY2	Physical association	Medium	0.56	17
HHEX	Physical association	Medium	0.56	23
HLCS	Physical association	Medium	0.56	5
HOXB9	Physical association	Medium	0.56	42
HPCAL1	Physical association	Medium	0.56	31
HSD3B7	Physical association	Medium	0.56	42
HSPD1	Physical association	Medium	0.56	35
IGFBP6	Physical association	Medium	0.56	28
JOSD1	Physical association	Medium	0.56	24
KLK8	Physical association	Medium	0.56	13
KPRP	Physical association	Medium	0.56	80
KRTAP1-3	Physical association	Medium	0.56	140
KRTAP10-10	Physical association	Medium	0.56	18
KRTAP10-6	Physical association	Medium	0.56	65
KRTAP10-7	Physical association	Medium	0.56	239
KRTAP12-3	Physical association	Medium	0.56	117
KRTAP2-4	Physical association	Medium	0.56	77
KRTAP4-4	Physical association	Medium	0.56	56
KRTAP4-5	Physical association	Medium	0.56	54
KRTAP5-11	Physical association	Medium	0.56	49
KRTAP5-2	Physical association	Medium	0.56	38
KRTAP5-3	Physical association	Medium	0.56	39
KRTAP9-3	Physical association	Medium	0.56	103
KRTAP9-4	Physical association	Medium	0.56	25
KRTAP9-8	Physical association	Medium	0.56	72
LCE1A	Physical association	Medium	0.56	59
LCE1C	Physical association	Medium	0.56	55
LCE1D	Physical association	Medium	0.56	47
LCE1E	Physical association	Medium	0.56	52
LCE1F	Physical association	Medium	0.56	61
LCE2B	Physical association	Medium	0.56	55
LCE2C	Physical association	Medium	0.56	71
LCE2D	Physical association	Medium	0.56	51
LCE3A	Physical association	Medium	0.56	54
LCE3D	Physical association	Medium	0.56	44
LCE5A	Physical association	Medium	0.56	53
LELP1	Physical association	Medium	0.56	14
LINGO1	Physical association	Medium	0.56	11
LNX1	Physical association	Medium	0.56	333
LY6H	Physical association	Medium	0.56	1
MEOX2	Physical association	Medium	0.56	158
MT1M	Physical association	Medium	0.56	6
NAXD	Physical association	Medium	0.56	13
NECTIN2	Physical association	Medium	0.56	10
NKD1	Physical association	Medium	0.56	11
NLK	Physical association	Medium	0.56	11
NOTCH2NLA	Physical association	Medium	0.56	190
NOTCH2NLC	Physical association	Medium	0.56	178
NPBWR2	Physical association	Medium	0.56	15
NR4A3	Physical association	Medium	0.56	30
NTM	Physical association	Medium	0.56	4
NUFIP2	Physical association	Medium	0.56	58
P2RX4	Physical association	Medium	0.56	6
P2RY6	Physical association	Medium	0.56	15
P4HB	Physical association	Medium	0.56	40
PCSK5	Physical association	Medium	0.56	10
PFKL	Physical association	Medium	0.56	4
PGAP6	Physical association	Medium	0.56	9
PIN1	Physical association	Medium	0.56	112
POTEB3	Physical association	Medium	0.56	7
POU4F2	Physical association	Medium	0.56	62
RAMP3	Physical association	Medium	0.56	7
RASD1	Physical association	Medium	0.56	23
RGS20	Physical association	Medium	0.56	18
SCARB1	Physical association	Medium	0.56	5
SCNM1	Physical association	Medium	0.56	148
SHFL	Physical association	Medium	0.56	26
SLC13A5	Physical association	Medium	0.56	16
SLC15A3	Physical association	Medium	0.56	5
SLC22A23	Physical association	Medium	0.56	3
SLC25A10	Physical association	Medium	0.56	6
SPINK2	Physical association	Medium	0.56	6
SPRY1	Physical association	Medium	0.56	59
SPRY2	Physical association	Medium	0.56	51
TBC1D10C	Physical association	Medium	0.56	3
TCEA2	Physical association	Medium	0.56	88
TCEANC	Physical association	Medium	0.56	24
TGM1	Physical association	Medium	0.56	24
UXT	Physical association	Medium	0.56	21
VWC2	Physical association	Medium	0.56	51
WNT11	Physical association	Medium	0.56	17
YIPF3	Physical association	Medium	0.56	13
ZBTB24	Physical association	Medium	0.56	52
ZFYVE21	Physical association	Medium	0.56	22
ZNF266	Physical association	Medium	0.56	8
ZNF408	Physical association	Medium	0.56	51
ZNF414	Physical association	Medium	0.56	42
ZNF440	Physical association	Medium	0.56	26
ZNF581	Physical association	Medium	0.56	82
ZNF655	Physical association	Medium	0.56	117
ZNF696	Physical association	Medium	0.56	30
ZNF837	Physical association	Medium	0.56	68
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
KRTAP5-9 is not a metabolic protein