Protein interactions for KRTAP10-6 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	KRTAP10-6
Gene descriptionⁱ Full gene name according to HGNC.	Keratin associated protein 10-6
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Skin - Cornification (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enriched (skin)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.99
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in single
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Not available
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Skin - Cornification

Field

Cluster

Pathway

Number of interactions:

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
ADAMTSL3	Physical association	Medium	0.56	13
AVPI1	Physical association	Medium	0.56	29
CLK4	Physical association	Medium	0.56	6
DHX57	Physical association	Medium	0.56	18
DKK2	Physical association	Medium	0.56	1
FOXD4	Physical association	Medium	0.56	4
HAND1	Physical association	Medium	0.56	2
HHEX	Physical association	Medium	0.56	23
HOXB5	Physical association	Medium	0.56	47
KIF9	Physical association	Medium	0.56	42
KRTAP10-5	Physical association	Medium	0.56	115
KRTAP4-2	Physical association	Medium	0.56	102
KRTAP4-4	Physical association	Medium	0.56	56
KRTAP4-5	Physical association	Medium	0.56	54
KRTAP5-11	Physical association	Medium	0.56	49
KRTAP5-2	Physical association	Medium	0.56	38
KRTAP5-9	Physical association	Medium	0.56	166
LCE1E	Physical association	Medium	0.56	52
LCE1F	Physical association	Medium	0.56	61
LCE2C	Physical association	Medium	0.56	71
LCE2D	Physical association	Medium	0.56	51
LCE3B	Physical association	Medium	0.56	34
LCE3E	Physical association	Medium	0.56	46
LCE4A	Physical association	Medium	0.56	63
MFSD3	Physical association	Medium	0.56	5
MT1B	Physical association	Medium	0.56	5
NAA10	Physical association	Medium	0.56	41
NAXD	Physical association	Medium	0.56	13
NKD1	Physical association	Medium	0.56	11
NMU	Physical association	Medium	0.56	14
NOL12	Physical association	Medium	0.56	10
NPDC1	Physical association	Medium	0.56	27
PBXIP1	Physical association	Medium	0.56	13
PIN1	Physical association	Medium	0.56	112
SNIP1	Physical association	Medium	0.56	21
VASN	Physical association	Medium	0.56	42
YTHDC1	Physical association	Medium	0.56	16
ZBTB24	Physical association	Medium	0.56	52
ZC3HAV1	Physical association	Medium	0.56	3
ZIM2	Physical association	Medium	0.56	26
ZNF114	Physical association	Medium	0.56	9
ZNF138	Physical association	Medium	0.56	16
ZNF155	Physical association	Medium	0.56	4
ZNF169	Physical association	Medium	0.56	5
ZNF221	Physical association	Medium	0.56	3
ZNF239	Physical association	Medium	0.56	7
ZNF264	Physical association	Medium	0.56	14
ZNF280C	Physical association	Medium	0.56	6
ZNF319	Physical association	Medium	0.56	17
ZNF418	Physical association	Medium	0.56	2
ZNF440	Physical association	Medium	0.56	26
ZNF479	Physical association	Medium	0.56	5
ZNF490	Physical association	Medium	0.56	23
ZNF543	Physical association	Medium	0.56	3
ZNF563	Physical association	Medium	0.56	1
ZNF595	Physical association	Medium	0.56	1
ZNF600	Physical association	Medium	0.56	1
ZNF669	Physical association	Medium	0.56	15
ZNF672	Physical association	Medium	0.56	3
ZNF679	Physical association	Medium	0.56	4
ZNF696	Physical association	Medium	0.56	30
ZNF774	Physical association	Medium	0.56	68
ZNF776	Physical association	Medium	0.56	1
ZNF792	Physical association	Medium	0.56	46
ZNHIT1	Physical association	Medium	0.56	22
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
KRTAP10-6 is not a metabolic protein