Protein interactions for UBQLN1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	UBQLN1
Gene descriptionⁱ Full gene name according to HGNC.	Ubiquilin 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Basic cellular processes (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.20
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nucleoplasm In addition localized to the Cytosol
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Basic cellular processes

Field

Cluster

Pathway

Number of interactions:

213

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
SERPINI2	Physical association	High	0.9	5
HSPA13	Physical association	High	0.83	6
UBE2V1	Physical association	High	0.81	23
CSTF2	Physical association	High	0.78	23
CSTF2T	Physical association	High	0.78	14
NGLY1	Physical association	High	0.78	12
PLAAT3	Physical association	High	0.78	3
TRIM32	Physical association	High	0.78	30
ZG16	Physical association	High	0.78	7
RIC8A	Physical association	High	0.75	2
EFEMP2	Physical association	High	0.74	83
FZD7	Physical association	High	0.74	18
UBQLN4	Physical association	High	0.72	20
AGPAT5	Physical association	High	0.72	5
AGR2	Physical association	High	0.72	62
CD99L2	Physical association	High	0.72	7
COL10A1	Physical association	High	0.72	7
COL1A2	Physical association	High	0.72	9
CTAG1A	Physical association	High	0.72	57
CTAG1B	Physical association	High	0.72	57
GYPB	Physical association	High	0.72	4
HSD17B12	Physical association	High	0.72	5
NME3	Physical association	High	0.72	7
PRAP1	Physical association	High	0.72	7
RTL8B	Physical association	High	0.72	7
RTL8C	Physical association	High	0.72	7
SRGN	Physical association	High	0.72	8
TRIM23	Physical association	High	0.72	142
UBXN4	Physical association	High	0.72	4
AGR3	Physical association	High	0.67	21
DEFA6	Physical association	High	0.67	3
ERP27	Physical association	High	0.67	10
GABRD	Physical association	High	0.67	3
HK2	Physical association	High	0.67	3
KLHL42	Physical association	High	0.67	24
MIEF2	Physical association	High	0.67	4
PNMA1	Physical association	High	0.67	114
RPN1	Physical association	High	0.67	7
RTL8A	Physical association	High	0.67	3
SCG2	Physical association	High	0.67	2
TFF1	Physical association	High	0.67	9
TMCO6	Physical association	High	0.67	2
TXNDC12	Physical association	High	0.67	8
PSMD4	Direct interaction	High	0.61	24
ADRM1	Direct interaction	Medium	0.59	9
PSEN1	Direct interaction	Medium	0.56	18
PSEN2	Direct interaction	Medium	0.56	41
ACOT7	Physical association	Medium	0.56	8
ANOS1	Physical association	Medium	0.56	3
APOC4	Physical association	Medium	0.56	22
APP	Physical association	Medium	0.56	312
ASCL1	Physical association	Medium	0.56	6
ASCL4	Physical association	Medium	0.56	34
ATXN3	Physical association	Medium	0.56	74
BAHD1	Physical association	Medium	0.56	54
BLZF1	Physical association	Medium	0.56	84
BPIFA1	Physical association	Medium	0.56	38
C1QTNF4	Physical association	Medium	0.56	3
CCL3	Physical association	Medium	0.56	3
CCL7	Physical association	Medium	0.56	2
CDIP1	Physical association	Medium	0.56	10
CDKN1A	Physical association	Medium	0.56	49
CDS2	Physical association	Medium	0.56	29
CHMP7	Physical association	Medium	0.56	15
COL9A2	Physical association	Medium	0.56	2
CSN3	Physical association	Medium	0.56	5
CXorf38	Physical association	Medium	0.56	10
CYB5R1	Physical association	Medium	0.56	6
DAZAP2	Physical association	Medium	0.56	124
DBNL	Physical association	Medium	0.56	10
DEFB115	Physical association	Medium	0.56	2
DESI1	Physical association	Medium	0.56	21
DEXI	Physical association	Medium	0.56	8
DLX3	Physical association	Medium	0.56	7
DMKN	Physical association	Medium	0.56	6
DNTTIP1	Physical association	Medium	0.56	11
DPPA2	Physical association	Medium	0.56	4
DPYS	Physical association	Medium	0.56	9
DPYSL5	Physical association	Medium	0.56	16
DSCC1	Physical association	Medium	0.56	2
DUSP10	Physical association	Medium	0.56	10
E2F8	Physical association	Medium	0.56	16
ECM1	Physical association	Medium	0.56	27
ELL2	Physical association	Medium	0.56	16
ERP29	Physical association	Medium	0.56	16
ESRP1	Physical association	Medium	0.56	28
ETNK1	Physical association	Medium	0.56	6
FAM163A	Physical association	Medium	0.56	17
FAM163B	Physical association	Medium	0.56	2
FAM184A	Physical association	Medium	0.56	5
FAM83A	Physical association	Medium	0.56	22
FCGR2A	Physical association	Medium	0.56	1
FKBP2	Physical association	Medium	0.56	5
FN1	Physical association	Medium	0.56	21
FOLR3	Physical association	Medium	0.56	1
FOSL2	Physical association	Medium	0.56	20
GAL	Physical association	Medium	0.56	6
GHRL	Physical association	Medium	0.56	2
GPR162	Physical association	Medium	0.56	2
GUCA2A	Physical association	Medium	0.56	9
GUCA2B	Physical association	Medium	0.56	2
HID1	Physical association	Medium	0.56	9
IER3IP1	Physical association	Medium	0.56	34
IGFBP6	Physical association	Medium	0.56	28
IL37	Physical association	Medium	0.56	6
IST1	Physical association	Medium	0.56	4
ITPRIPL1	Physical association	Medium	0.56	2
JPH4	Physical association	Medium	0.56	2
JSRP1	Physical association	Medium	0.56	7
JUN	Physical association	Medium	0.56	48
KCTD17	Physical association	Medium	0.56	29
KRTAP8-1	Physical association	Medium	0.56	76
LAIR2	Physical association	Medium	0.56	5
LAMB1	Physical association	Medium	0.56	3
LAMTOR1	Physical association	Medium	0.56	15
LAMTOR5	Physical association	Medium	0.56	17
LCN2	Physical association	Medium	0.56	47
LHX5	Physical association	Medium	0.56	17
LHX8	Physical association	Medium	0.56	28
LITAF	Physical association	Medium	0.56	47
MAOB	Physical association	Medium	0.56	14
MDK	Physical association	Medium	0.56	9
MESD	Physical association	Medium	0.56	51
MRPS14	Physical association	Medium	0.56	3
MYC	Physical association	Medium	0.56	88
MYDGF	Physical association	Medium	0.56	12
NAXD	Physical association	Medium	0.56	13
NBL1	Physical association	Medium	0.56	2
NDEL1	Physical association	Medium	0.56	60
NDOR1	Physical association	Medium	0.56	21
NPPA	Physical association	Medium	0.56	4
NR1D2	Physical association	Medium	0.56	10
NXF1	Physical association	Medium	0.56	62
ODAD3	Physical association	Medium	0.56	16
OST4	Physical association	Medium	0.56	2
PALS1	Physical association	Medium	0.56	19
PCDH18	Physical association	Medium	0.56	1
PDE6H	Physical association	Medium	0.56	5
PER1	Physical association	Medium	0.56	21
PIK3IP1	Physical association	Medium	0.56	7
PKM	Physical association	Medium	0.56	11
PLAAT1	Physical association	Medium	0.56	7
PLAAT2	Physical association	Medium	0.56	5
PLEKHG7	Physical association	Medium	0.56	18
PNKP	Physical association	Medium	0.56	34
POLR1D	Physical association	Medium	0.56	6
POLR2E	Physical association	Medium	0.56	39
PPIB	Physical association	Medium	0.56	17
PPIC	Physical association	Medium	0.56	8
PPP1R11	Physical association	Medium	0.56	9
PPP1R16A	Physical association	Medium	0.56	35
PRKAB2	Physical association	Medium	0.56	126
PRR4	Physical association	Medium	0.56	5
PSMD6	Physical association	Medium	0.56	17
PSME1	Physical association	Medium	0.56	7
PSORS1C2	Physical association	Medium	0.56	18
RAI2	Physical association	Medium	0.56	13
RELA	Physical association	Medium	0.56	54
RHEB	Physical association	Medium	0.56	10
RNF208	Physical association	Medium	0.56	20
RNF4	Physical association	Medium	0.56	80
RPL31	Physical association	Medium	0.56	5
RPS27A	Physical association	Medium	0.56	15
SCG5	Physical association	Medium	0.56	3
SCMH1	Physical association	Medium	0.56	6
SERPINE1	Physical association	Medium	0.56	8
SIL1	Physical association	Medium	0.56	3
SLC16A3	Physical association	Medium	0.56	7
SLPI	Physical association	Medium	0.56	12
SMIM19	Physical association	Medium	0.56	4
SMIM2	Physical association	Medium	0.56	2
SMR3B	Physical association	Medium	0.56	3
SNW1	Physical association	Medium	0.56	89
SOCS6	Physical association	Medium	0.56	13
SOD3	Physical association	Medium	0.56	5
SPATA12	Physical association	Medium	0.56	22
SPATS1	Physical association	Medium	0.56	17
SPRY4	Physical association	Medium	0.56	30
STAC	Physical association	Medium	0.56	15
STAM2	Physical association	Medium	0.56	31
STIM1	Physical association	Medium	0.56	20
TBX6	Physical association	Medium	0.56	24
TCAP	Physical association	Medium	0.56	34
TEN1	Physical association	Medium	0.56	14
TEX12	Physical association	Medium	0.56	28
THAP3	Physical association	Medium	0.56	15
TIMM17B	Physical association	Medium	0.56	18
TMEM186	Physical association	Medium	0.56	4
TMEM258	Physical association	Medium	0.56	4
TMEM31	Physical association	Medium	0.56	2
TMEM61	Physical association	Medium	0.56	11
TSC22D4	Physical association	Medium	0.56	30
TSPAN2	Physical association	Medium	0.56	34
TTC23L	Physical association	Medium	0.56	19
UBA52	Physical association	Medium	0.56	14
UBE2A	Physical association	Medium	0.56	17
UBQLN2	Physical association	Medium	0.56	212
UBXN1	Physical association	Medium	0.56	3
UBXN7	Physical association	Medium	0.56	22
USF1	Physical association	Medium	0.56	13
VWC2	Physical association	Medium	0.56	51
WBP1L	Physical association	Medium	0.56	15
WFDC12	Physical association	Medium	0.56	5
WNT7A	Physical association	Medium	0.56	5
ZBTB14	Physical association	Medium	0.56	54
ZBTB8B	Physical association	Medium	0.56	6
ZCCHC17	Physical association	Medium	0.56	13
ZMYM4	Physical association	Medium	0.56	3
ZNF296	Physical association	Medium	0.56	9
ZNF343	Physical association	Medium	0.56	18
EPS15	Physical association	Medium	0.56	9
EP300	Physical association	Medium	0.49	34
DNAJB2	Physical association	Medium	0.46	1
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
UBQLN1 is not a metabolic protein