Protein interactions for KRT40 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	KRT40
Gene descriptionⁱ Full gene name according to HGNC.	Keratin 40
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Retina & Testis - Cilium (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Group enriched (pituitary gland, retina, skin)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.91
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Not available
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Retina & Testis - Cilium

Field

Cluster

Pathway

Number of interactions:

288

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
KRT6A	Physical association	High	0.87	30
KRT2	Physical association	High	0.81	11
ZBTB16	Physical association	High	0.81	43
KRT4	Physical association	High	0.78	17
PSMC5	Physical association	High	0.74	32
ATPAF2	Physical association	High	0.74	57
AP1M1	Physical association	High	0.72	67
ARMC7	Physical association	High	0.72	58
BYSL	Physical association	High	0.72	119
CBX8	Physical association	High	0.72	78
CCDC185	Physical association	High	0.72	34
CFAP206	Physical association	High	0.72	46
CYCS	Physical association	High	0.72	17
DMRT3	Physical association	High	0.72	65
DOCK2	Physical association	High	0.72	36
FAM90A1	Physical association	High	0.72	128
FARS2	Physical association	High	0.72	56
HGS	Physical association	High	0.72	177
JOSD1	Physical association	High	0.72	24
KRT5	Physical association	High	0.72	15
KRT6C	Physical association	High	0.72	21
KRT71	Physical association	High	0.72	18
KRT8	Physical association	High	0.72	20
KRT81	Physical association	High	0.72	22
LAGE3	Physical association	High	0.72	19
LENG1	Physical association	High	0.72	63
PIMREG	Physical association	High	0.72	18
PRKAB2	Physical association	High	0.72	126
PRPF31	Physical association	High	0.72	118
RWDD2B	Physical association	High	0.72	9
SH2D4A	Physical association	High	0.72	63
SHC3	Physical association	High	0.72	31
SMARCE1	Physical association	High	0.72	56
TEAD4	Physical association	High	0.72	30
TRAF4	Physical association	High	0.72	73
TXLNA	Physical association	High	0.72	76
USP2	Physical association	High	0.72	78
ZFP2	Physical association	High	0.72	10
ZNF202	Physical association	High	0.72	17
ZNF417	Physical association	High	0.72	140
ZNF439	Physical association	High	0.72	19
ZNF581	Physical association	High	0.72	82
ZNF587	Physical association	High	0.72	102
ZNF844	Physical association	High	0.72	11
DLGAP2	Physical association	High	0.67	2
METTL17	Physical association	High	0.67	11
MTA1	Physical association	High	0.67	23
SNAI1	Physical association	High	0.67	29
TBC1D22B	Physical association	High	0.67	46
WT1	Physical association	High	0.67	4
TNIP3	Physical association	High	0.6	26
ACSF3	Physical association	Medium	0.56	4
ADAMTS1	Physical association	Medium	0.56	3
ADAMTSL3	Physical association	Medium	0.56	13
AEN	Physical association	Medium	0.56	27
AGXT	Physical association	Medium	0.56	28
ALDH3B1	Physical association	Medium	0.56	15
AQP1	Physical association	Medium	0.56	106
AQP5	Physical association	Medium	0.56	5
ARSI	Physical association	Medium	0.56	1
ASMTL	Physical association	Medium	0.56	8
ATOSA	Physical association	Medium	0.56	5
AVPI1	Physical association	Medium	0.56	29
AXIN1	Physical association	Medium	0.56	40
BAHD1	Physical association	Medium	0.56	54
BARD1	Physical association	Medium	0.56	20
BCAS2	Physical association	Medium	0.56	49
BEX2	Physical association	Medium	0.56	67
BRME1	Physical association	Medium	0.56	19
C10orf62	Physical association	Medium	0.56	9
C11orf87	Physical association	Medium	0.56	18
C19orf73	Physical association	Medium	0.56	3
C1orf109	Physical association	Medium	0.56	121
C1orf216	Physical association	Medium	0.56	69
C2CD6	Physical association	Medium	0.56	44
C2orf68	Physical association	Medium	0.56	11
C4orf45	Physical association	Medium	0.56	16
C6orf226	Physical association	Medium	0.56	5
C8orf48	Physical association	Medium	0.56	17
CARD9	Physical association	Medium	0.56	52
CATIP	Physical association	Medium	0.56	14
CCDC112	Physical association	Medium	0.56	4
CCDC116	Physical association	Medium	0.56	24
CCDC198	Physical association	Medium	0.56	16
CCER1	Physical association	Medium	0.56	10
CCNG1	Physical association	Medium	0.56	14
CD33	Physical association	Medium	0.56	19
CDC20B	Physical association	Medium	0.56	11
CDK18	Physical association	Medium	0.56	45
CEP57	Physical association	Medium	0.56	12
CEP57L1	Physical association	Medium	0.56	27
CHCHD2	Physical association	Medium	0.56	24
CHCHD3	Physical association	Medium	0.56	37
CHIC2	Physical association	Medium	0.56	53
CLEC18A	Physical association	Medium	0.56	5
CNNM3	Physical association	Medium	0.56	59
CNTF	Physical association	Medium	0.56	14
COL8A1	Physical association	Medium	0.56	51
COX5A	Physical association	Medium	0.56	7
CRY2	Physical association	Medium	0.56	29
CTSZ	Physical association	Medium	0.56	16
CWF19L2	Physical association	Medium	0.56	65
DCDC2B	Physical association	Medium	0.56	10
DCX	Physical association	Medium	0.56	13
DDX6	Physical association	Medium	0.56	66
DHX57	Physical association	Medium	0.56	18
DOCK8	Physical association	Medium	0.56	7
DTNB	Physical association	Medium	0.56	20
EIF4E2	Physical association	Medium	0.56	32
ELOA	Physical association	Medium	0.56	38
ENKD1	Physical association	Medium	0.56	159
FAM124B	Physical association	Medium	0.56	24
FASLG	Physical association	Medium	0.56	28
FBXO34	Physical association	Medium	0.56	18
FBXW5	Physical association	Medium	0.56	21
FEZF1	Physical association	Medium	0.56	6
FKBP1B	Physical association	Medium	0.56	6
FNDC11	Physical association	Medium	0.56	37
FOXB1	Physical association	Medium	0.56	5
FRG1	Physical association	Medium	0.56	5
GADD45GIP1	Physical association	Medium	0.56	55
GARIN6	Physical association	Medium	0.56	19
GATA2	Physical association	Medium	0.56	24
GEM	Physical association	Medium	0.56	88
GFOD1	Physical association	Medium	0.56	17
GGN	Physical association	Medium	0.56	14
GNAI2	Physical association	Medium	0.56	10
GNG5	Physical association	Medium	0.56	6
GPATCH2L	Physical association	Medium	0.56	19
GTF3C5	Physical association	Medium	0.56	6
GUCD1	Physical association	Medium	0.56	6
HAPLN2	Physical association	Medium	0.56	36
HAUS1	Physical association	Medium	0.56	83
HBA1	Physical association	Medium	0.56	13
HBA2	Physical association	Medium	0.56	13
HBZ	Physical association	Medium	0.56	18
HCK	Physical association	Medium	0.56	17
HDAC4	Physical association	Medium	0.56	22
HOXB9	Physical association	Medium	0.56	42
HOXC8	Physical association	Medium	0.56	74
HSD3B7	Physical association	Medium	0.56	42
HSPA12B	Physical association	Medium	0.56	10
HSPD1	Physical association	Medium	0.56	35
ING5	Physical association	Medium	0.56	21
INO80B	Physical association	Medium	0.56	49
INPP5D	Physical association	Medium	0.56	9
IQUB	Physical association	Medium	0.56	56
ISCU	Physical association	Medium	0.56	16
KANK2	Physical association	Medium	0.56	151
KAT5	Physical association	Medium	0.56	180
KCTD9	Physical association	Medium	0.56	77
KDM1A	Physical association	Medium	0.56	86
KIFC3	Physical association	Medium	0.56	70
KLHL38	Physical association	Medium	0.56	72
KPNA2	Physical association	Medium	0.56	32
KRT20	Physical association	Medium	0.56	32
KRT6B	Physical association	Medium	0.56	20
KRT72	Physical association	Medium	0.56	16
KRT75	Physical association	Medium	0.56	103
KRT76	Physical association	Medium	0.56	33
KRT82	Physical association	Medium	0.56	11
KRT83	Physical association	Medium	0.56	31
KRT85	Physical association	Medium	0.56	22
KRT86	Physical association	Medium	0.56	38
LCE3E	Physical association	Medium	0.56	46
LIN37	Physical association	Medium	0.56	16
LMF2	Physical association	Medium	0.56	3
LMO1	Physical association	Medium	0.56	88
LMO2	Physical association	Medium	0.56	61
LMO4	Physical association	Medium	0.56	85
LRCH4	Physical association	Medium	0.56	14
MAB21L2	Physical association	Medium	0.56	11
MAGOHB	Physical association	Medium	0.56	56
MAPKBP1	Physical association	Medium	0.56	48
MFAP1	Physical association	Medium	0.56	79
MOB3C	Physical association	Medium	0.56	14
MOBP	Physical association	Medium	0.56	5
MOS	Physical association	Medium	0.56	46
MRPL11	Physical association	Medium	0.56	24
MRRF	Physical association	Medium	0.56	6
MYPOP	Physical association	Medium	0.56	33
NDEL1	Physical association	Medium	0.56	60
NEK6	Physical association	Medium	0.56	20
NFKBID	Physical association	Medium	0.56	83
NINJ1	Physical association	Medium	0.56	16
NPBWR2	Physical association	Medium	0.56	15
NPPB	Physical association	Medium	0.56	7
NXF1	Physical association	Medium	0.56	62
ODAD4	Physical association	Medium	0.56	7
OIP5	Physical association	Medium	0.56	113
PDLIM5	Physical association	Medium	0.56	9
PHF1	Physical association	Medium	0.56	45
PHF21A	Physical association	Medium	0.56	10
PIGS	Physical association	Medium	0.56	11
PIN1	Physical association	Medium	0.56	112
PKD2	Physical association	Medium	0.56	12
POP5	Physical association	Medium	0.56	14
PPP1R18	Physical association	Medium	0.56	68
PRAM1	Physical association	Medium	0.56	17
PRKAA1	Physical association	Medium	0.56	33
PRPF18	Physical association	Medium	0.56	63
PSMA1	Physical association	Medium	0.56	135
PSMB1	Physical association	Medium	0.56	83
PTPMT1	Physical association	Medium	0.56	25
RAB3IL1	Physical association	Medium	0.56	24
RAB3IP	Physical association	Medium	0.56	27
RAC1	Physical association	Medium	0.56	59
RASSF5	Physical association	Medium	0.56	21
RBM41	Physical association	Medium	0.56	23
RCOR3	Physical association	Medium	0.56	24
RPL11	Physical association	Medium	0.56	8
RSPH14	Physical association	Medium	0.56	36
RTP5	Physical association	Medium	0.56	49
SCAND1	Physical association	Medium	0.56	40
SCOC	Physical association	Medium	0.56	3
SEMA4C	Physical association	Medium	0.56	14
SHFL	Physical association	Medium	0.56	26
SLC25A10	Physical association	Medium	0.56	6
SLIRP	Physical association	Medium	0.56	11
SLU7	Physical association	Medium	0.56	22
SMCO4	Physical association	Medium	0.56	51
SNW1	Physical association	Medium	0.56	89
SPEF1	Physical association	Medium	0.56	1
SPG7	Physical association	Medium	0.56	17
SSX2	Physical association	Medium	0.56	9
SSX2B	Physical association	Medium	0.56	9
SSX2IP	Physical association	Medium	0.56	78
SUOX	Physical association	Medium	0.56	67
TACO1	Physical association	Medium	0.56	15
TBC1D21	Physical association	Medium	0.56	16
TCEA2	Physical association	Medium	0.56	88
TCHP	Physical association	Medium	0.56	40
THAP7	Physical association	Medium	0.56	47
TIE1	Physical association	Medium	0.56	7
TLE5	Physical association	Medium	0.56	105
TMEM231	Physical association	Medium	0.56	7
TNNT1	Physical association	Medium	0.56	8
TRIM42	Physical association	Medium	0.56	112
TROAP	Physical association	Medium	0.56	14
TSGA10IP	Physical association	Medium	0.56	83
TSHZ3	Physical association	Medium	0.56	24
TTC23	Physical association	Medium	0.56	17
TTC9C	Physical association	Medium	0.56	14
TTLL10	Physical association	Medium	0.56	10
TXN2	Physical association	Medium	0.56	60
TYK2	Physical association	Medium	0.56	13
TYRO3	Physical association	Medium	0.56	13
UACA	Physical association	Medium	0.56	9
UBASH3A	Physical association	Medium	0.56	7
USHBP1	Physical association	Medium	0.56	162
USP21	Physical association	Medium	0.56	5
UTP23	Physical association	Medium	0.56	22
UXT	Physical association	Medium	0.56	21
VEZF1	Physical association	Medium	0.56	40
WDR25	Physical association	Medium	0.56	5
ZBTB24	Physical association	Medium	0.56	52
ZBTB42	Physical association	Medium	0.56	38
ZC2HC1C	Physical association	Medium	0.56	18
ZFP1	Physical association	Medium	0.56	17
ZFP69B	Physical association	Medium	0.56	2
ZFYVE21	Physical association	Medium	0.56	22
ZGPAT	Physical association	Medium	0.56	25
ZMAT2	Physical association	Medium	0.56	44
ZNF101	Physical association	Medium	0.56	7
ZNF124	Physical association	Medium	0.56	45
ZNF17	Physical association	Medium	0.56	11
ZNF20	Physical association	Medium	0.56	43
ZNF230	Physical association	Medium	0.56	6
ZNF26	Physical association	Medium	0.56	4
ZNF266	Physical association	Medium	0.56	8
ZNF319	Physical association	Medium	0.56	17
ZNF329	Physical association	Medium	0.56	21
ZNF337	Physical association	Medium	0.56	8
ZNF408	Physical association	Medium	0.56	51
ZNF438	Physical association	Medium	0.56	50
ZNF488	Physical association	Medium	0.56	10
ZNF564	Physical association	Medium	0.56	30
ZNF569	Physical association	Medium	0.56	2
ZNF575	Physical association	Medium	0.56	22
ZNF580	Physical association	Medium	0.56	15
ZNF625	Physical association	Medium	0.56	4
ZNF655	Physical association	Medium	0.56	117
ZNF76	Physical association	Medium	0.56	62
ZNF792	Physical association	Medium	0.56	46
ZSCAN21	Physical association	Medium	0.56	22
ARID5A	Physical association	Medium	0.49	94
SPATA24	Physical association	Medium	0.49	6
ZNF490	Physical association	Medium	0.49	23
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
KRT40 is not a metabolic protein