Protein interactions for KANK2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	KANK2
Gene descriptionⁱ Full gene name according to HGNC.	KN motif and ankyrin repeat domains 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Smooth muscle tissue - ECM organization (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.28
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nucleoplasm In addition localized to the Cytosol
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Smooth muscle tissue - ECM organization

Field

Cluster

Pathway

Number of interactions:

151

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
EIF4E	Physical association	High	0.78	17
GOLGA2	Physical association	High	0.78	349
ABI3	Physical association	High	0.72	50
CEP70	Physical association	High	0.72	196
DYNLL1	Physical association	High	0.72	59
FHL2	Physical association	High	0.72	96
IHO1	Physical association	High	0.72	62
LMO1	Physical association	High	0.72	88
LMO4	Physical association	High	0.72	85
MAGEB4	Physical association	High	0.72	29
MOB1A	Physical association	High	0.72	20
TXLNA	Physical association	High	0.72	76
NCOA1	Physical association	Medium	0.59	14
ABT1	Physical association	Medium	0.56	13
ARL14EP	Physical association	Medium	0.56	4
ASB15	Physical association	Medium	0.56	10
BIRC7	Physical association	Medium	0.56	25
BLZF1	Physical association	Medium	0.56	84
BORCS6	Physical association	Medium	0.56	30
C11orf1	Physical association	Medium	0.56	28
C2orf68	Physical association	Medium	0.56	11
CARD10	Physical association	Medium	0.56	83
CBX8	Physical association	Medium	0.56	78
CCDC88B	Physical association	Medium	0.56	32
CDC5L	Physical association	Medium	0.56	48
CDK18	Physical association	Medium	0.56	45
CDKL3	Physical association	Medium	0.56	22
CEACAM6	Physical association	Medium	0.56	25
CEP55	Physical association	Medium	0.56	56
CHCHD3	Physical association	Medium	0.56	37
CHIC2	Physical association	Medium	0.56	53
CINP	Physical association	Medium	0.56	32
COG6	Physical association	Medium	0.56	49
CRX	Physical association	Medium	0.56	74
CUTC	Physical association	Medium	0.56	12
CWF19L2	Physical association	Medium	0.56	65
CYTH4	Physical association	Medium	0.56	14
DDIT4L	Physical association	Medium	0.56	168
DLGAP3	Physical association	Medium	0.56	6
DPEP2NB	Physical association	Medium	0.56	6
DTX2	Physical association	Medium	0.56	95
DYNLL2	Physical association	Medium	0.56	50
EFHC2	Physical association	Medium	0.56	79
ELOA	Physical association	Medium	0.56	38
EXOSC8	Physical association	Medium	0.56	46
FAM161A	Physical association	Medium	0.56	118
FAM90A1	Physical association	Medium	0.56	128
FHL3	Physical association	Medium	0.56	103
FKBP6	Physical association	Medium	0.56	26
GADD45GIP1	Physical association	Medium	0.56	55
GAS2L2	Physical association	Medium	0.56	29
GEMIN4	Physical association	Medium	0.56	28
GKAP1	Physical association	Medium	0.56	11
GMCL1	Physical association	Medium	0.56	50
GMNN	Physical association	Medium	0.56	10
GNL3L	Physical association	Medium	0.56	13
GOLGA6A	Physical association	Medium	0.56	37
GOLGA6L9	Physical association	Medium	0.56	177
GPANK1	Physical association	Medium	0.56	65
GPKOW	Physical association	Medium	0.56	40
HOMER3	Physical association	Medium	0.56	65
HSF2BP	Physical association	Medium	0.56	223
HSPB2	Physical association	Medium	0.56	19
IKZF3	Physical association	Medium	0.56	130
INO80B	Physical association	Medium	0.56	49
KIF9	Physical association	Medium	0.56	42
KIFAP3	Physical association	Medium	0.56	16
KRT27	Physical association	Medium	0.56	113
KRT34	Physical association	Medium	0.56	201
KRT40	Physical association	Medium	0.56	288
KRT75	Physical association	Medium	0.56	103
KRT86	Physical association	Medium	0.56	38
LBX1	Physical association	Medium	0.56	20
LENG1	Physical association	Medium	0.56	63
LHX1	Physical association	Medium	0.56	3
LMO2	Physical association	Medium	0.56	61
LZTS1	Physical association	Medium	0.56	73
MCCD1	Physical association	Medium	0.56	20
MCRS1	Physical association	Medium	0.56	97
MEOX1	Physical association	Medium	0.56	78
MITD1	Physical association	Medium	0.56	10
MKRN3	Physical association	Medium	0.56	118
MNS1	Physical association	Medium	0.56	23
MOB3C	Physical association	Medium	0.56	14
MORN3	Physical association	Medium	0.56	57
MSS51	Physical association	Medium	0.56	19
MYOZ3	Physical association	Medium	0.56	44
NELFE	Physical association	Medium	0.56	5
OIP5	Physical association	Medium	0.56	113
PAX6	Physical association	Medium	0.56	79
PCBD1	Physical association	Medium	0.56	12
PDLIM7	Physical association	Medium	0.56	31
PFDN6	Physical association	Medium	0.56	7
PLAGL1	Physical association	Medium	0.56	1
PLAGL2	Physical association	Medium	0.56	36
PNKP	Physical association	Medium	0.56	34
PPP1CB	Physical association	Medium	0.56	42
PRDM14	Physical association	Medium	0.56	41
PRDM6	Physical association	Medium	0.56	48
PRKAR1B	Physical association	Medium	0.56	55
PRMT5	Physical association	Medium	0.56	51
PRPF18	Physical association	Medium	0.56	63
PRPF31	Physical association	Medium	0.56	118
PRR5L	Physical association	Medium	0.56	13
PSMB4	Physical association	Medium	0.56	31
PSTPIP1	Physical association	Medium	0.56	42
RAB11FIP2	Physical association	Medium	0.56	10
RALBP1	Physical association	Medium	0.56	36
RBCK1	Physical association	Medium	0.56	21
RHOH	Physical association	Medium	0.56	11
RNF8	Physical association	Medium	0.56	41
SCNM1	Physical association	Medium	0.56	148
SERTAD3	Physical association	Medium	0.56	37
SNAPIN	Physical association	Medium	0.56	36
SNW1	Physical association	Medium	0.56	89
SORBS3	Physical association	Medium	0.56	87
STAC	Physical association	Medium	0.56	15
TAX1BP1	Physical association	Medium	0.56	58
TFIP11	Physical association	Medium	0.56	179
TGM5	Physical association	Medium	0.56	6
THAP1	Physical association	Medium	0.56	81
THAP6	Physical association	Medium	0.56	13
TIFA	Physical association	Medium	0.56	20
TLE5	Physical association	Medium	0.56	105
TOP3B	Physical association	Medium	0.56	10
TRAF1	Physical association	Medium	0.56	166
TRAF2	Physical association	Medium	0.56	237
TRAF4	Physical association	Medium	0.56	73
TRIB3	Physical association	Medium	0.56	54
TRIM54	Physical association	Medium	0.56	151
TSGA10	Physical association	Medium	0.56	54
TSGA10IP	Physical association	Medium	0.56	83
TSPYL6	Physical association	Medium	0.56	9
UBAP2	Physical association	Medium	0.56	25
USHBP1	Physical association	Medium	0.56	162
UTP14C	Physical association	Medium	0.56	17
VMAC	Physical association	Medium	0.56	12
VPS52	Physical association	Medium	0.56	83
VWC2	Physical association	Medium	0.56	51
ZBTB42	Physical association	Medium	0.56	38
ZMAT2	Physical association	Medium	0.56	44
ZMYND12	Physical association	Medium	0.56	66
ZNF212	Physical association	Medium	0.56	13
ZNF414	Physical association	Medium	0.56	42
ZNF417	Physical association	Medium	0.56	140
ZNF512	Physical association	Medium	0.56	1
ZNF648	Physical association	Medium	0.56	50
ZNF774	Physical association	Medium	0.56	68
ZNF784	Physical association	Medium	0.56	6
ZNHIT1	Physical association	Medium	0.56	22
ZRANB1	Physical association	Medium	0.56	112
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
KANK2 is not a metabolic protein