Protein interactions for SGTA - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SGTA
Gene descriptionⁱ Full gene name according to HGNC.	Small glutamine rich tetratricopeptide repeat co-chaperone alpha
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Mitochondrial translation (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.22
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nucleoplasm
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Mitochondrial translation

Field

Cluster

Pathway

Number of interactions:

136

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
EFEMP1	Physical association	High	0.93	27
SGCA	Physical association	High	0.9	6
F11R	Physical association	High	0.83	18
SPP1	Physical association	High	0.83	7
COL1A2	Physical association	High	0.81	9
BAG6	Physical association	High	0.8	11
KASH5	Physical association	High	0.79	96
ADIPOQ	Physical association	High	0.78	46
EFEMP2	Physical association	High	0.78	83
ERP27	Physical association	High	0.78	10
GRN	Physical association	High	0.78	216
NAXD	Physical association	High	0.78	13
NME3	Physical association	High	0.78	7
RPN1	Physical association	High	0.78	7
SPPL2A	Physical association	High	0.78	2
SRGN	Physical association	High	0.78	8
SYT11	Physical association	High	0.78	4
SYT4	Physical association	High	0.78	4
ZG16	Physical association	High	0.78	7
FXYD7	Physical association	High	0.75	2
UBL4A	Physical association	High	0.75	12
AGR3	Physical association	High	0.72	21
BTC	Physical association	High	0.72	7
C1QTNF6	Physical association	High	0.72	2
C3orf52	Physical association	High	0.72	57
CD79B	Physical association	High	0.72	2
CD99L2	Physical association	High	0.72	7
CDH15	Physical association	High	0.72	3
CSF1	Physical association	High	0.72	7
EVA1B	Physical association	High	0.72	6
FKBP7	Physical association	High	0.72	59
GAL	Physical association	High	0.72	6
GIP	Physical association	High	0.72	4
HSPA13	Physical association	High	0.72	6
LAIR2	Physical association	High	0.72	5
MYDGF	Physical association	High	0.72	12
PPIB	Physical association	High	0.72	17
PPIC	Physical association	High	0.72	8
PRAP1	Physical association	High	0.72	7
SDC4	Physical association	High	0.72	5
SERPINE1	Physical association	High	0.72	8
SLPI	Physical association	High	0.72	12
TFRC	Physical association	High	0.72	23
TMEM174	Physical association	High	0.72	12
GPX7	Physical association	High	0.7	10
C1QTNF1	Physical association	High	0.67	3
PBXIP1	Physical association	High	0.67	13
PLAAT4	Physical association	High	0.67	2
SMIM5	Physical association	High	0.6	7
ADAM21	Physical association	Medium	0.56	2
AGR2	Physical association	Medium	0.56	62
AOC3	Physical association	Medium	0.56	10
C1QL4	Physical association	Medium	0.56	16
C1QTNF5	Physical association	Medium	0.56	5
C5orf46	Physical association	Medium	0.56	11
CREB3L3	Physical association	Medium	0.56	18
CST1	Physical association	Medium	0.56	4
CTAG1A	Physical association	Medium	0.56	57
CTAG1B	Physical association	Medium	0.56	57
CTSL	Physical association	Medium	0.56	1
CYB5R1	Physical association	Medium	0.56	6
DEFB131A	Physical association	Medium	0.56	1
DKK3	Physical association	Medium	0.56	2
DMKN	Physical association	Medium	0.56	6
EDA2R	Physical association	Medium	0.56	10
ERP29	Physical association	Medium	0.56	16
ETNK1	Physical association	Medium	0.56	6
FERD3L	Physical association	Medium	0.56	4
FGF21	Physical association	Medium	0.56	6
FSTL1	Physical association	Medium	0.56	8
FZD7	Physical association	Medium	0.56	18
GALP	Physical association	Medium	0.56	2
GUCA2A	Physical association	Medium	0.56	9
GYPA	Physical association	Medium	0.56	24
IER3	Physical association	Medium	0.56	11
IGFBP6	Physical association	Medium	0.56	28
IL6ST	Physical association	Medium	0.56	8
ITPRIPL1	Physical association	Medium	0.56	2
KCNA1	Physical association	Medium	0.56	13
KCNA10	Physical association	Medium	0.56	5
KCNE5	Physical association	Medium	0.56	4
KRT6A	Physical association	Medium	0.56	30
KTN1	Physical association	Medium	0.56	6
LAT	Physical association	Medium	0.56	6
LCN2	Physical association	Medium	0.56	47
LSMEM2	Physical association	Medium	0.56	18
MRAP2	Physical association	Medium	0.56	6
MS4A3	Physical association	Medium	0.56	34
MSMB	Physical association	Medium	0.56	1
MYOC	Physical association	Medium	0.56	4
NPVF	Physical association	Medium	0.56	2
NRSN2	Physical association	Medium	0.56	1
PAGE3	Physical association	Medium	0.56	4
PCDHA4	Physical association	Medium	0.56	1
PCDHGA4	Physical association	Medium	0.56	3
PSORS1C2	Physical association	Medium	0.56	18
RCN1	Physical association	Medium	0.56	19
RNASE10	Physical association	Medium	0.56	6
RNF144A	Physical association	Medium	0.56	10
SDF2L1	Physical association	Medium	0.56	3
SERPINI2	Physical association	Medium	0.56	5
SGTB	Physical association	Medium	0.56	96
SHISA4	Physical association	Medium	0.56	8
SMAGP	Physical association	Medium	0.56	35
SMIM14	Physical association	Medium	0.56	5
SOD3	Physical association	Medium	0.56	5
SPINK9	Physical association	Medium	0.56	1
SPN	Physical association	Medium	0.56	6
STMP1	Physical association	Medium	0.56	1
SUOX	Physical association	Medium	0.56	67
TFF3	Physical association	Medium	0.56	3
TGFA	Physical association	Medium	0.56	3
TMEM154	Physical association	Medium	0.56	9
TMEM31	Physical association	Medium	0.56	2
TMEM98	Physical association	Medium	0.56	6
TMPRSS11D	Physical association	Medium	0.56	1
TMUB2	Physical association	Medium	0.56	15
TNFRSF10C	Physical association	Medium	0.56	23
TNFRSF13B	Physical association	Medium	0.56	3
TNFRSF21	Physical association	Medium	0.56	2
TNFSF12	Physical association	Medium	0.56	6
TWSG1	Physical association	Medium	0.56	7
TXNDC12	Physical association	Medium	0.56	8
UBQLN2	Physical association	Medium	0.56	212
UPK3A	Physical association	Medium	0.56	2
VIP	Physical association	Medium	0.56	1
WBP1L	Physical association	Medium	0.56	15
WFDC12	Physical association	Medium	0.56	5
WFDC13	Physical association	Medium	0.56	1
WFDC5	Physical association	Medium	0.56	4
ZBTB8B	Physical association	Medium	0.56	6
ZG16B	Physical association	Medium	0.56	6
PTN	Physical association	Medium	0.55	10
IRF3	Physical association	Medium	0.54	12
IRF5	Physical association	Medium	0.54	4
BAG2	Physical association	Medium	0.5	12
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
SGTA is not a metabolic protein