Protein interactions for SPG21 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SPG21
Gene descriptionⁱ Full gene name according to HGNC.	SPG21 abhydrolase domain containing, maspardin
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Glycosylation (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.18
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Vesicles, Cytosol
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Glycosylation

Field

Cluster

Pathway

Number of interactions:

129

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
ATPAF2	Physical association	High	0.86	57
PRPS1	Physical association	High	0.83	79
TRAF2	Physical association	High	0.83	237
AKIRIN2	Physical association	High	0.8	7
CRYAA	Physical association	High	0.78	72
CUTC	Physical association	High	0.78	12
DTX2	Physical association	High	0.78	95
FAM114A1	Physical association	High	0.78	7
RABAC1	Physical association	High	0.78	48
S100B	Physical association	High	0.78	32
SPRED2	Physical association	High	0.78	38
AGTRAP	Physical association	High	0.74	59
ARL6IP1	Physical association	High	0.72	60
CCDC102B	Physical association	High	0.72	87
DTX3L	Physical association	High	0.72	2
EFHC2	Physical association	High	0.72	79
IKZF3	Physical association	High	0.72	130
INCA1	Physical association	High	0.72	204
TFG	Physical association	High	0.72	45
TRAF1	Physical association	High	0.72	166
TRIM54	Physical association	High	0.72	151
TRIM9	Physical association	High	0.72	18
CTPS2	Physical association	High	0.67	2
GGA2	Physical association	High	0.67	12
REEP6	Physical association	High	0.67	11
TCF12	Physical association	High	0.67	28
ACOT13	Physical association	Medium	0.56	5
APOC1	Physical association	Medium	0.56	23
ARL8A	Physical association	Medium	0.56	6
ARMC7	Physical association	Medium	0.56	58
ATP5ME	Physical association	Medium	0.56	3
BORCS6	Physical association	Medium	0.56	30
BSND	Physical association	Medium	0.56	25
C9orf24	Physical association	Medium	0.56	22
CDK2AP1	Physical association	Medium	0.56	6
CDKN2B	Physical association	Medium	0.56	15
CEP76	Physical association	Medium	0.56	79
CEPT1	Physical association	Medium	0.56	2
CIDEB	Physical association	Medium	0.56	58
CLDN22	Physical association	Medium	0.56	5
CMTM5	Physical association	Medium	0.56	38
CMTM6	Physical association	Medium	0.56	17
COG6	Physical association	Medium	0.56	49
CRX	Physical association	Medium	0.56	74
CT55	Physical association	Medium	0.56	22
DCTPP1	Physical association	Medium	0.56	6
EIF1B	Physical association	Medium	0.56	4
GAD2	Physical association	Medium	0.56	36
GAS8	Physical association	Medium	0.56	97
GEMIN2	Physical association	Medium	0.56	15
GEMIN4	Physical association	Medium	0.56	28
GOLGA2	Physical association	Medium	0.56	349
GOLT1B	Physical association	Medium	0.56	8
GRPEL1	Physical association	Medium	0.56	4
HNRNPH1	Physical association	Medium	0.56	30
HPRT1	Physical association	Medium	0.56	10
HSD17B13	Physical association	Medium	0.56	104
KCTD9	Physical association	Medium	0.56	77
KRT13	Physical association	Medium	0.56	20
KRT15	Physical association	Medium	0.56	100
KRT19	Physical association	Medium	0.56	65
KRT31	Physical association	Medium	0.56	284
LEPROTL1	Physical association	Medium	0.56	68
LMO1	Physical association	Medium	0.56	88
LNX1	Physical association	Medium	0.56	333
LSMEM2	Physical association	Medium	0.56	18
MAB21L3	Physical association	Medium	0.56	24
MPC2	Physical association	Medium	0.56	14
MYG1	Physical association	Medium	0.56	35
MYOG	Physical association	Medium	0.56	27
N4BP3	Physical association	Medium	0.56	12
NAB2	Physical association	Medium	0.56	62
NDUFAF2	Physical association	Medium	0.56	7
NIF3L1	Physical association	Medium	0.56	52
NME4	Physical association	Medium	0.56	43
NQO2	Physical association	Medium	0.56	5
NR1D1	Physical association	Medium	0.56	5
NRDE2	Physical association	Medium	0.56	7
NUP54	Physical association	Medium	0.56	40
PAX6	Physical association	Medium	0.56	79
PBX4	Physical association	Medium	0.56	60
PCBD2	Physical association	Medium	0.56	8
PCNA	Physical association	Medium	0.56	35
PDE5A	Physical association	Medium	0.56	3
PEF1	Physical association	Medium	0.56	26
PFDN5	Physical association	Medium	0.56	81
PLP2	Physical association	Medium	0.56	58
PNMA5	Physical association	Medium	0.56	53
PPM1J	Physical association	Medium	0.56	3
PRTFDC1	Physical association	Medium	0.56	13
PSMB4	Physical association	Medium	0.56	31
ROPN1	Physical association	Medium	0.56	37
RPRD1B	Physical association	Medium	0.56	14
RPS19	Physical association	Medium	0.56	6
RTL8B	Physical association	Medium	0.56	7
SATB1	Physical association	Medium	0.56	4
SCAMP1	Physical association	Medium	0.56	13
SEPTIN5	Physical association	Medium	0.56	14
SFT2D1	Physical association	Medium	0.56	27
SH3GL1	Physical association	Medium	0.56	21
SLC35E3	Physical association	Medium	0.56	22
SORBS3	Physical association	Medium	0.56	87
SPRED1	Physical association	Medium	0.56	308
SSBP4	Physical association	Medium	0.56	5
SWSAP1	Physical association	Medium	0.56	9
SYNGR3	Physical association	Medium	0.56	15
SYP	Physical association	Medium	0.56	29
TCF4	Physical association	Medium	0.56	124
TEKT4	Physical association	Medium	0.56	80
TFIP11	Physical association	Medium	0.56	179
TMEM208	Physical association	Medium	0.56	18
TRIB3	Physical association	Medium	0.56	54
TRIM14	Physical association	Medium	0.56	26
TRIM23	Physical association	Medium	0.56	142
TRIM50	Physical association	Medium	0.56	31
TSGA10IP	Physical association	Medium	0.56	83
TSNAXIP1	Physical association	Medium	0.56	4
TTC23L	Physical association	Medium	0.56	19
TXN	Physical association	Medium	0.56	26
TXNL4B	Physical association	Medium	0.56	11
UFSP1	Physical association	Medium	0.56	30
USHBP1	Physical association	Medium	0.56	162
VMAC	Physical association	Medium	0.56	12
VPS25	Physical association	Medium	0.56	15
ZBTB42	Physical association	Medium	0.56	38
ZMYND12	Physical association	Medium	0.56	66
ZNF581	Physical association	Medium	0.56	82
ZNF629	Physical association	Medium	0.56	14
RTN4	Physical association	Medium	0.55	9
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
SPG21 is not a metabolic protein