Protein interactions for DDIT4L - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DDIT4L
Gene descriptionⁱ Full gene name according to HGNC.	DNA damage inducible transcript 4 like
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Skeletal muscle - Striated muscle contraction (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Group enriched (skeletal muscle, tongue)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.76
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Plasma membrane In addition localized to the Nucleoplasm, Actin filaments
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Skeletal muscle - Striated muscle contraction

Field

Cluster

Pathway

Number of interactions:

168

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
SNRPG	Physical association	High	0.86	11
LSM7	Physical association	High	0.78	11
MORF4L2	Physical association	High	0.72	42
NAA10	Physical association	High	0.6	41
TSSK3	Physical association	High	0.6	51
ABCB11	Physical association	Medium	0.56	1
ACY3	Physical association	Medium	0.56	15
AFMID	Physical association	Medium	0.56	3
AIDA	Physical association	Medium	0.56	6
AKT1	Physical association	Medium	0.56	58
ARHGEF3	Physical association	Medium	0.56	7
ARPIN	Physical association	Medium	0.56	3
BAG4	Physical association	Medium	0.56	60
BCL2L14	Physical association	Medium	0.56	5
BID	Physical association	Medium	0.56	12
C14orf119	Physical association	Medium	0.56	46
C18orf25	Physical association	Medium	0.56	6
C19orf25	Physical association	Medium	0.56	18
C5orf22	Physical association	Medium	0.56	3
CABP5	Physical association	Medium	0.56	30
CALCOCO2	Physical association	Medium	0.56	117
CATIP	Physical association	Medium	0.56	14
CCNH	Physical association	Medium	0.56	37
CDA	Physical association	Medium	0.56	14
CDC45	Physical association	Medium	0.56	10
CDKN2D	Physical association	Medium	0.56	41
CDPF1	Physical association	Medium	0.56	11
CEP19	Physical association	Medium	0.56	41
CHMP1A	Physical association	Medium	0.56	14
CLIC3	Physical association	Medium	0.56	22
CLK2	Physical association	Medium	0.56	45
CLK3	Physical association	Medium	0.56	34
CPSF1	Physical association	Medium	0.56	9
CRLF3	Physical association	Medium	0.56	24
CRYBB1	Physical association	Medium	0.56	6
CSK	Physical association	Medium	0.56	10
CTAG1A	Physical association	Medium	0.56	57
CTAG1B	Physical association	Medium	0.56	57
DCTPP1	Physical association	Medium	0.56	6
DEUP1	Physical association	Medium	0.56	34
DNPH1	Physical association	Medium	0.56	5
DOK4	Physical association	Medium	0.56	8
DUSP23	Physical association	Medium	0.56	7
DUSP29	Physical association	Medium	0.56	15
EIF4A3	Physical association	Medium	0.56	30
EIF4EBP1	Physical association	Medium	0.56	11
EML3	Physical association	Medium	0.56	5
ENSG00000290147	Physical association	Medium	0.56	7
EXOSC1	Physical association	Medium	0.56	19
EXOSC5	Physical association	Medium	0.56	42
EXOSC8	Physical association	Medium	0.56	46
FADD	Physical association	Medium	0.56	17
FHIT	Physical association	Medium	0.56	3
FHL2	Physical association	Medium	0.56	96
FKBP6	Physical association	Medium	0.56	26
GADD45G	Physical association	Medium	0.56	27
GEMIN6	Physical association	Medium	0.56	8
GET3	Physical association	Medium	0.56	32
GPKOW	Physical association	Medium	0.56	40
GRB2	Physical association	Medium	0.56	165
GTF2H5	Physical association	Medium	0.56	11
GTPBP3	Physical association	Medium	0.56	18
GUCA1A	Physical association	Medium	0.56	7
HMG20A	Physical association	Medium	0.56	52
HSPB7	Physical association	Medium	0.56	15
IL36RN	Physical association	Medium	0.56	11
KANK2	Physical association	Medium	0.56	151
KCTD9	Physical association	Medium	0.56	77
KRT34	Physical association	Medium	0.56	201
KRTAP5-6	Physical association	Medium	0.56	73
LENG1	Physical association	Medium	0.56	63
LGALS14	Physical association	Medium	0.56	43
LGALS7	Physical association	Medium	0.56	6
LGALS7B	Physical association	Medium	0.56	6
LGALSL	Physical association	Medium	0.56	4
LMO1	Physical association	Medium	0.56	88
LRATD2	Physical association	Medium	0.56	6
LSM3	Physical association	Medium	0.56	19
LSM5	Physical association	Medium	0.56	12
MAGEB2	Physical association	Medium	0.56	7
MAPRE2	Physical association	Medium	0.56	13
MAPRE3	Physical association	Medium	0.56	41
MEMO1	Physical association	Medium	0.56	16
MIEN1	Physical association	Medium	0.56	9
MKRN3	Physical association	Medium	0.56	118
MT1M	Physical association	Medium	0.56	6
MYDGF	Physical association	Medium	0.56	12
MYG1	Physical association	Medium	0.56	35
MYL6	Physical association	Medium	0.56	8
MYLIP	Physical association	Medium	0.56	29
NDEL1	Physical association	Medium	0.56	60
NEK7	Physical association	Medium	0.56	65
NGB	Physical association	Medium	0.56	13
NHLRC4	Physical association	Medium	0.56	15
NIBAN1	Physical association	Medium	0.56	4
NME7	Physical association	Medium	0.56	62
NQO2	Physical association	Medium	0.56	5
NR2C2AP	Physical association	Medium	0.56	8
NUDT11	Physical association	Medium	0.56	1
NUDT2	Physical association	Medium	0.56	3
NUDT22	Physical association	Medium	0.56	17
NUDT3	Physical association	Medium	0.56	3
P4HB	Physical association	Medium	0.56	40
PADI6	Physical association	Medium	0.56	4
PARVG	Physical association	Medium	0.56	23
PBK	Physical association	Medium	0.56	5
PFKFB1	Physical association	Medium	0.56	11
PLAA	Physical association	Medium	0.56	5
PLSCR4	Physical association	Medium	0.56	45
PM20D2	Physical association	Medium	0.56	18
PMVK	Physical association	Medium	0.56	1
POU1F1	Physical association	Medium	0.56	9
PPCDC	Physical association	Medium	0.56	10
PPIL1	Physical association	Medium	0.56	14
PPP1R27	Physical association	Medium	0.56	10
PRKAB2	Physical association	Medium	0.56	126
PRPF18	Physical association	Medium	0.56	63
PRPS1	Physical association	Medium	0.56	79
PSMA1	Physical association	Medium	0.56	135
PSMB9	Physical association	Medium	0.56	7
PTS	Physical association	Medium	0.56	8
RAB32	Physical association	Medium	0.56	3
RFC5	Physical association	Medium	0.56	21
RFPL3	Physical association	Medium	0.56	8
RNF8	Physical association	Medium	0.56	41
RPIA	Physical association	Medium	0.56	15
RPL22	Physical association	Medium	0.56	16
RPRD1B	Physical association	Medium	0.56	14
SEC22A	Physical association	Medium	0.56	88
SEPTIN1	Physical association	Medium	0.56	17
SEPTIN3	Physical association	Medium	0.56	14
SEPTIN5	Physical association	Medium	0.56	14
SH2D1A	Physical association	Medium	0.56	15
SH2D1B	Physical association	Medium	0.56	14
SH3BGRL3	Physical association	Medium	0.56	2
SNRPA	Physical association	Medium	0.56	36
SORL1	Physical association	Medium	0.56	18
SREK1IP1	Physical association	Medium	0.56	25
STAC3	Physical association	Medium	0.56	30
STK16	Physical association	Medium	0.56	66
SULT2B1	Physical association	Medium	0.56	9
SUOX	Physical association	Medium	0.56	67
TARS2	Physical association	Medium	0.56	11
TBC1D22B	Physical association	Medium	0.56	46
TCF19	Physical association	Medium	0.56	12
TCL1A	Physical association	Medium	0.56	34
TCP11L1	Physical association	Medium	0.56	18
TEKT4	Physical association	Medium	0.56	80
TEX14	Physical association	Medium	0.56	3
TOLLIP	Physical association	Medium	0.56	41
TSEN15	Physical association	Medium	0.56	21
TTC5	Physical association	Medium	0.56	7
TXN	Physical association	Medium	0.56	26
TXNL4A	Physical association	Medium	0.56	6
TYW3	Physical association	Medium	0.56	2
UBE2B	Physical association	Medium	0.56	6
UBTFL1	Physical association	Medium	0.56	22
VBP1	Physical association	Medium	0.56	26
VEZF1	Physical association	Medium	0.56	40
WHRN	Physical association	Medium	0.56	8
YES1	Physical association	Medium	0.56	44
YOD1	Physical association	Medium	0.56	17
YPEL5	Physical association	Medium	0.56	24
ZBED8	Physical association	Medium	0.56	3
ZIC1	Physical association	Medium	0.56	55
ZNF593	Physical association	Medium	0.56	3
ZNF76	Physical association	Medium	0.56	62
ZSCAN23	Physical association	Medium	0.56	17
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
DDIT4L is not a metabolic protein