Protein interactions for HSD17B13 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HSD17B13
Gene descriptionⁱ Full gene name according to HGNC.	Hydroxysteroid 17-beta dehydrogenase 13
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Liver - Plasma proteins (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enriched (liver)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.88
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Vesicles In addition localized to the Golgi apparatus
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Liver - Plasma proteins

Field

Cluster

Pathway

Number of interactions:

104

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
ABHD16A	Physical association	Medium	0.56	46
ADGRE2	Physical association	Medium	0.56	18
AGPAT3	Physical association	Medium	0.56	16
AGPAT4	Physical association	Medium	0.56	22
AOC3	Physical association	Medium	0.56	10
APOA2	Physical association	Medium	0.56	15
ARL6IP1	Physical association	Medium	0.56	60
ATP6V0C	Physical association	Medium	0.56	47
BBC3	Physical association	Medium	0.56	12
C3orf52	Physical association	Medium	0.56	57
CACNG1	Physical association	Medium	0.56	15
CALHM6	Physical association	Medium	0.56	2
CCDC167	Physical association	Medium	0.56	32
CDIPT	Physical association	Medium	0.56	47
CLDN10	Physical association	Medium	0.56	7
CLDN4	Physical association	Medium	0.56	14
CLDND2	Physical association	Medium	0.56	24
CMTM7	Physical association	Medium	0.56	39
CYB5R3	Physical association	Medium	0.56	50
CYBC1	Physical association	Medium	0.56	51
CYP4F2	Physical association	Medium	0.56	33
DIABLO	Physical association	Medium	0.56	25
EBP	Physical association	Medium	0.56	159
ECPAS	Physical association	Medium	0.56	8
FATE1	Physical association	Medium	0.56	78
FAXDC2	Physical association	Medium	0.56	28
FETUB	Physical association	Medium	0.56	6
GJB2	Physical association	Medium	0.56	33
GOLM1	Physical association	Medium	0.56	45
GOSR2	Physical association	Medium	0.56	45
GYPB	Physical association	Medium	0.56	4
HSD3B7	Physical association	Medium	0.56	42
IGFBP5	Physical association	Medium	0.56	63
INSIG2	Physical association	Medium	0.56	34
ITGAM	Physical association	Medium	0.56	34
JAGN1	Physical association	Medium	0.56	102
LPCAT2	Physical association	Medium	0.56	7
LRAT	Physical association	Medium	0.56	3
MARCHF5	Physical association	Medium	0.56	25
MFSD5	Physical association	Medium	0.56	46
MMP14	Physical association	Medium	0.56	17
MOSPD3	Physical association	Medium	0.56	13
MS4A1	Physical association	Medium	0.56	27
NAPB	Physical association	Medium	0.56	28
NAT8	Physical association	Medium	0.56	25
NRM	Physical association	Medium	0.56	50
ORMDL3	Physical association	Medium	0.56	23
PLIN3	Physical association	Medium	0.56	22
PLN	Physical association	Medium	0.56	44
PLP2	Physical association	Medium	0.56	58
PNLIPRP1	Physical association	Medium	0.56	31
PTPN9	Physical association	Medium	0.56	39
RABAC1	Physical association	Medium	0.56	48
RPRM	Physical association	Medium	0.56	66
RUSF1	Physical association	Medium	0.56	49
SACM1L	Physical association	Medium	0.56	26
SCAMP5	Physical association	Medium	0.56	15
SCARF1	Physical association	Medium	0.56	18
SCD	Physical association	Medium	0.56	36
SEC22B	Physical association	Medium	0.56	45
SERP1	Physical association	Medium	0.56	37
SFT2D2	Physical association	Medium	0.56	24
SFXN1	Physical association	Medium	0.56	14
SFXN2	Physical association	Medium	0.56	5
SFXN3	Physical association	Medium	0.56	16
SLC25A46	Physical association	Medium	0.56	15
SLC30A3	Physical association	Medium	0.56	22
SLC35B4	Physical association	Medium	0.56	25
SLC35E4	Physical association	Medium	0.56	12
SMIM1	Physical association	Medium	0.56	48
SNORC	Physical association	Medium	0.56	20
SPG21	Physical association	Medium	0.56	129
STRIT1	Physical association	Medium	0.56	32
STX5	Physical association	Medium	0.56	26
STX7	Physical association	Medium	0.56	36
TBRG4	Physical association	Medium	0.56	17
TF	Physical association	Medium	0.56	20
THSD7A	Physical association	Medium	0.56	12
TIMM23	Physical association	Medium	0.56	18
TIMMDC1	Physical association	Medium	0.56	53
TMEM100	Physical association	Medium	0.56	32
TMEM120A	Physical association	Medium	0.56	21
TMEM140	Physical association	Medium	0.56	44
TMEM14C	Physical association	Medium	0.56	35
TMEM167B	Physical association	Medium	0.56	28
TMEM19	Physical association	Medium	0.56	34
TMEM203	Physical association	Medium	0.56	34
TMEM222	Physical association	Medium	0.56	30
TMEM229B	Physical association	Medium	0.56	34
TMEM243	Physical association	Medium	0.56	37
TMEM255B	Physical association	Medium	0.56	5
TMEM42	Physical association	Medium	0.56	41
TMEM60	Physical association	Medium	0.56	86
TMEM86B	Physical association	Medium	0.56	92
TMEM97	Physical association	Medium	0.56	49
TMX2	Physical association	Medium	0.56	131
TPRG1	Physical association	Medium	0.56	15
UBXN8	Physical association	Medium	0.56	7
UNC50	Physical association	Medium	0.56	29
VAMP2	Physical association	Medium	0.56	25
VAPA	Physical association	Medium	0.56	37
VAPB	Physical association	Medium	0.56	33
YIPF2	Physical association	Medium	0.56	19
YIPF4	Physical association	Medium	0.56	28
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
HSD17B13 is not a metabolic protein