Protein interactions for KASH5 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	KASH5
Gene descriptionⁱ Full gene name according to HGNC.	KASH domain containing 5
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Testis - Transcription (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enriched (testis)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.95
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Not available
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Testis - Transcription

Field

Cluster

Pathway

Number of interactions:

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
LHFPL5	Physical association	High	0.81	108
SLC30A2	Physical association	High	0.81	55
BCL2L2	Physical association	High	0.79	45
BCL2L2-PABPN1	Physical association	High	0.79	45
EMD	Physical association	High	0.79	72
RIPPLY2	Physical association	High	0.79	9
SGTA	Physical association	High	0.79	136
BAG5	Physical association	High	0.72	13
CDC73	Physical association	High	0.72	30
CRABP2	Physical association	High	0.72	3
CYBC1	Physical association	High	0.72	51
FATE1	Physical association	High	0.72	78
GALNT2	Physical association	High	0.72	5
GOSR2	Physical association	High	0.72	45
GPR25	Physical association	High	0.72	27
JAGN1	Physical association	High	0.72	102
MTX2	Physical association	High	0.72	4
NRIP3	Physical association	High	0.72	6
NSG1	Physical association	High	0.72	25
PPP1R18	Physical association	High	0.72	68
SENP2	Physical association	High	0.72	18
SERP2	Physical association	High	0.72	42
SLC41A2	Physical association	High	0.72	28
STX5	Physical association	High	0.72	26
TRAF3IP3	Physical association	High	0.72	45
TMEM11	Physical association	High	0.7	40
SUN1	Direct interaction	High	0.62	4
ABHD1	Physical association	Medium	0.56	1
ADIPOQ	Physical association	Medium	0.56	46
ATF7	Physical association	Medium	0.56	8
BET1	Physical association	Medium	0.56	41
C14orf180	Physical association	Medium	0.56	38
CCDC120	Physical association	Medium	0.56	90
CDKL3	Physical association	Medium	0.56	22
CIB3	Physical association	Medium	0.56	44
CLDN8	Physical association	Medium	0.56	8
CTXN3	Physical association	Medium	0.56	51
CWF19L2	Physical association	Medium	0.56	65
CXCL9	Physical association	Medium	0.56	44
DERL1	Physical association	Medium	0.56	25
DNAJC30	Physical association	Medium	0.56	23
EFNA5	Physical association	Medium	0.56	28
FAM161A	Physical association	Medium	0.56	118
FAM50B	Physical association	Medium	0.56	39
FAM90A1	Physical association	Medium	0.56	128
FIS1	Physical association	Medium	0.56	22
FTCD	Physical association	Medium	0.56	5
GABARAPL2	Physical association	Medium	0.56	74
GIMAP5	Physical association	Medium	0.56	53
ITGAM	Physical association	Medium	0.56	34
ITM2B	Physical association	Medium	0.56	8
LARP1	Physical association	Medium	0.56	5
LENG1	Physical association	Medium	0.56	63
LRCH4	Physical association	Medium	0.56	14
MALL	Physical association	Medium	0.56	51
MARCHF2	Physical association	Medium	0.56	23
MFSD5	Physical association	Medium	0.56	46
MMP14	Physical association	Medium	0.56	17
MOSPD3	Physical association	Medium	0.56	13
MS4A1	Physical association	Medium	0.56	27
OLFM4	Physical association	Medium	0.56	24
PDGFRA	Physical association	Medium	0.56	5
PGRMC1	Physical association	Medium	0.56	15
PIGU	Physical association	Medium	0.56	2
PLP2	Physical association	Medium	0.56	58
PLPP6	Physical association	Medium	0.56	44
RNF146	Physical association	Medium	0.56	5
RSPH14	Physical association	Medium	0.56	36
RTP2	Physical association	Medium	0.56	63
SLC35B4	Physical association	Medium	0.56	25
SLC41A1	Physical association	Medium	0.56	26
SLC5A4	Physical association	Medium	0.56	3
SLN	Physical association	Medium	0.56	3
SMCO4	Physical association	Medium	0.56	51
SNAP47	Physical association	Medium	0.56	21
STBD1	Physical association	Medium	0.56	5
STX12	Physical association	Medium	0.56	33
TCF25	Physical association	Medium	0.56	9
TMEM147	Physical association	Medium	0.56	44
TMEM14C	Physical association	Medium	0.56	35
TMEM19	Physical association	Medium	0.56	34
TMEM199	Physical association	Medium	0.56	15
TMEM41A	Physical association	Medium	0.56	7
TMEM86A	Physical association	Medium	0.56	38
TMPRSS4	Physical association	Medium	0.56	10
TNF	Physical association	Medium	0.56	32
TSHZ3	Physical association	Medium	0.56	24
UPK1B	Physical association	Medium	0.56	41
UPK2	Physical association	Medium	0.56	20
VAMP1	Physical association	Medium	0.56	3
VAMP2	Physical association	Medium	0.56	25
VAMP4	Physical association	Medium	0.56	35
VTI1B	Physical association	Medium	0.56	26
ZFPL1	Physical association	Medium	0.56	54
NTAQ1	Physical association	Medium	0.49	302
SHMT2	Physical association	Medium	0.49	10
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
KASH5 is not a metabolic protein