Protein interactions for TSGA10 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TSGA10
Gene descriptionⁱ Full gene name according to HGNC.	Testis specific 10
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Ciliated cells - Cilium organization (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enriched (testis)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.79
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Cytosol
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Ciliated cells - Cilium organization

Field

Cluster

Pathway

Number of interactions:

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
CDC73	Physical association	High	0.72	30
CEP44	Physical association	High	0.72	40
PRPF31	Physical association	High	0.72	118
BIRC2	Physical association	High	0.67	30
AARD	Physical association	Medium	0.56	13
AXIN2	Physical association	Medium	0.56	36
CBX8	Physical association	Medium	0.56	78
CBY2	Physical association	Medium	0.56	51
CCDC88B	Physical association	Medium	0.56	32
CDK18	Physical association	Medium	0.56	45
COG6	Physical association	Medium	0.56	49
FAM161B	Physical association	Medium	0.56	54
GOLGA2	Physical association	Medium	0.56	349
HDX	Physical association	Medium	0.56	10
HNRNPM	Physical association	Medium	0.56	15
KANK2	Physical association	Medium	0.56	151
KIAA1328	Physical association	Medium	0.56	28
KRT76	Physical association	Medium	0.56	33
LZTS1	Physical association	Medium	0.56	73
MAD1L1	Physical association	Medium	0.56	38
MATR3	Physical association	Medium	0.56	14
MBD3L1	Physical association	Medium	0.56	28
NAB2	Physical association	Medium	0.56	62
PAK5	Physical association	Medium	0.56	30
PKN1	Physical association	Medium	0.56	59
PPHLN1	Physical association	Medium	0.56	4
PPP1R13B	Physical association	Medium	0.56	54
PPP1R18	Physical association	Medium	0.56	68
PRDM14	Physical association	Medium	0.56	41
PRDM6	Physical association	Medium	0.56	48
RBAK	Physical association	Medium	0.56	20
RCOR3	Physical association	Medium	0.56	24
RTP5	Physical association	Medium	0.56	49
SCEL	Physical association	Medium	0.56	6
SORBS3	Physical association	Medium	0.56	87
TCEA2	Physical association	Medium	0.56	88
TLE5	Physical association	Medium	0.56	105
TRIM14	Physical association	Medium	0.56	26
ZBTB24	Physical association	Medium	0.56	52
ZBTB26	Physical association	Medium	0.56	27
ZBTB39	Physical association	Medium	0.56	9
ZNF124	Physical association	Medium	0.56	45
ZNF205	Physical association	Medium	0.56	6
ZNF23	Physical association	Medium	0.56	14
ZNF410	Physical association	Medium	0.56	10
ZNF417	Physical association	Medium	0.56	140
ZNF426	Physical association	Medium	0.56	33
ZNF438	Physical association	Medium	0.56	50
ZNF490	Physical association	Medium	0.56	23
ZNF544	Physical association	Medium	0.56	4
ZNF587	Physical association	Medium	0.56	102
ZNF599	Physical association	Medium	0.56	7
ZNF670	Physical association	Medium	0.56	19
FAM161A	Physical association	Medium	0.49	118
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
TSGA10 is not a metabolic protein