Protein interactions for UBQLN2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	UBQLN2
Gene descriptionⁱ Full gene name according to HGNC.	Ubiquilin 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Brain - Synaptic signal transduction (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.21
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Cytosol In addition localized to the Plasma membrane
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Brain - Synaptic signal transduction

Field

Cluster

Pathway

Number of interactions:

212

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
RAD23A	Direct interaction	High	0.71	41
ADRM1	Direct interaction	High	0.71	9
C1QA	Physical association	High	0.67	3
HSPA13	Physical association	High	0.67	6
RNF11	Physical association	High	0.67	153
ADAMTS3	Physical association	Medium	0.56	1
AGR2	Physical association	Medium	0.56	62
AGR3	Physical association	Medium	0.56	21
AMBN	Physical association	Medium	0.56	5
APOC4	Physical association	Medium	0.56	22
ARRDC3	Physical association	Medium	0.56	36
ASCL1	Physical association	Medium	0.56	6
ASPA	Physical association	Medium	0.56	8
ATXN10	Physical association	Medium	0.56	35
AZGP1	Physical association	Medium	0.56	2
BCL2L11	Physical association	Medium	0.56	15
BPIFA1	Physical association	Medium	0.56	38
C1orf94	Physical association	Medium	0.56	69
C1QC	Physical association	Medium	0.56	3
C1QL4	Physical association	Medium	0.56	16
C1QTNF2	Physical association	Medium	0.56	17
C1QTNF4	Physical association	Medium	0.56	3
C6orf15	Physical association	Medium	0.56	5
C8G	Physical association	Medium	0.56	2
CAPN15	Physical association	Medium	0.56	6
CCK	Physical association	Medium	0.56	32
CCL16	Physical association	Medium	0.56	2
CCL3	Physical association	Medium	0.56	3
CCL7	Physical association	Medium	0.56	2
CCN1	Physical association	Medium	0.56	2
CD99L2	Physical association	Medium	0.56	7
CDH15	Physical association	Medium	0.56	3
CDH17	Physical association	Medium	0.56	1
CDIP1	Physical association	Medium	0.56	10
CEACAM6	Physical association	Medium	0.56	25
CLEC11A	Physical association	Medium	0.56	6
CLPSL2	Physical association	Medium	0.56	1
CNNM3	Physical association	Medium	0.56	59
COL10A1	Physical association	Medium	0.56	7
COL17A1	Physical association	Medium	0.56	6
COL1A2	Physical association	Medium	0.56	9
COL8A1	Physical association	Medium	0.56	51
COL9A2	Physical association	Medium	0.56	2
COLGALT2	Physical association	Medium	0.56	2
CSN1S1	Physical association	Medium	0.56	1
CSN2	Physical association	Medium	0.56	2
CSN3	Physical association	Medium	0.56	5
CST1	Physical association	Medium	0.56	4
CST4	Physical association	Medium	0.56	1
CSTF2	Physical association	Medium	0.56	23
CSTF2T	Physical association	Medium	0.56	14
CTAG1A	Physical association	Medium	0.56	57
CTAG1B	Physical association	Medium	0.56	57
CTDNEP1	Physical association	Medium	0.56	2
DAZAP2	Physical association	Medium	0.56	124
DEFA1	Physical association	Medium	0.56	1
DEFA1B	Physical association	Medium	0.56	1
DEFA6	Physical association	Medium	0.56	3
DEFB115	Physical association	Medium	0.56	2
DESI1	Physical association	Medium	0.56	21
DMKN	Physical association	Medium	0.56	6
DUSP21	Physical association	Medium	0.56	15
ECM1	Physical association	Medium	0.56	27
ECRG4	Physical association	Medium	0.56	2
EFEMP1	Physical association	Medium	0.56	27
EGFL6	Physical association	Medium	0.56	2
ERP27	Physical association	Medium	0.56	10
ERP29	Physical association	Medium	0.56	16
ETNK1	Physical association	Medium	0.56	6
F10	Physical association	Medium	0.56	3
FAM222B	Physical association	Medium	0.56	25
FDCSP	Physical association	Medium	0.56	1
FGF17	Physical association	Medium	0.56	1
FKBP2	Physical association	Medium	0.56	5
FNDC11	Physical association	Medium	0.56	37
FUCA1	Physical association	Medium	0.56	3
FZD7	Physical association	Medium	0.56	18
GAL	Physical association	Medium	0.56	6
GALP	Physical association	Medium	0.56	2
GHRL	Physical association	Medium	0.56	2
GPR162	Physical association	Medium	0.56	2
GPX7	Physical association	Medium	0.56	10
GUCA2A	Physical association	Medium	0.56	9
GUCA2B	Physical association	Medium	0.56	2
HEMK1	Physical association	Medium	0.56	18
HEXB	Physical association	Medium	0.56	25
HGS	Physical association	Medium	0.56	177
HSD17B12	Physical association	Medium	0.56	5
HTT	Physical association	Medium	0.56	665
ICAM1	Physical association	Medium	0.56	7
IFNA1	Physical association	Medium	0.56	1
IFNA13	Physical association	Medium	0.56	1
IGFBP6	Physical association	Medium	0.56	28
IGLL1	Physical association	Medium	0.56	2
IL11	Physical association	Medium	0.56	3
IQCF3	Physical association	Medium	0.56	1
ITPKB	Physical association	Medium	0.56	8
JPH4	Physical association	Medium	0.56	2
KISS1	Physical association	Medium	0.56	1
KLHL11	Physical association	Medium	0.56	3
KLHL42	Physical association	Medium	0.56	24
KRT6A	Physical association	Medium	0.56	30
KRTAP12-1	Physical association	Medium	0.56	50
KRTAP19-3	Physical association	Medium	0.56	11
KRTAP19-5	Physical association	Medium	0.56	82
LAIR2	Physical association	Medium	0.56	5
LCN1	Physical association	Medium	0.56	3
LCN2	Physical association	Medium	0.56	47
LITAF	Physical association	Medium	0.56	47
LMO4	Physical association	Medium	0.56	85
LY6G6D	Physical association	Medium	0.56	3
MAGED1	Physical association	Medium	0.56	79
MBL2	Physical association	Medium	0.56	9
MDK	Physical association	Medium	0.56	9
MIEF1	Physical association	Medium	0.56	19
MINPP1	Physical association	Medium	0.56	1
MOAP1	Physical association	Medium	0.56	7
MTX2	Physical association	Medium	0.56	4
MYDGF	Physical association	Medium	0.56	12
NAXD	Physical association	Medium	0.56	13
NDOR1	Physical association	Medium	0.56	21
NME3	Physical association	Medium	0.56	7
NOC4L	Physical association	Medium	0.56	11
NOL3	Physical association	Medium	0.56	5
NPBWR1	Physical association	Medium	0.56	1
NPPA	Physical association	Medium	0.56	4
NPVF	Physical association	Medium	0.56	2
NPY	Physical association	Medium	0.56	1
NRN1L	Physical association	Medium	0.56	1
NT5C3A	Physical association	Medium	0.56	2
NUP58	Physical association	Medium	0.56	77
ODAPH	Physical association	Medium	0.56	3
OPN4	Physical association	Medium	0.56	1
OR7D4	Physical association	Medium	0.56	2
OSMR	Physical association	Medium	0.56	9
PARM1	Physical association	Medium	0.56	1
PIANP	Physical association	Medium	0.56	4
PIK3IP1	Physical association	Medium	0.56	7
PIN1	Physical association	Medium	0.56	112
PLAAT2	Physical association	Medium	0.56	5
PLAAT3	Physical association	Medium	0.56	3
PLEKHB2	Physical association	Medium	0.56	37
PNMA3	Physical association	Medium	0.56	10
POLE2	Physical association	Medium	0.56	11
PPIB	Physical association	Medium	0.56	17
PPIC	Physical association	Medium	0.56	8
PPIH	Physical association	Medium	0.56	11
PRAP1	Physical association	Medium	0.56	7
PRR4	Physical association	Medium	0.56	5
PSMD2	Physical association	Medium	0.56	25
PSORS1C2	Physical association	Medium	0.56	18
PTGDS	Physical association	Medium	0.56	10
QPCT	Physical association	Medium	0.56	1
RAD23B	Physical association	Medium	0.56	15
RNF128	Physical association	Medium	0.56	4
RNF208	Physical association	Medium	0.56	20
RNF4	Physical association	Medium	0.56	80
RPS27A	Physical association	Medium	0.56	15
RSRC2	Physical association	Medium	0.56	5
RTL8A	Physical association	Medium	0.56	3
RTL8B	Physical association	Medium	0.56	7
RTL8C	Physical association	Medium	0.56	7
SCG5	Physical association	Medium	0.56	3
SCGB2B2	Physical association	Medium	0.56	1
SERPINE1	Physical association	Medium	0.56	8
SERPINI2	Physical association	Medium	0.56	5
SEZ6	Physical association	Medium	0.56	1
SFTPA2	Physical association	Medium	0.56	2
SGTA	Physical association	Medium	0.56	136
SLC16A3	Physical association	Medium	0.56	7
SLITRK1	Physical association	Medium	0.56	1
SLPI	Physical association	Medium	0.56	12
SMIM11	Physical association	Medium	0.56	2
SMIM19	Physical association	Medium	0.56	4
SMIM2	Physical association	Medium	0.56	2
SMR3B	Physical association	Medium	0.56	3
SOD3	Physical association	Medium	0.56	5
SPN	Physical association	Medium	0.56	6
SRGN	Physical association	Medium	0.56	8
STAM2	Physical association	Medium	0.56	31
SUOX	Physical association	Medium	0.56	67
TENT5B	Physical association	Medium	0.56	57
TFF3	Physical association	Medium	0.56	3
TIMM21	Physical association	Medium	0.56	2
TIMP2	Physical association	Medium	0.56	2
TMEM123	Physical association	Medium	0.56	6
TOMM20L	Physical association	Medium	0.56	4
TRAF4	Physical association	Medium	0.56	73
TRIM32	Physical association	Medium	0.56	30
TXNDC12	Physical association	Medium	0.56	8
TXNDC5	Physical association	Medium	0.56	2
UACA	Physical association	Medium	0.56	9
UBA52	Physical association	Medium	0.56	14
UBAC1	Physical association	Medium	0.56	24
UBB	Physical association	Medium	0.56	31
UBC	Physical association	Medium	0.56	56
UBE2V1	Physical association	Medium	0.56	23
UBQLN1	Physical association	Medium	0.56	213
UBXN7	Physical association	Medium	0.56	22
UFSP1	Physical association	Medium	0.56	30
VENTX	Physical association	Medium	0.56	60
VTN	Physical association	Medium	0.56	7
VWC2	Physical association	Medium	0.56	51
WFDC10B	Physical association	Medium	0.56	1
WFDC12	Physical association	Medium	0.56	5
ZFAND2A	Physical association	Medium	0.56	5
ZFAND2B	Physical association	Medium	0.56	2
ZG16	Physical association	Medium	0.56	7
ZG16B	Physical association	Medium	0.56	6
ZNF205	Physical association	Medium	0.56	6
HNRNPA1	Physical association	Medium	0.52	8
HNRNPU	Physical association	Medium	0.51	6
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
UBQLN2 is not a metabolic protein