Protein interactions for BAG4 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	BAG4
Gene descriptionⁱ Full gene name according to HGNC.	BAG cochaperone 4
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Unknown function (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.38
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Not available
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Unknown function

Field

Cluster

Pathway

Number of interactions:

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
DCP1A	Physical association	High	0.73	16
HSPA2	Physical association	High	0.7	38
TBC1D7	Physical association	High	0.7	22
HSPA1L	Physical association	High	0.67	9
HSPA8	Physical association	High	0.67	35
FTH1	Physical association	High	0.6	8
RAMAC	Physical association	High	0.6	37
DCP1B	Physical association	Medium	0.56	6
ARID5A	Physical association	Medium	0.56	94
ATOSB	Physical association	Medium	0.56	50
ATP23	Physical association	Medium	0.56	22
BLZF1	Physical association	Medium	0.56	84
CASP2	Physical association	Medium	0.56	3
DDIT4L	Physical association	Medium	0.56	168
DZIP3	Physical association	Medium	0.56	24
EFEMP1	Physical association	Medium	0.56	27
FAM222B	Physical association	Medium	0.56	25
FARS2	Physical association	Medium	0.56	56
GPANK1	Physical association	Medium	0.56	65
GPS2	Physical association	Medium	0.56	31
HSPA6	Physical association	Medium	0.56	11
KCTD6	Physical association	Medium	0.56	20
KIF5B	Physical association	Medium	0.56	17
KRTAP13-4	Physical association	Medium	0.56	6
KRTAP4-12	Physical association	Medium	0.56	74
KRTAP4-2	Physical association	Medium	0.56	102
KRTAP4-4	Physical association	Medium	0.56	56
KRTAP4-5	Physical association	Medium	0.56	54
MAGED1	Physical association	Medium	0.56	79
MEI4	Physical association	Medium	0.56	32
MYOZ1	Physical association	Medium	0.56	28
MYOZ3	Physical association	Medium	0.56	44
MYPOP	Physical association	Medium	0.56	33
ODF1	Physical association	Medium	0.56	7
ODF3L1	Physical association	Medium	0.56	2
P4HA3	Physical association	Medium	0.56	39
PDCD6	Physical association	Medium	0.56	12
PEF1	Physical association	Medium	0.56	26
PGRMC2	Physical association	Medium	0.56	53
PHF19	Physical association	Medium	0.56	24
PPIL6	Physical association	Medium	0.56	4
PSMB5	Physical association	Medium	0.56	17
PYCR3	Physical association	Medium	0.56	5
SAXO1	Physical association	Medium	0.56	39
SH3RF2	Physical association	Medium	0.56	9
SNRPC	Physical association	Medium	0.56	43
SUOX	Physical association	Medium	0.56	67
TBC1D3G	Physical association	Medium	0.56	8
TCL1B	Physical association	Medium	0.56	11
TEKT5	Physical association	Medium	0.56	28
TFAP2D	Physical association	Medium	0.56	48
TINAGL1	Physical association	Medium	0.56	4
TSG101	Physical association	Medium	0.56	50
VPS37C	Physical association	Medium	0.56	72
ZBTB45	Physical association	Medium	0.56	1
ZBTB5	Physical association	Medium	0.56	5
ZIM2	Physical association	Medium	0.56	26
DNAJC7	Physical association	Medium	0.5	3
GRAP2	Physical association	Medium	0.49	41
RPL22	Physical association	Medium	0.49	16
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
BAG4 is not a metabolic protein