Protein interactions for HMG20A - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HMG20A
Gene descriptionⁱ Full gene name according to HGNC.	High mobility group 20A
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Transcription (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.21
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nucleoplasm
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Transcription

Field

Cluster

Pathway

Number of interactions:

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
RPP30	Physical association	High	0.78	3
SCNM1	Physical association	High	0.78	148
SYTL4	Physical association	High	0.78	19
HMG20B	Physical association	High	0.67	16
DTNB	Physical association	High	0.67	20
HPCAL1	Physical association	High	0.67	31
MAGOHB	Physical association	High	0.67	56
KDM1A	Physical association	High	0.64	86
RCOR1	Physical association	High	0.64	5
AGR2	Physical association	Medium	0.56	62
BACH2	Physical association	Medium	0.56	40
BYSL	Physical association	Medium	0.56	119
C9orf72	Physical association	Medium	0.56	11
CCDC6	Physical association	Medium	0.56	21
CEP95	Physical association	Medium	0.56	13
CFAP53	Physical association	Medium	0.56	23
CTAG1A	Physical association	Medium	0.56	57
CTAG1B	Physical association	Medium	0.56	57
DDIT4L	Physical association	Medium	0.56	168
DGCR6L	Physical association	Medium	0.56	13
EHHADH	Physical association	Medium	0.56	94
FOXD4L1	Physical association	Medium	0.56	17
GADD45GIP1	Physical association	Medium	0.56	55
KPNA2	Physical association	Medium	0.56	32
KRT1	Physical association	Medium	0.56	32
LMO1	Physical association	Medium	0.56	88
LNX1	Physical association	Medium	0.56	333
LURAP1	Physical association	Medium	0.56	17
NTAQ1	Physical association	Medium	0.56	302
NUTF2	Physical association	Medium	0.56	31
OLIG3	Physical association	Medium	0.56	24
PICK1	Physical association	Medium	0.56	275
PSMB1	Physical association	Medium	0.56	83
PSORS1C2	Physical association	Medium	0.56	18
PTH2R	Physical association	Medium	0.56	2
QARS1	Physical association	Medium	0.56	53
RAD54L2	Physical association	Medium	0.56	19
RIN1	Physical association	Medium	0.56	38
RPRD1B	Physical association	Medium	0.56	14
RSPH9	Physical association	Medium	0.56	3
RUSC1	Physical association	Medium	0.56	71
SLC30A8	Physical association	Medium	0.56	66
SMYD1	Physical association	Medium	0.56	24
SUOX	Physical association	Medium	0.56	67
TBC1D22B	Physical association	Medium	0.56	46
TCHP	Physical association	Medium	0.56	40
TCP11L1	Physical association	Medium	0.56	18
TRAF4	Physical association	Medium	0.56	73
TRAPPC5	Physical association	Medium	0.56	3
USHBP1	Physical association	Medium	0.56	162
HTT	Physical association	Medium	0.51	665
TESC	Physical association	Medium	0.51	3
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
HMG20A is not a metabolic protein